Search Results - "Sengillo, Jesse D"

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration by Winkler, Ethan A, Nishida, Yoichiro, Sagare, Abhay P, Rege, Sanket V, Bell, Robert D, Perlmutter, David, Sengillo, Jesse D, Hillman, Sara, Kong, Pan, Nelson, Amy R, Sullivan, John S, Zhao, Zhen, Meiselman, Herbert J, Wenby, Rosalinda B, Soto, Jamie, Abel, E Dale, Makshanoff, Jacob, Zuniga, Edward, De Vivo, Darryl C, Zlokovic, Berislav V

“…Winkler et al . show that the glucose transporter GLUT1 in brain endothelium is necessary for the maintenance of proper brain capillary networks and…”
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Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis by Winkler, Ethan A., Sengillo, Jesse D., Sullivan, John S., Henkel, Jenny S., Appel, Stanley H., Zlokovic, Berislav V.

“…The blood–brain barrier and blood–spinal cord barrier (BSCB) limit the entry of plasma components and erythrocytes into the central nervous system (CNS)…”
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Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability by Winkler, Ethan A, Sengillo, Jesse D, Bell, Robert D, Wang, Joseph, Zlokovic, Berislav V

“…The blood–spinal cord barrier (BSCB) regulates molecular exchange between blood and spinal cord. Pericytes are presumed to be important cellular constituents…”
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Blood—spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice by Winkler, Ethan A., Sengillo, Jesse D., Sagare, Abhay P., Zhao, Zhen, Ma, Qingyi, Zuniga, Edward, Wang, Yaoming, Zhong, Zhihui, Sullivan, John S., Griffin, John H., Cleveland, Don W., Zlokovic, Berislav V.

“…Humans with ALS and transgenic rodents expressing ALS-associated superoxide dismutase (SOD1) mutations develop spontaneous blood-spinal cord barrier (BSCB)…”
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HTRA1, an age‐related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1 by Lin, Michael K., Yang, Jin, Hsu, Chun Wei, Gore, Anuradha, Bassuk, Alexander G., Brown, Lewis M., Colligan, Ryan, Sengillo, Jesse D., Mahajan, Vinit B., Tsang, Stephen H.

“…Summary High‐temperature requirement protein A1 (HTRA1) is a serine protease secreted by a number of tissues including retinal pigment epithelium (RPE). A…”
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Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration by Wert, Katherine J., Velez, Gabriel, Kanchustambham, Vijaya L., Shankar, Vishnu, Evans, Lucy P., Sengillo, Jesse D., Zare, Richard N., Bassuk, Alexander G., Tsang, Stephen H., Mahajan, Vinit B.

“…Neurodegenerative diseases are incurable disorders caused by progressive neuronal cell death. Retinitis pigmentosa (RP) is a blinding neurodegenerative disease…”
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Efficacy of rituximab in non-paraneoplastic autoimmune retinopathy by Boudreault, Katherine, Justus, Sally, Sengillo, Jesse D, Schuerch, Kaspar, Lee, Winston, Cabral, Thiago, Tsang, Stephen H

“…Autoimmune retinopathy (AIR) is a rare but potentially blinding condition that is often underdiagnosed. Common features in AIR presentation include rapidly…”
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Endophthalmitis caused by Burkholderia cepacia complex (BCC): clinical characteristics, antibiotic susceptibilities, and treatment outcomes by Beca, Flavius A., Sengillo, Jesse D., Robles-Holmes, Hailey K., Iyer, Prashanth G., Miller, Darlene, Yannuzzi, Nicolas A., Flynn, Harry W.

“…Purpose To report the clinical characteristics, antibiotic susceptibilities, and review the literature of Burkholderia cepacia complex ( BCC ) associated…”
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Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity by Liu, Katherine Y, Sengillo, Jesse D, Velez, Gabriel, Jauregui, Ruben, Sakai, Lynn Y, Maumenee, Irene H, Bassuk, Alexander G, Mahajan, Vinit B, Tsang, Stephen H

“…SLIT2 is a protein ligand for the Roundabout (ROBO) receptor and was found to play a major role in repulsive midline axon guidance in central nervous system…”
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Transient vision loss associated with paracentral acute middle maculopathy detected on multi-modal imaging by Sengillo, Jesse D., Zhang, Lily, Sridhar, Jayanth, Flynn, Harry W., Schwartz, Stephen G.

“…To report two patients with transient decreased vision and associated paracentral acute middle maculopathy (PAMM) lesions identified with multi-modal imaging,…”
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Characterization of Pseudomonas aeruginosa isolates from patients with endophthalmitis using conventional microbiologic techniques and whole genome sequencing by Sengillo, Jesse D., Duker, Jacob, Hernandez, Maribel, Maestre, Jorge, Reyes-Capo, Daniela, Patel, Annika, Watane, Arjun, Patel, Nimesh A., Yannuzzi, Nicolas A., Miller, Darlene, Flynn, Harry W.

“…Purpose To demonstrate antibiotic susceptibility and genomic virulence factor profiles of Pseudomonas aeruginosa isolates from patients with culture-confirmed…”
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Importance of Patient Advocacy During the COVID-19 Pandemic by Sengillo, Jesse D.

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Translation of CRISPR Genome Surgery to the Bedside for Retinal Diseases by Xu, Christine L, Cho, Galaxy Y, Sengillo, Jesse D, Park, Karen S, Mahajan, Vinit B, Tsang, Stephen H

“…In recent years, there has been accelerated growth of clustered regularly interspaced short palindromic repeats (CRISPR) genome surgery techniques. Genome…”
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Nutritionally variant streptococci causing endophthalmitis associated with intravitreal anti-vascular endothelial growth factor injection by Steinmetz, Robert L., Steinmetz, Carsten Z., Reyes-Capo, Daniela P., Brooks, H. Logan, Sengillo, Jesse D., Miller, Darlene, Flynn, Harry W.

“…To describe the clinical course and microbial properties of the first two reported cases of nutritionally variant Streptococci (Granulicatella adiacens and…”
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Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease by Sengillo, Jesse D., Winkler, Ethan A., Walker, Corey T., Sullivan, John S., Johnson, Mahlon, Zlokovic, Berislav V.

“…Neurovascular dysfunction contributes to Alzheimer's disease (AD). Cerebrovascular abnormalities and blood–brain barrier (BBB) damage have been shown in AD…”
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Resolution of Crystalline Retinopathy After Kidney Transplant for Hyperoxaluria by Kiryakoza, Lauren C, Sengillo, Jesse D, Berrocal, Audina M

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Multidrug-Resistant Pseudomonas aeruginosa Keratitis Associated With Artificial Tear Use by Shoji, Marissa K, Gutkind, Naomi E, Meyer, Benjamin I, Yusuf, Ramsey, Sengillo, Jesse D, Amescua, Guillermo, Miller, Darlene

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Gene and cell-based therapies for inherited retinal disorders: An update by Sengillo, Jesse D., Justus, Sally, Tsai, Yi-Ting, Cabral, Thiago, Tsang, Stephen H.

“…Retinal degenerations present a unique challenge as disease progression is irreversible and the retina has little regenerative potential. No current treatments…”
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Peripheral Retinal Nonperfusion in Pediatric Patients with Optic Disc Hypoplasia by da Cruz, Natasha F.S., Sengillo, Jesse D., Fan, Jason, Negron, Catherin I., Felder, Marley B., Berrocal, Audina M.

“…This study aims to report the association of optic nerve hypoplasia (ONH), peripheral retinal nonperfusion, and secondary complications in pediatric patients…”
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Perifoveal Chorioretinal Atrophy after Subretinal Voretigene Neparvovec-rzyl for RPE65-Mediated Leber Congenital Amaurosis by Gange, William S, Sisk, Robert A, Besirli, Cagri G, Lee, Thomas C, Havunjian, Margaret, Schwartz, Hillary, Borchert, Mark, Sengillo, Jesse D, Mendoza, Carlos, Berrocal, Audina M, Nagiel, Aaron

“…To report an anatomic change following subretinal injection of voretigene neparvovec-rzyl (VN) for RPE65-mediated Leber congenital amaurosis. Multicenter,…”
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