Search Results - "Sensi, Stefano L."

Zinc in the physiology and pathology of the CNS by Sensi, Stefano L, Paoletti, Pierre, Bush, Ashley I, Sekler, Israel

“…Key Points The development of new imaging tools and transgenic animals has greatly improved our understanding of the physiological and pathophysiological role…”
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Intracellular zinc is a critical intermediate in the excitotoxic cascade by Granzotto, Alberto, Sensi, Stefano L

“…Abstract Excessive and sustained exposure to glutamate leads to injurious elevations of cytosolic calcium ([Ca 2 + ]i ), generation of reactive oxygen and…”
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The neurophysiology and pathology of brain zinc by Sensi, Stefano L, Paoletti, Pierre, Koh, Jae-Young, Aizenman, Elias, Bush, Ashley I, Hershfinkel, Michal

“…Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability…”
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Hallucinations, somatic‐functional disorders of PD‐DLB as expressions of thalamic dysfunction by Onofrj, Marco, Espay, Alberto J., Bonanni, Laura, Delli Pizzi, Stefano, Sensi, Stefano L.

“…Hallucinations, delusions, and functional neurological manifestations (conversion and somatic symptom disorders) of Parkinson's disease (PD) and dementia with…”
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NCLX is an essential component of mitochondrial Na⁺/Ca²⁺ exchange by Palty, Raz, Silverman, William F, Hershfinkel, Michal, Caporale, Teresa, Sensi, Stefano L, Parnis, Julia, Nolte, Christiane, Fishman, Daniel, Shoshan-Barmatz, Varda, Herrmann, Sharon, Khananshvili, Daniel, Sekler, Israel

“…Mitochondrial Ca²⁺ efflux is linked to numerous cellular activities and pathophysiological processes. Although it is established that an Na⁺-dependent…”
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The Role of Zinc in the Treatment of Wilson’s Disease by Avan, Abolfazl, Członkowska, Anna, Gaskin, Susan, Granzotto, Alberto, Sensi, Stefano L., Hoogenraad, Tjaard U.

“…Wilson’s disease (WD) is a hereditary disorder of copper metabolism, producing abnormally high levels of non-ceruloplasmin-bound copper, the determinant of the…”
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Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer's disease research by Granzotto, Alberto, Vissel, Bryce, Sensi, Stefano L

“…The recent, controversial approval of antibody-based treatments for Alzheimer's disease (AD) is fueling a heated debate on the molecular determinants of this…”
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A Neurotoxic Ménage-à-trois : Glutamate, Calcium, and Zinc in the Excitotoxic Cascade by Granzotto, Alberto, Canzoniero, Lorella M T, Sensi, Stefano L

“…Fifty years ago, the seminal work by John Olney provided the first evidence of the neurotoxic properties of the excitatory neurotransmitter glutamate. A…”
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Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice by Corona, Carlo, Frazzini, Valerio, Silvestri, Elena, Lattanzio, Rossano, La Sorda, Rossana, Piantelli, Mauro, Canzoniero, Lorella M T, Ciavardelli, Domenico, Rizzarelli, Enrico, Sensi, Stefano L

“…The pathogenic road map leading to Alzheimer's disease (AD) is still not completely understood; however, a large body of studies in the last few years supports…”
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TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia by Jairaman, Amit, McQuade, Amanda, Granzotto, Alberto, Kang, You Jung, Chadarevian, Jean Paul, Gandhi, Sunil, Parker, Ian, Smith, Ian, Cho, Hansang, Sensi, Stefano L, Othy, Shivashankar, Blurton-Jones, Mathew, Cahalan, Michael D

“…The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis…”
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Modafinil alters intrinsic functional connectivity of the right posterior insula: a pharmacological resting state fMRI study by Cera, Nicoletta, Tartaro, Armando, Sensi, Stefano L

“…Modafinil is employed for the treatment of narcolepsy and has also been, off-label, used to treat cognitive dysfunction in neuropsychiatric disorders. In a…”
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The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics by Onofrj, Marco, Russo, Mirella, Delli Pizzi, Stefano, De Gregorio, Danilo, Inserra, Antonio, Gobbi, Gabriella, Sensi, Stefano L.

“…The PD-DLB psychosis complex found in Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) includes hallucinations, Somatic Symptom/Functional…”
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Agitation and Dementia: Prevention and Treatment Strategies in Acute and Chronic Conditions by Carrarini, Claudia, Russo, Mirella, Dono, Fedele, Barbone, Filomena, Rispoli, Marianna G, Ferri, Laura, Di Pietro, Martina, Digiovanni, Anna, Ajdinaj, Paola, Speranza, Rino, Granzotto, Alberto, Frazzini, Valerio, Thomas, Astrid, Pilotto, Andrea, Padovani, Alessandro, Onofrj, Marco, Sensi, Stefano L, Bonanni, Laura

“…Agitation is a behavioral syndrome characterized by increased, often undirected, motor activity, restlessness, aggressiveness, and emotional distress…”
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LSD-induced changes in the functional connectivity of distinct thalamic nuclei by Delli Pizzi, Stefano, Chiacchiaretta, Piero, Sestieri, Carlo, Ferretti, Antonio, Tullo, Maria Giulia, Della Penna, Stefania, Martinotti, Giovanni, Onofrj, Marco, Roseman, Leor, Timmermann, Christopher, Nutt, David J., Carhart-Harris, Robin L., Sensi, Stefano L.

“…•LSD elicits nucleus-specific changes of the thalamic functional connectivity/activity.•The pulvinar, ventrolateral (VL), and non-specific nuclei were mainly…”
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BOLD cardiorespiratory pulsatility in the brain: from noise to signal of interest by Delli Pizzi, Stefano, Gambi, Francesco, Di Pietro, Massimo, Caulo, Massimo, Sensi, Stefano L, Ferretti, Antonio

“…Functional magnetic resonance imaging (fMRI) based on the Blood Oxygen Level Dependent (BOLD) contrast has been extensively used to map brain activity and…”
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Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired or Alzheimer’s disease subjects by Ciavardelli, Domenico, Piras, Fabrizio, Consalvo, Ada, Rossi, Claudia, Zucchelli, Mirco, Di Ilio, Carmine, Frazzini, Valerio, Caltagirone, Carlo, Spalletta, Gianfranco, Sensi, Stefano L

“…Abstract Aging, amyloid deposition, and tau-related pathology are key contributors to the onset and progression of Alzheimer’s disease (AD). However, AD is…”
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Editorial: Excitotoxicity Turns 50. The Death That Never Dies by Granzotto, Alberto, Weiss, John H, Sensi, Stefano L

“…The review highlights three major findings: (1) the discovery of redox-dependent modulatory sites of NMDAR, (2) the oxidative-driven conversion of…”
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Copper Imbalance in Alzheimer's Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating ATP7B Gene Variants by Squitti, Rosanna, Ventriglia, Mariacarla, Simonelli, Ilaria, Bonvicini, Cristian, Costa, Alfredo, Perini, Giulia, Binetti, Giuliano, Benussi, Luisa, Ghidoni, Roberta, Koch, Giacomo, Borroni, Barbara, Albanese, Alberto, Sensi, Stefano L, Rongioletti, Mauro

“…Evidence indicates that patients with Alzheimer's dementia (AD) show signs of copper (Cu) dyshomeostasis. This study aimed at evaluating the potential of Cu…”
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Is There a Risk for Semaglutide Misuse? Focus on the Food and Drug Administration's FDA Adverse Events Reporting System (FAERS) Pharmacovigilance Dataset by Chiappini, Stefania, Vickers-Smith, Rachel, Harris, Daniel, Papanti Pelletier, G Duccio, Corkery, John Martin, Guirguis, Amira, Martinotti, Giovanni, Sensi, Stefano L, Schifano, Fabrizio

“…Recent media reports commented about a possible issue of the misuse of antidiabetics related to molecules promoted as a weight-loss treatment in non-obese…”
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Mechanism and regulation of cellular zinc transport by Sekler, Israel, Sensi, Stefano L, Hershfinkel, Michal, Silverman, William F

“…Zinc is an essential cofactor for the activity and folding of up to ten percent of mammalian proteins and can modulate the function of many others. Because of…”
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