Search Results - "Sengupta, Pallabi"

The Molecular Tête‐à‐Tête between G‐Quadruplexes and the i‐motif in the Human Genome by Sengupta, Pallabi, Bose, Debopriya, Chatterjee, Subhrangsu

“…G‐Quadruplex (GQ) and i‐motif structures are the paradigmatic examples of nonclassical tetrastranded nucleic acids having multifarious biological functions and…”
Get full text

In Silico Screening and Binding Characterization of Small Molecules toward a G‑Quadruplex Structure Formed in the Promoter Region of c‑MYC Oncogene by Bhat, Jyotsna, Mondal, Soma, Sengupta, Pallabi, Chatterjee, Subhrangsu

“…Overexpression of c-MYC oncogene is associated with cancer pathology. Expression of c-MYC is regulated by the G-quadruplex structure formed in the G-rich…”
Get full text

Inosine 5′-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding by Sengupta, Pallabi, Chatterjee, Subhrangsu

“…The transcription-inhibitory G-Quadruplex(Pu27-GQ) at c-MYC promoter is challenging to target due to structural heterogeneity. Nucleoside diphosphate kinase…”
Get full text

Truncated G‑Quadruplex Isomers Cross-Talk with the Transcription Factors To Maintain Homeostatic Equilibria in c‑MYC Transcription by Sengupta, Pallabi, Bhattacharya, Apoorva, Sa, Gaurisankar, Das, Tanya, Chatterjee, Subhrangsu

“…The nuclease hypersensitive element III1 (NHE III1) upstream c-MYC promoter harbors a transcription-silencing G-quadruplex (Pu27) element. Dynamic turnover of…”
Get full text

G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment by Sengupta, Pallabi, Chattopadhyay, Samit, Chatterjee, Subhrangsu

“…•The atomic-level structures of G-quadruplexes in BCL-2 promoter/transcripts are described.•G-quadruplexes contribute to cellular processes and oncogenic…”
Get full text

Switchable tetraplex elements in the heterogeneous nuclear ribonucleoprotein K promoter: micro-environment dictated structural transitions of G/C rich elements by Bose, Debopriya, Banerjee, Nilanjan, Roy, Ananya, Sengupta, Pallabi, Chatterjee, Subhrangsu

“…We have elucidated the hnRNP K promoter as a hotspot for tetraplex-based molecular switches receptive to micro-environmental stimuli. We have characterised the…”
Get full text

Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions by Jana, Jagannath, Mondal, Soma, Bhattacharjee, Payel, Sengupta, Pallabi, Roychowdhury, Tanaya, Saha, Pranay, Kundu, Pallob, Chatterjee, Subhrangsu

“…A putative anticancer plant alkaloid, Chelerythrine binds to G-quadruplexes at promoters of VEGFA, BCL2 and KRAS genes and down regulates their expression. The…”
Get full text

Long non-coding intergenic RNA, LINC00273 induces cancer metastasis and stemness via miRNA sponging in triple negative breast cancer by Sengupta, Pallabi, Roy, Ananya, Roy, Laboni, Bose, Debopriya, Halder, Satyajit, Jana, Kuladip, Mukherjee, Gopeswar, Chatterjee, Subhrangsu

“…LncRNAs and miRNAs, being the master regulators of gene expression, are crucial functional mediators in cancer. Our study unveils the critical regulatory role…”
Get full text

Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells by Sengupta, Pallabi, Banerjee, Nilanjan, Roychowdhury, Tanaya, Dutta, Anindya, Chattopadhyay, Samit, Chatterjee, Subhrangsu

“…Abstract c-MYC proto-oncogene harbours a transcription-inhibitory quadruplex-forming scaffold (Pu27) upstream P1 promoter providing anti-neoplastic therapeutic…”
Get full text

Promoter G-quadruplex favours epigenetic reprogramming-induced atypical expression of ZEB1 in cancer cells by Dutta, Anindya, Maji, Nilanjana, Sengupta, Pallabi, Banerjee, Nilanjan, Kar, Swarnali, Mukherjee, Gopeswar, Chatterjee, Subhrangsu, Basu, Moitri

“…Aberrant expression of Zinc-finger E-box binding homeobox 1 (ZEB1), which remains repressed in normal cells, is frequently associated with cancer…”
Get full text

Spatial Position Regulates Power of Tryptophan: Discovery of a Major-Groove-Specific Nuclear-Localizing, Cell-Penetrating Tetrapeptide by Bhunia, Debmalya, Mondal, Prasenjit, Das, Gaurav, Saha, Abhijit, Sengupta, Pallabi, Jana, Jagannath, Mohapatra, Saswat, Chatterjee, Subhrangsu, Ghosh, Surajit

“…Identification of key amino acids is required for development of efficient cell-penetrating peptides (CPPs) and has tremendous implications in medicine…”
Get full text

Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent by Mondal, Soma, Jana, Jagannath, Sengupta, Pallabi, Jana, Samarjit, Chatterjee, Subhrangsu

“…The use of small molecules to arrest G-quadruplex structure has become a potential strategy for the development and design of a new class of anticancer…”
Get more information

G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer by Sengupta, Pallabi, Dutta, Anindya, Suseela, Y. V., Roychowdhury, Tanaya, Banerjee, Nilanjan, Dutta, Ananya, Halder, Satyajit, Jana, Kuladip, Mukherjee, Gopeswar, Chattopadhyay, Samit, Govindaraju, Thimmaiah, Chatterjee, Subhrangsu

“…P38γ (MAPK12) is predominantly expressed in triple negative breast cancer cells (TNBC) and induces stem cell (CSC) expansion resulting in decreased survival of…”
Get full text

Restriction of telomerase capping by short non-toxic peptides via arresting telomeric G-quadruplex by Jana, Jagannath, Sengupta, Pallabi, Mondal, Soma, Chatterjee, Subhrangsu

“…The stabilization of a G-quadruplex structure in human telomeric DNA has become a promising strategy in the development of cancer therapeutics. Here, we report…”
Get full text

The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels by Dutta, Parul, Islam, Sehbanul, Choppara, Srinadh, Sengupta, Pallabi, Kumar, Anil, Kumar, Avinash, Wani, Mohan R., Chatterjee, Subhrangsu, Santra, Manas Kumar

“…F-box protein 31 (FBXO31) is a reported putative tumor suppressor, and its inactivation due to loss of heterozygosity is associated with cancers of different…”
Get full text

A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression by Deiana, Marco, Andrés Castán, José María, Josse, Pierre, Kahsay, Abraha, Sánchez, Darío Puchán, Morice, Korentin, Gillet, Natacha, Ravindranath, Ranjitha, Patel, Ankit Kumar, Sengupta, Pallabi, Obi, Ikenna, Rodriguez-Marquez, Eva, Khrouz, Lhoussain, Dumont, Elise, Abad Galán, Laura, Allain, Magali, Walker, Bright, Ahn, Hyun Seo, Maury, Olivier, Blanchard, Philippe, Le Bahers, Tangui, Öhlund, Daniel, von Hofsten, Jonas, Monnereau, Cyrille, Cabanetos, Clément, Sabouri, Nasim

“…Abstract Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and photoactivation of a photosensitizer (PS) into diseased…”
Get full text

Targeting Oncogene Promoters and Ribosomal RNA Biogenesis by G‑Quadruplex Binding Ligands Translate to Anticancer Activity by Venkata Suseela, Yelisetty, Sengupta, Pallabi, Roychowdhury, Tanaya, Panda, Suman, Talukdar, Sangita, Chattopadhyay, Samit, Chatterjee, Subhrangsu, Govindaraju, Thimmaiah

“…G-Quadruplex (GQ) nucleic acids are promising therapeutic targets in anticancer research due to their structural robustness, polymorphism, and gene-regulatory…”
Get full text

Traces of statistical learning in the brain's functional connectivity after artificial language exposure by Sengupta, Pallabi, Burgaleta, Miguel, Zamora-López, Gorka, Basora, Anna, Sanjuán, Ana, Deco, Gustavo, Sebastian-Galles, Nuria

“…Our environment is full of statistical regularities, and we are attuned to learn about these regularities by employing Statistical Learning (SL), a…”
Get full text

SMAR1 inhibits Wnt/β-catenin signaling and prevents colorectal cancer progression by Taye, Nandaraj, Alam, Aftab, Ghorai, Suvankar, Chatterji, Deya Ghosh, Parulekar, Apoorva, Mogare, Devraj, Singh, Snahlata, Sengupta, Pallabi, Chatterjee, Subhrangsu, Bhat, Manoj Kumar, Santra, Manas Kumar, Salunkhe, Prabhakar Budha, Finston, Susan Kling, Chattopadhyay, Samit

“…Reduced expression of Scaffold/Matrix Attachment Region Binding Protein 1 (SMAR1) is associated with various cancers resulting in poor prognosis of the…”
Get full text

LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness by Jana, Samarjit, Jana, Jagannath, Patra, Kartick, Mondal, Soma, Bhat, Jyotsna, Sarkar, Arnab, Sengupta, Pallabi, Biswas, Anindya, Mukherjee, Meghomukta, Tripathi, Satya Prakash, Gangwal, Rahul, Hazra, Joyita, Sangamwar, Abhay T, Mukherjee, Gopeswar, Bhattacharjee, Shamee, Mandal, Deba Prasad, Chatterjee, Subhrangsu

“…Discovery of anti-metastatic drugs is of immense clinical significance as metastasis is responsible for 90% of all cancer deaths. Here we report the inhibitory…”
Get full text