Search Results - "Senyo, Samuel E."

Mammalian heart renewal by pre-existing cardiomyocytes by Senyo, Samuel E., Steinhauser, Matthew L., Pizzimenti, Christie L., Yang, Vicky K., Cai, Lei, Wang, Mei, Wu, Ting-Di, Guerquin-Kern, Jean-Luc, Lechene, Claude P., Lee, Richard T.

“…During normal ageing a low rate of division of pre-existing cardiomyocytes, rather than progenitor cells, is responsible for cardiomyocyte genesis; this…”
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Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance by Kim, Soo M., Lun, Mingyue, Wang, Mei, Senyo, Samuel E., Guillermier, Christelle, Patwari, Parth, Steinhauser, Matthew L.

“…Fat mass expansion occurs by adipocyte hypertrophy or recruitment of differentiating adipocyte progenitors, the relative balance of which may impact systemic…”
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Exercise induces new cardiomyocyte generation in the adult mammalian heart by Vujic, Ana, Lerchenmüller, Carolin, Wu, Ting-Di, Guillermier, Christelle, Rabolli, Charles P., Gonzalez, Emilia, Senyo, Samuel E., Liu, Xiaojun, Guerquin-Kern, Jean-Luc, Steinhauser, Matthew L., Lee, Richard T., Rosenzweig, Anthony

“…Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what…”
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Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism by Steinhauser, Matthew L., Bailey, Andrew P., Senyo, Samuel E., Guillermier, Christelle, Perlstein, Todd S., Gould, Alex P., Lee, Richard T., Lechene, Claude P.

“…Multi-isotope imaging mass spectrometry is used to investigate the ‘immortal strand hypothesis’, Drosophila lipid metabolism and human lymphopoiesis…”
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Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation by Senyo, Samuel E., Lee, Richard T., Kühn, Bernhard

“…Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of myocardial development. Cardiomyocytes continue to proliferate in…”
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mRNA therapy for myocardial infarction: A review of targets and delivery vehicles by Wang, Xinming, Wu, Douglas H, Senyo, Samuel E

“…Cardiovascular diseases are the leading cause of death in the world. This is partly due to the low regenerative capacity of adult hearts. mRNA therapy is a…”
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Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein by Boateng, Samuel Y, Senyo, Samuel E, Qi, Lixin, Goldspink, Paul H, Russell, Brenda

“…Abstract CSRP3 or muscle LIM protein (MLP) is a nucleocytoplasmic shuttling protein and a mechanosensor in cardiac myocytes. MLP regulation and function was…”
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Microenvironment Stiffness Amplifies Post-ischemia Heart Regeneration in Response to Exogenous Extracellular Matrix Proteins in Neonatal Mice by Wang, Xinming, Pierre, Valinteshley, Senapati, Subhadip, Park, Paul S-H, Senyo, Samuel E

“…The cardiogenesis of the fetal heart is absent in juveniles and adults. Cross-transplantation of decellularized extracellular matrix (dECM) can stimulate…”
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Scratching beneath the surface: IL4Rα blockade and the progression from myocardial ischemic injury to heart failure by Wu, Douglas H, Senyo, Samuel E

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Price check on A(i)s(l)e 13: investigation of interleukin-13 activity in cardiac regeneration by Senyo, Samuel E

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Microenvironment stiffness requires decellularized cardiac extracellular matrix to promote heart regeneration in the neonatal mouse heart by Wang, Xinming, Senapati, Subhadip, Akinbote, Akinola, Gnanasambandam, Bhargavee, Park, Paul S.-H., Senyo, Samuel E.

“…The transient period of regeneration potential in the postnatal heart suggests molecular changes with maturation influence the cardiac response to damage. We…”
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Lamellipodia-Mediated Osteoblast Haptotaxis Guided by Fibronectin Ligand Concentrations on a Multiplex Chip by Liu, Chao, Feng, Xiaotian, Jeong, Seoyoung, Carr, Melissa L, Gao, Yiwen, Atit, Radhika P, Senyo, Samuel E

“…Skull morphogenesis is a complex, dynamic process involving two different germ layers and progressing to the coordinated, directional growth of individual…”
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Multiplexed microfluidic chip for cell co-culture by Watson, Craig, Liu, Chao, Ansari, Ali, Miranda, Helen C, Somoza, Rodrigo A, Senyo, Samuel E

“…Paracrine signaling is challenging to study , as conventional culture tools dilute soluble factors and offer little to no spatiotemporal control over…”
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Cardiac fibroblasts: answering the call by Kleinbongard, Petra, Senyo, Samuel E, Lindsey, Merry L, Garvin, Alexandra M, Simpson, Jeremy A, de Castro Braz, Lisandra E

“…Cardiac fibroblasts play a pivotal role in maintaining heart homeostasis by depositing extracellular matrix (ECM) to provide structural support for the…”
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Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG by Wang, Xinming, Pierre, Valinteshley, Liu, Chao, Senapati, Subhadip, Park, Paul S.-H., Senyo, Samuel E.

“…Controlling fibrosis is an essential part of regenerating the post-ischemic heart. In the post-ischemic heart, fibroblasts differentiate to myofibroblasts that…”
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Ribonucleosides from tRNA in hyperglycemic mammalian cells and diabetic murine cardiac models by Dodson, Taylor A., Nieuwoudt, Stephan, Morse, Chase N., Pierre, Valinteshley, Liu, Chao, Senyo, Samuel E., Prestwich, Erin G.

“…Cardiomyopathy is a diabetic comorbidity with few molecular targets. To address this, we evaluated transfer RNA (tRNA) modifications in the diabetic heart…”
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Injectable Extracellular Matrix Microparticles Promote Heart Regeneration in Mice with Post‐ischemic Heart Injury by Wang, Xinming, Ansari, Ali, Pierre, Valinteshley, Young, Kathleen, Kothapalli, Chandrasekhar R., von Recum, Horst A., Senyo, Samuel E.

“…Ischemic heart injury causes permanent cardiomyocyte loss and fibrosis impairing cardiac function. Tissue derived biomaterials have shown promise as an…”
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Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies by Behmer Hansen, Ryan A., Wang, Xinming, Kaw, Gitanjali, Pierre, Valinteshley, Senyo, Samuel E.

“…Tissue decellularization has rapidly developed to be a practical approach in tissue engineering research; biological tissue is cleared of cells resulting in a…”
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Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes by Senyo, Samuel E., Koshman, Yevgeniya E., Russell, Brenda

“…The effect of interval, direction and rate of strain on mechanotransduction in neonatal rat cardiomyocytes is determined for focal adhesion kinase (Y397pFAK),…”
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Nucleocytoplasmic shuttling of muscle LIM protein is required for myocyte remodelling and adaptation to hypertrophic stimuli by Boateng, Samuel Y, Senyo, Samuel E, Lixin Qi, Russell, Brenda

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