Search Results - "Senol Deniz, F. Sezer"

Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2? by Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer

“…New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic (COVID-19) declared by WHO. Coronavirus disease 2019 (COVID-19) is an infectious disease…”
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Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors by Senol Deniz, F Sezer, Eren, Gokcen, Orhan, Ilkay Erdogan, Sener, Bilge, Ozgen, Ufuk, Aldaba, Randa, Calis, Ihsan

“…Cholinesterase (ChE) inhibition is an important treatment strategy for Alzheimer's disease (AD) as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)…”
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Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth by Ślusarczyk, Sylwester, Senol Deniz, F Sezer, Abel, Renata, Pecio, Łukasz, Pérez-Sánchez, Horacio, Cerón-Carrasco, José P, den-Haan, Helena, Banerjee, Priyanka, Preissner, Robert, Krzyżak, Edward, Oleszek, Wiesław, E Orhan, Ilkay, Matkowski, Adam

“…Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related…”
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Profiling Auspicious Butyrylcholinesterase Inhibitory Activity of Two Herbal Molecules: Hyperforin and Hyuganin C by Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer, Trædal‐Henden, Steinar, Cerón‐Carrasco, José P., den Haan, Helena, Peña‐García, Jorge, Pérez‐Sánchez, Horacio, Emerce, Esra, Skalicka‐Wozniak, Krystyna

“…Cholinergic therapy based on cholinesterase (ChE) inhibitory drugs is the mainstay for the treatment of Alzheimer's disease. Therefore, an extensive research…”
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In vitro and in silico cholinesterase inhibitory and antioxidant effects of essential oils and extracts of two new Salvia fruticosa mill. cultivars (Turgut and Uysal) and GC-MS analysis of the essential oils by Abacı, Nurten, Senol Deniz, F. Sezer, Ekhteiari Salmas, Ramin, Uysal Bayar, Fatma, Turgut, Kenan, Orhan, Ilkay Erdogan

“…The EtOH extracts of the leaves of two new cultivars (Uysal-SFU and Turgut-SFT) of Salvia fruticosa Mill. was tested against acetylcholinesterase (IC50: 30.62…”
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Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives by Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer, Salmas, Ramin Ekhteiari, Durdagi, Serdar, Epifano, Francesco, Genovese, Salvatore, Fiorito, Serena

“…[Display omitted] •26 O-alkylcoumarins were synthesized and tested at 100 µM for their in vitro inhibitory potential against cholinesterases.•12 of them…”
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Novel pyridazinone derivatives as butyrylcholinesterase inhibitors by Dundar, Yasemin, Kuyrukcu, Ozge, Eren, Gokcen, Senol Deniz, F. Sezer, Onkol, Tijen, Orhan, Ilkay Erdogan

“…[Display omitted] •Novel [3-substitue-6-oxopyridazin-1(6H)-yl]methyl carbamate derivatives were synthesized.•Compounds 7c, 14c, and 16c showed significant…”
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Evaluation of Anti‐Alzheimer Activity of Synthetic Coumarins by Combination of in Vitro and in Silico Approaches by Erdogan Orhan, Ilkay, Deniz, F. Sezer Senol, Salmas, Ramin Ekhteiari, Irmak, Sule, Acar, Ozden Ozgun, Turgut, Gurbet Celik, Sen, Alaattin, Zbancioc, Ana‐Maria, Luca, Simon Vlad, Skiba, Adrianna, Skalicka‐Woźniak, Krystyna, Tataringa, Gabriela

“…Series of synthetic coumarin derivatives (1‐16) were tested against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes linked to the…”
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Cholinesterase Inhibitory and In Silic o Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids - Berberine as the Lead Compound by Senol Deniz, F Sezer, Ekhteiari Salmas, Ramin, Emerce, Esra, Sener, Bilge, Orhan, Ilkay Erdogan

“…Cholinesterase (ChE) inhibitors used currently in clinics for the treatment of Alzheimer's disease (AD) are the most prescribed drug class with…”
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Erodium birandianum Ilarslan & Yurdak. shows anti-gout effect through xanthine oxidase inhibition: Combination of in vitro and in silico techniques and profiling of main components by LC-Q-ToF-MS by Baki Kekilli, Elif, Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer, Eren, Gokcen, Emerce, Esra, Kahraman, Ahmet, Aysal, I. Ayhan

“…[Display omitted] •Anti-gout effect of E. birandianum was examined via xanthine oxidase inhibition.•The ethanol extract of the plant showed 82.26 ± 0.10 % of…”
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Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders by Anil Kumar, Nanjangud V., Quispe, Cristina, Herrera-Bravo, Jesús, Herrera Belén, Lisandra, Loren, Pía, Salazar, Luis A., Silva, Victor, Erdogan Orhan, Ilkay, Senol Deniz, F. Sezer, Nemli, Elifsu, Capanoglu, Esra, Olatunde, Ahmed, Cristina Cirone Silva, Nathália, Zivkovic, Jelena, Shorog, Eman M., Calina, Daniela, Sharifi-Rad, Javad

“…Mushrooms have long been revered not only as a staple food source but also for their potential medicinal properties. Their role as a natural repository of…”
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Golden Pigment Curcumin: An Inspiring Antiviral Molecular Model for COVID-19 Drug Design by Erdoğan Orhan,İlkay, Şenol Deniz,Fatma Sezer

“…COVID-19 caused by a new type of coronavirus (SARS-CoV-2) originated in China has speedily become a frightening pandemic all over the world. Despite of intense…”
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Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma by Ślusarczyk, Sylwester, Senol Deniz, F. Sezer, Woźniak, Dorota, Pecio, Łukasz, Pérez-Sánchez, Horacio, Cerón-Carrasco, José P., Stochmal, Anna, den-Haan Alonso, Helena, Matkowski, Adam, Orhan, Ilkay Erdogan

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Exploration of anti-tyrosinase effect of Geranium glaberrimum Boiss. & Heldr. with in silico approach and survey of 21 Geranium species by Celikler Ozer, Ovgu, Orhan, Ilkay Erdogan, Çalışkan, Burcu, Senol Deniz, F. Sezer, Gokbulut, Alper, Gur Maz, Tugçe, Aysal, Ayhan, Emerce, Esra, Shekfeh, Suhaib, Kahraman, Ahmet, Banoglu, Erden

“…[Display omitted] •21 Geranium sp. were investigated for their tyrosinase inhibitory and antioxidant activity.•The 2nd fraction (GG-2) resulted in the highest…”
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Synthesis, biological evaluation and computational investigations of S-benzyl dithiocarbamates as the cholinesterase and monoamine oxidase inhibitors by Khan, Bilal Ahmad, Hamdani, Syeda Shamila, Alsfouk, Bshra A., Ejaz, Syeda Abida, Aziz, Mubashir, Channar, Pervaiz Ali, Deniz, F. Sezer Senol, Orhan, Ilkay Erdogan, Hameed, Shahid, Saeed, Aamer, Jalil, Saquib, Iqbal, Jamshed

“…•Synthesis of S-benzyl dithiocarbamates derivatives via a single pot reaction setup.•Characterization of synthesized derivatives via NMR (1H and 13C), FT-IR…”
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Evaluation of Selected Plant Phenolics via Beta-Secretase-1 Inhibition, Molecular Docking, and Gene Expression Related to Alzheimer’s Disease by Uçar Akyürek, Tugba, Orhan, Ilkay Erdogan, Şenol Deniz, F. Sezer, Eren, Gokcen, Acar, Busra, Sen, Alaattin

“…Background: The goal of the current study was to investigate the inhibitory activity of six phenolic compounds, i.e., rosmarinic acid, gallic acid, oleuropein,…”
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