Search Results - "Seo, Kang‐Sik"

Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson's Disease by Lee, Joo-Eun, Sim, Hyuna, Yoo, Hee Min, Lee, Minhyung, Baek, Aruem, Jeon, Young-Joo, Seo, Kang-Sik, Son, Mi-Young, Yoon, Joo Seog, Kim, Janghwan

“…Parkinson's disease (PD) is a well-known age-related neurodegenerative disease. Considering the vital importance of disease modeling based on reprogramming…”
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Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53 by Jing, Kaipeng, Song, Kyoung-Sub, Shin, Soyeon, Kim, Nayeong, Jeong, Soyeon, Oh, Hye-Rim, Park, Ji-Hoon, Seo, Kang-Sik, Heo, Jun-Young, Han, Jeongsu, Park, Jong-Il, Han, Chang, Wu, Tong, Kweon, Gi-Ryang, Park, Seung-Kiel, Yoon, Wan-Hee, Hwang, Byung-Doo, Lim, Kyu

“…Docosahexaenoic acid (DHA) has been reported to induce tumor cell death by apoptosis. However, little is known about the effects of DHA on autophagy, another…”
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The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53 by Han, Jeongsu, Kweon, Gi-Ryang, Park, Seung-Kiel, Wu, Tong, Hwang, Byung-Doo, Lim, Kyu, Seo, Kang-Sik, Park, Ji-Hoon, Heo, Jun-Young, Song, Kyoung-Sub, Kim, Nayeong, Jeong, Soyeon, Jing, Kaipeng, Shin, Soyeon, Park, Jong-Il

“…Docosahexaenoic acid (DHA) induces autophagy-associated apoptotic cell death in wild-type p53 cancer cells via regulation of p53. The present study…”
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Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells by Jeong, Soyeon, Jing, Kaipeng, Kim, Nayeong, Shin, Soyeon, Kim, Soyeon, Song, Kyoung-Sub, Heo, Jun-Young, Park, Ji-Hoon, Seo, Kang-Sik, Han, Jeongsu, Wu, Tong, Kweon, Gi-Ryang, Park, Seung-Kiel, Park, Jong-Il, Lim, Kyu

“…The role of omega-3 polyunsaturated fatty acids (ω3-PUFAs) in cancer prevention has been demonstrated; however, the exact molecular mechanisms underlying the…”
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Downregulation of APE1/Ref‐1 Is Involved in the Senescence of Mesenchymal Stem Cells by Heo, Jun‐Young, Jing, Kaipeng, Song, Kyoung‐Sub, Seo, Kang‐Sik, Park, Ji‐Hoon, Kim, Jong‐Seok, Jung, Yeon‐Joo, Hur, Gang‐Min, Jo, Deog‐Yeon, Kweon, Gi‐Ryang, Yoon, Wan‐Hee, Lim, Kyu, Hwang, Byung‐Doo, Jeon, Byeong Hwa, Park, Jong‐Il

“…The senescence of human mesenchymal stem cells (hMSCs) causes disruption of tissue and organ maintenance, and is thus an obstacle to stem cell‐based therapies…”
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Omega-3-Polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in vitro and in vivo via Downregulation of Wnt/Beta-Catenin Signaling by Song, Kyoung-Sub, Jing, Kaipeng, Kim, Jong-Seok, Yun, Eun-Jin, Shin, Soyeon, Seo, Kang-Sik, Park, Ji-Hoon, Heo, Jun-Young, Kang, Jing X, Suh, Kwang-Sun, Wu, Tong, Park, Jong-Il, Kweon, Gi-Ryang, Yoon, Wan-Hee, Hwang, Byung-Doo, Lim, Kyu

“…Abstract Background/Aims: ω3-polyunsaturated fatty acids (ω3-PUFAs) are known to possess anticancer properties. However, the relationship between ω3-PUFAs and…”
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Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: The protective role of autophagy in apoptosis by Song, Kyoung-Sub, Kim, Jong-Seok, Yun, Eun-Jin, Kim, Young-Rae, Seo, Kang-Sik, Park, Ji-Hoon, Jung, Yeon-Joo, Park, Jong-Il, Kweon, Gi-Ryang, Yoon, Wan-Hee, Lim, Kyu, Hwang, Byung-Doo

“…Rottlerin is widely used as a protein kinase C-δ inhibitor. Recently, several reports have shown the possible apoptosis-inducing effect of rottlerin in some…”
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KL1333, a Novel NAD + Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts by Seo, Kang-Sik, Kim, Jin-Hwan, Min, Ki-Nam, Moon, Jeong-A, Roh, Tae-Chul, Lee, Mi-Jung, Lee, Kang-Woo, Min, Ji-Eun, Lee, Young-Mock

“…Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), one of the most common maternally inherited mitochondrial diseases, is…”
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Beta-lapachone ameliorates the progression of primary sclerosing cholangitis pathogenesis in rodent models by Woo, Seung Hee, Lee, Sang-Hee, Moon, Sung-Je, Han, Jeongsu, Seo, Kang-Sik, Lee, Heedoo, Lee, Chul-Ho, Hwang, Jung Hwan

“…Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by chronic inflammation and severe fibrosis for which effective…”
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DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly by Heo, Jun Young, Park, Ji Hoon, Kim, Soung Jung, Seo, Kang Sik, Han, Jeong Su, Lee, Sang Hee, Kim, Jin Man, Park, Jong Il, Park, Seung Kiel, Lim, Kyu, Hwang, Byung Doo, Shong, Minho, Kweon, Gi Ryang

“…DJ-1 is a Parkinson's disease-associated gene whose protein product has a protective role in cellular homeostasis by removing cytosolic reactive oxygen species…”
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Docosahexaenoic acid prevents paraquat-induced reactive oxygen species production in dopaminergic neurons via enhancement of glutathione homeostasis by Lee, Hyoung Jun, Han, Jeongsu, Jang, Yunseon, Kim, Soo Jeong, Park, Ji Hoon, Seo, Kang Sik, Jeong, Soyeon, Shin, Soyeon, Lim, Kyu, Heo, Jun Young, Kweon, Gi Ryang

“…•DHA prevents PQ-induced dopaminergic neuronal loss via decreasing of excessive ROS.•DHA increases GR and GCLm derivate GSH pool by enhancement of Nrf2…”
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β-Lapachone attenuates mitochondrial dysfunction in MELAS cybrid cells by Jeong, Moon Hee, Kim, Jin Hwan, Seo, Kang-sik, Kwak, Tae Hwan, Park, Woo Jin

“…•β-Lapachone (β-lap) restored mitochondrial dysfunctions in MELAS cybrid cells.•β-Lap ameliorated the defective energy production and lactic acidosis in MELAS…”
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An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice by Park, Ji-Hoon, Seo, Kang-Sik, Tadi, Surendar, Ahn, Bong-Hyun, Lee, Jung-Uee, Heo, Jun-Young, Han, Jeongsu, Song, Myoung-Sub, Kim, Soon-Ha, Yim, Yong-Hyeon, Choi, Hueng-Sik, Shong, Minho, Kweon, GiRyang

“…Acetaminophen (APAP)-induced liver injury is mainly due to the excessive formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) through…”
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DJ-1 mediates paraquat-induced dopaminergic neuronal cell death by Kwon, Hyun Joo, Heo, Jun Young, Shim, Jung Hee, Park, Ji Hoon, Seo, Kang Sik, Ryu, Min Jeong, Han, Jeong Su, Shong, Minho, Son, Jin H., Kweon, Gi Ryang

“…There are two causes of Parkinson's disease (PD): environmental insults and genetic mutations of PD-associated genes. Environmental insults and genetic…”
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Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells by Seo, Kang-Sik, Kim, Hoon, Hong, Tae-Hwa, Kim, Jong-Seok, Song, Kyoung-Sub, Yun, Eun-Jin, Park, Ji-Hoon, Jung, Young-Hoon, Park, Jong-Il, Kweon, Gi Ryang, Yoon, Wan-Hee, Lim, Kyu, Hwang, Byung-Doo

“…•We synthesized the acetyl derivative of the antitumor agent apicularen A.•Apicularen A acetate induces cytotoxicity and sub-G1 accumulation in HM7…”
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PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells by Seo, Kang-Sik, Kim, Jong-Seok, Park, Ji-Hoon, Song, Kyoung-Sub, Yun, Eun-Jin, Park, Jong-Il, Kweon, Gi Ryang, Yoon, Wan-Hee, Lim, Kyu, Hwang, Byung-Doo

“…Combination therapy is key to improving cancer treatment efficacy. Phorbol 12-myristate 13-acetate (PMA), a well-known PKC activator, increases the…”
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Expression regulation and function of Pref-1 during adipogenesis of human mesenchymal stem cells (MSCs) by Jing, Kaipeng, Heo, Jun-Young, Song, Kyoung-Sub, Seo, Kang-Sik, Park, Ji-Hoon, Kim, Jong-Seok, Jung, Yeon-Joo, Jo, Deog-Yeon, Kweon, Gi-Ryang, Yoon, Wan-Hee, Hwang, Byung-Doo, Lim, Kyu, Park, Jong-Il

“…Preadipocyte Factor 1 (Pref-1), also known as Delta-like Protein 1 (DLK-1) is an epidermal growth factor-like domain-containing trans-membrane protein that is…”
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Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells by Kim, Jong-Seok, Lee, Young-Chul, Nam, Ho-Tak, Li, Ge, Yun, Eun-Jin, Song, Kyoung-Sub, Seo, Kang-Sik, Park, Ji-Hoon, Ahn, Jong-Woong, Zee, Okpyo, Park, Jong-Il, Yoon, Wan-Hee, Lim, Kyu, Hwang, Byung-Doo

“…Purpose: Apicularen A has been shown to cause growth inhibition and apoptosis in several cancer cell lines. However, the mechanisms of apicularen A–induced…”
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Salvia miltiorrhiza Bunge Ameliorates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress via Nrf-2/HO-1 Activation by Choi, Young-Jin, Wedamulla, Nishala Erandi, Kim, Seok-Hee, Oh, Mirae, Seo, Kang Sik, Han, Jeong Su, Lee, Eun Joo, Park, Young Ho, Park, Young Jin, Kim, Eun-Kyung

“…Oxidative stress is a key factor in the pathogenesis of benign prostatic hyperplasia (BPH) that leads to inflammation. This study aimed to evaluate the…”
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Abstract 2697: YPN005, an oral CDK7 inhibitor, exhibits a significant antitumor activity in Myc-driven cancers by Lee, Kwang-Ok, Yoo, Jakyung, Lee, Mi Jung, Lee, Kang Woo, Min, Ji Eun, Kim, Jinhwan, Min, Ki-Nam, Roh, Tae Chul, Seo, Kang-Sik, Rhee, Hae In, Lee, Jun Hee, Jeon, Da-Hye, Lim, Dae Seong

“…Background: CDK7 plays an important role in regulating cell cycle progression and gene via activation of cell cycle kinases (CDK1, CDK2, CDK4 and CDK6) and RNA…”
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