Search Results - "Senneff, Thomas C."

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  1. 1

    Site-specific effects of neurosteroids on GABAA receptor activation and desensitization by Sugasawa, Yusuke, Cheng, Wayland WL, Bracamontes, John R, Chen, Zi-Wei, Wang, Lei, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Krishnan, Kathiresan, Reichert, David E, Covey, Douglas F, Akk, Gustav, Evers, Alex S

    Published in eLife (21-09-2020)
    “…This study examines how site-specific binding to three identified neurosteroid-binding sites in the α 1 β 3 GABA A receptor (GABA A R) contributes to…”
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    Journal Article
  2. 2

    Steady‐state activation and modulation of the synaptic‐type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands by Germann, Allison L., Pierce, Spencer R., Senneff, Thomas C., Burbridge, Ariel B., Steinbach, Joe Henry, Akk, Gustav

    Published in Physiological reports (01-09-2019)
    “…The synaptic α1β2γ2 GABAA receptor is activated phasically by presynaptically released GABA. The receptor is considered to be inactive between synaptic events…”
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    Journal Article
  3. 3

    Steady-state activation of the high-affinity isoform of the α4β2δ GABAA receptor by Pierce, Spencer R., Senneff, Thomas C., Germann, Allison L., Akk, Gustav

    Published in Scientific reports (05-11-2019)
    “…Activation of GABA A receptors consisting of α4, β2 (or β3), and δ subunits is a major contributor to tonic inhibition in several brain regions. The goal of…”
    Get full text
    Journal Article
  4. 4

    Site-specific effects of neurosteroids on GABA A receptor activation and desensitization by Sugasawa, Yusuke, Cheng, Wayland Wl, Bracamontes, John R, Chen, Zi-Wei, Wang, Lei, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Krishnan, Kathiresan, Reichert, David E, Covey, Douglas F, Akk, Gustav, Evers, Alex S

    Published in eLife (21-09-2020)
    “…This study examines how site-specific binding to three identified neurosteroid-binding sites in the α β GABA receptor (GABA R) contributes to neurosteroid…”
    Get full text
    Journal Article
  5. 5

    Steady‐state activation and modulation of the synaptic‐type α 1 β 2 γ 2L GABA A receptor by combinations of physiological and clinical ligands by Germann, Allison L., Pierce, Spencer R., Senneff, Thomas C., Burbridge, Ariel B., Steinbach, Joe Henry, Akk, Gustav

    Published in Physiological reports (01-09-2019)
    “…The synaptic α1β2γ2 GABAA receptor is activated phasically by presynaptically released GABA. The receptor is considered to be inactive between synaptic events…”
    Get full text
    Journal Article
  6. 6

    Site-specific effects of neurosteroids on GABA.sub.A receptor activation and desensitization by Sugasawa, Yusuke, Cheng, Wayland W.L, Bracamontes, John R, Chen, Zi-Wei, Wang, Lei, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Krishnan, Kathiresan, Reichert, David E, Covey, Douglas F, Akk, Gustav, Evers, Alex S

    Published in eLife (21-09-2020)
    “…This study examines how site-specific binding to three identified neurosteroid-binding sites in the [alpha].sub.1[beta].sub.3 GABA.sub.A receptor (GABA.sub.AR)…”
    Get full text
    Journal Article
  7. 7

    Steady-state activation of the high-affinity isoform of the α4β2δ GABA A receptor by Pierce, Spencer R, Senneff, Thomas C, Germann, Allison L, Akk, Gustav

    Published in Scientific reports (05-11-2019)
    “…Activation of GABA receptors consisting of α4, β2 (or β3), and δ subunits is a major contributor to tonic inhibition in several brain regions. The goal of this…”
    Get full text
    Journal Article
  8. 8

    Steady-state activation and modulation of the synaptic-type α1β2γ2L GABA A receptor by combinations of physiological and clinical ligands by Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Burbridge, Ariel B, Steinbach, Joe Henry, Akk, Gustav

    Published in Physiological reports (01-09-2019)
    “…The synaptic α1β2γ2 GABA receptor is activated phasically by presynaptically released GABA. The receptor is considered to be inactive between synaptic events…”
    Get full text
    Journal Article