Search Results - "Senol, F. Sezer"

Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2? by Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer

“…New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic (COVID-19) declared by WHO. Coronavirus disease 2019 (COVID-19) is an infectious disease…”
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Designing Multi-Targeted Therapeutics for the Treatment of Alzheimer's Disease by Orhan, Ilkay Erdogan, Senol, F Sezer

“…Due to multi-faceted pathology of AD; no drug can seize the progress of the disease, whereas only the symptomatic treatment is available at the moment. Several…”
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Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors by Senol Deniz, F Sezer, Eren, Gokcen, Orhan, Ilkay Erdogan, Sener, Bilge, Ozgen, Ufuk, Aldaba, Randa, Calis, Ihsan

“…Cholinesterase (ChE) inhibition is an important treatment strategy for Alzheimer's disease (AD) as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)…”
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Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth by Ślusarczyk, Sylwester, Senol Deniz, F Sezer, Abel, Renata, Pecio, Łukasz, Pérez-Sánchez, Horacio, Cerón-Carrasco, José P, den-Haan, Helena, Banerjee, Priyanka, Preissner, Robert, Krzyżak, Edward, Oleszek, Wiesław, E Orhan, Ilkay, Matkowski, Adam

“…Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related…”
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Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions by Erdogan Orhan, Ilkay, Senol, F. Sezer, Ozturk, Nilgun, Celik, Sadiye Ayse, Pulur, Aysen, Kan, Yuksel

“…•The extracts of two dill samples were screened against cholinesterases and tyrosinase.•The ethanol extracts showed better antioxidant and…”
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Evaluation of Anti‐Alzheimer Activity of Synthetic Coumarins by Combination of in Vitro and in Silico Approaches by Erdogan Orhan, Ilkay, Deniz, F. Sezer Senol, Salmas, Ramin Ekhteiari, Irmak, Sule, Acar, Ozden Ozgun, Turgut, Gurbet Celik, Sen, Alaattin, Zbancioc, Ana‐Maria, Luca, Simon Vlad, Skiba, Adrianna, Skalicka‐Woźniak, Krystyna, Tataringa, Gabriela

“…Series of synthetic coumarin derivatives (1‐16) were tested against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes linked to the…”
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Profiling Auspicious Butyrylcholinesterase Inhibitory Activity of Two Herbal Molecules: Hyperforin and Hyuganin C by Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer, Trædal‐Henden, Steinar, Cerón‐Carrasco, José P., den Haan, Helena, Peña‐García, Jorge, Pérez‐Sánchez, Horacio, Emerce, Esra, Skalicka‐Wozniak, Krystyna

“…Cholinergic therapy based on cholinesterase (ChE) inhibitory drugs is the mainstay for the treatment of Alzheimer's disease. Therefore, an extensive research…”
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Exploring in vitro neurobiological effects and high-pressure liquid chromatography-assisted quantitation of chlorogenic acid in 18 Turkish coffee brands by Erdem, Sinem Aslan, Senol, F. Sezer, Budakoglu, Esin, Orhan, Ilkay Erdogan, Sener, Bilge

“…The hydroalcoholic extracts of the Turkish traditional coffee samples from 18 commercial brands were tested for their neurobiological effects through enzyme…”
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In vitro and in silico cholinesterase inhibitory and antioxidant effects of essential oils and extracts of two new Salvia fruticosa mill. cultivars (Turgut and Uysal) and GC-MS analysis of the essential oils by Abacı, Nurten, Senol Deniz, F. Sezer, Ekhteiari Salmas, Ramin, Uysal Bayar, Fatma, Turgut, Kenan, Orhan, Ilkay Erdogan

“…The EtOH extracts of the leaves of two new cultivars (Uysal-SFU and Turgut-SFT) of Salvia fruticosa Mill. was tested against acetylcholinesterase (IC50: 30.62…”
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Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives by Orhan, Ilkay Erdogan, Senol Deniz, F. Sezer, Salmas, Ramin Ekhteiari, Durdagi, Serdar, Epifano, Francesco, Genovese, Salvatore, Fiorito, Serena

“…[Display omitted] •26 O-alkylcoumarins were synthesized and tested at 100 µM for their in vitro inhibitory potential against cholinesterases.•12 of them…”
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Prospective neurobiological effects of the aerial and root extracts and some pure compounds of randomly selected Scorzonera species by Senol, F Sezer, Acikara, Ozlem Bahadir, Citoglu, Gulcin Saltan, Orhan, Ilkay Erdogan, Dall' Acqua, Stefano, Ozgökce, Fevzi

“…Scorzonera L. species (Asteraceae) are edible and as medicinal plants are used for various purposed in folk medicine. The methanol extracts of the aerial parts…”
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Novel pyridazinone derivatives as butyrylcholinesterase inhibitors by Dundar, Yasemin, Kuyrukcu, Ozge, Eren, Gokcen, Senol Deniz, F. Sezer, Onkol, Tijen, Orhan, Ilkay Erdogan

“…[Display omitted] •Novel [3-substitue-6-oxopyridazin-1(6H)-yl]methyl carbamate derivatives were synthesized.•Compounds 7c, 14c, and 16c showed significant…”
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In silico approach to inhibition of tyrosinase by ascorbic acid using molecular docking simulations by Senol, F Sezer, Khan, M Tareq Hassan, Orhan, Gurdal, Gurkas, Erdem, Orhan, Ilkay Erdogan, Oztekin, Nese Subutay, Ak, Fikri

“…Current evidence suggests that endogenous dopamine may act as a neurotoxin following its oxidation to an oquinone and reaction with cellular thiols, which are…”
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Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives by Orhan, Ilkay Erdogan, Jedrejek, Dariusz, Senol, F. Sezer, Salmas, Ramin Ekhteiari, Durdagi, Serdar, Kowalska, Iwona, Pecio, Lukasz, Oleszek, Wieslaw

“…Many natural products, particularly phenolic compounds, have been reported to have a strong inhibition against acetylcholinesterase (AChE) and…”
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Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L by Senol, F. Sezer, Ślusarczyk, Sylwester, Matkowski, Adam, Pérez-Garrido, Alfonso, Girón-Rodríguez, Francisco, Cerón-Carrasco, José P., den-Haan, Helena, Peña-García, Jorge, Pérez-Sánchez, Horacio, Domaradzki, Krzysztof, Orhan, Ilkay Erdogan

“…Cholinesterase inhibition is one of the most treatment strategies against Alzheimer's disease (AD) where metal accumulation is also strongly associated with…”
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Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities by Şenol, F. Sezer, Orhan, Ilkay, Celep, Ferhat, Kahraman, Ahmet, Doğan, Musa, Yilmaz, Gülderen, Şener, Bilge

“…In the current work, our target was to screen inhibitory potentials of 55 Turkish Salvia taxa, 28 of which are endemic, against acetylcholinesterase (AChE),…”
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Neuroprotective potential of some terebinth coffee brands and the unprocessed fruits of Pistacia terebinthus L. and their fatty and essential oil analyses by Orhan, Ilkay Erdogan, Senol, F. Sezer, Gulpinar, A. Rifat, Sekeroglu, Nazim, Kartal, Murat, Sener, Bilge

“…► Neuroprotective effect of terebinth coffees and the fruits of P. terebinthus were investigated. ► Oleic acid was identified as the major fatty acid in the…”
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Cholinesterase Inhibitory and In Silic o Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids - Berberine as the Lead Compound by Senol Deniz, F Sezer, Ekhteiari Salmas, Ramin, Emerce, Esra, Sener, Bilge, Orhan, Ilkay Erdogan

“…Cholinesterase (ChE) inhibitors used currently in clinics for the treatment of Alzheimer's disease (AD) are the most prescribed drug class with…”
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In vitro prospective effects of various traditional herbal coffees consumed in Anatolia linked to neurodegeneration by Sekeroglu, Nazim, Senol, F. Sezer, Orhan, Ilkay Erdogan, Gulpinar, A. Rifat, Kartal, Murat, Sener, Bilge

“…Various herbal coffee varieties are consumed traditionally in Turkey. In the current study, the ethanol extracts of the coffee and seed samples obtained from…”
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Memory-vitalizing effect of twenty-five medicinal and edible plants and their isolated compounds by Sezer Senol, F., Orhan, Ilkay Erdogan, Ozgen, Ufuk, Renda, Gulin, Bulut, Gokhan, Guven, Leyla, Karaoglan, Esen Sezen, Sevindik, Handan G., Skalicka-Wozniak, Krystyna, Koca Caliskan, Ufuk, Sekeroglu, Nazim

“…The extracts from 25 plant species from Salvia, Hypericum, Onosma, Thymus, Origanum, Rosa, and Prunus with eight isolated compounds were screened for their…”
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