Search Results - "Senotov, A S"

Studying Signaling Pathway Activation in TRAIL-Resistant Macrophage-Like Acute Myeloid Leukemia Cells by Lomovskaya, Y V, Krasnov, K S, Kobyakova, M I, Kolotova, A A, Ermakov, A M, Senotov, A S, Fadeeva, I S, Fetisova, E I, Lomovsky, A I, Zvyagina, A I, Akatov, V S, Fadeev, R S

“…Acute myeloid leukemia (AML) is a malignant neoplasm characterized by extremely low curability and survival. The inflammatory microenvironment and maturation…”
Get full text

Myeloid Differentiation Increases Resistance of Leukemic Cells to TRAIL-Induced Death by Reducing the Expression of DR4 and DR5 Receptors by Lomovskaya, Ya. V., Kobyakova, M. I., Senotov, A. S., Fadeeva, I. S., Lomovsky, A. I., Krasnov, K. S., Shtatnova, D. Yu, Akatov, V. S., Fadeev, R. S.

“…The study of the mechanisms of resistance of tumor cells to TRAIL-induced death remains an urgent task since this cytokine is an important highly selective…”
Get full text

Reversible Increase in Resistance of A-431 Carcinoma Cells to TRAIL-Induced Apoptosis in Confluent Cultures Corresponds to a Decrease in Expression of DR4 and DR5 Receptors by Fadeev, R. S., Dolgikh, N. V., Chekanov, A. V., Senotov, A. S., Krasnov, K. S., Kobyakova, M. I., Lomovskaya, Ya. V., Fadeeva, I. S., Akatov, V. S.

“…— TRAIL (TNF alpha Related Apoptosis Inducing Ligand) cytokine is of great interest for the development of targeted antitumor drugs. We have previously found a…”
Get full text

Appearance of Signs of Differentiation and Pro-inflammatory Phenotype in Acute Myeloid Leukemia Cells THP-1 with an Increase in Their TRAIL Resistance in Cell Aggregates in Vitro by Kobyakova, M. I., Evstratova, Ya. V., Senotov, A. S., Lomovsky, A. I., Minaichev, V. V., Zvyagina, A. I., Solovieva, M. E., Fadeeva, I. S., Akatov, V. S., Fadeev, R. S.

“…Previously, we found a significant increase in TRAIL (TNFα-related apoptosis-inducing ligand) resistance of acute myeloid leukemia (AML) cells in multicellular…”
Get full text

Inhibition of NF-kB Activation Decreases Resistance in Acute Myeloid Leukemia Cells to TRAIL-induced Apoptosis in Multicellular Aggregates by Fadeev, R S, Solovieva, M E, Slyadovskiy, D A, Zakharov, S G, Fadeeva, I S, Senotov, A S, Golenkov, A K, Akatov, V S

“…Suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates, was studied using small molecule inhibitors…”
Get more information

INCREASE OF DRUG RESISTANCE OF ACUTE MYELOID LEUKEMIA CELLS IN MULTICELLULAR AGGREGATES IN VITRO by Zakharov, S. G., Golenkov, A. K., Mitina, T. A., Lutskaya, T. D., Belousov, K. A., Fadeev, R. S., Solovieva, M. E., Senotov, A. S., Akatov, V. S.

“…Background: Therapeutic efficiency in treatment of acute myeloid leukemia (AML) ranges from 20 to 45%. One of the causes of the latter is a drug resistance…”
Get full text

Cell aggregation increases drug resistance of acute myeloid leukemia cells by Fadeev, R. S., Solovieva, M. E., Slyadovskiy, D. A., Zakharov, S. G., Fadeeva, I. S., Senotov, A. S., Dolgikh, N. V., Golenkov, A. K., Akatov, V. S.

“…One of the major causes of low efficiency of the therapy for acute myeloid leukemia is drug resistance of leukemic cells. Microenvironment plays a key role in…”
Get full text

Monocyte-Macrophage Differentiation Suppresses the Expression of Proapoptotic Receptors to Apo2L/TRAIL and Increases Resistance to TRAIL-Induced Apoptosis by Evstratova, Y. V., Kobyakova, M. I., Novikova, V. V., Senotov, A. S., Akatov, V. S., Fadeev, R. S.

“…—A comparative study of the expression of pro- and anti-apoptotic receptors to cytokine TRAIL (TNF-related apoptosis-inducing ligand) on immature blast cells…”
Get full text

A Study of the Macrophage Differentiation of Acute Myeloid Leukemia Cells in Multicellular Aggregates by Kobyakova, M. I., Evstratova, Ya. V., Senotov, A. S., Lomovsky, A. I., Novikova, V. V., Krasnov, K. S., Fadeeva, I. S., Akatov, V. S., Fadeev, R. S.

“…—The resistance of leukemic cells to the action of chemotherapeutic drugs is the main reason for insufficient efficacy in the treatment of acute myeloid…”
Get full text

The inhibition of NF-kB activation decreases the resistance of acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates by Fadeev, R. S., Solovieva, M. E., Slyadovskiy, D. A., Zakharov, S. G., Fadeeva, I. S., Senotov, A. S., Golenkov, A. K., Akatov, V. S.

“…The suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates was studied using small molecular…”
Get full text