Search Results - "Sengers, Bram G"

The influence of placental metabolism on fatty acid transfer to the fetus by Perazzolo, Simone, Hirschmugl, Birgit, Wadsack, Christian, Desoye, Gernot, Lewis, Rohan M., Sengers, Bram G.

“…The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling…”
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Transfer and Metabolism of Cortisol by the Isolated Perfused Human Placenta by Stirrat, Laura I, Sengers, Bram G, Norman, Jane E, Homer, Natalie Z M, Andrew, Ruth, Lewis, Rohan M, Reynolds, Rebecca M

“…Abstract Context Fetal overexposure to glucocorticoids in utero is associated with fetal growth restriction and is postulated to be a key mechanism linking…”
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A scaffold-free approach to cartilage tissue generation using human embryonic stem cells by Griffith, Lauren A., Arnold, Katherine M., Sengers, Bram G., Tare, Rahul S., Houghton, Franchesca D.

“…Articular cartilage functions as a shock absorber and facilitates the free movement of joints. Currently, there are no therapeutic drugs that promote the…”
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Collective Cell Behavior in Mechanosensing of Substrate Thickness by Tusan, Camelia G., Man, Yu-Hin, Zarkoob, Hoda, Johnston, David A., Andriotis, Orestis G., Thurner, Philipp J., Yang, Shoufeng, Sander, Edward A., Gentleman, Eileen, Sengers, Bram G., Evans, Nicholas D.

“…Extracellular matrix stiffness has a profound effect on the behavior of many cell types. Adherent cells apply contractile forces to the material on which they…”
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Experimental characterization and computational modelling of two-dimensional cell spreading for skeletal regeneration by Sengers, Bram G, Please, Colin P, Oreffo, Richard O.C

“…Limited cell ingrowth is a major problem for tissue engineering and the clinical application of porous biomaterials as bone substitutes. As a first step,…”
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Serial block‐face scanning electron microscopy of erythrocytes protruding through the human placental syncytiotrophoblast by Palaiologou, Eleni, Goggin, Patricia, Chatelet, David S., Lofthouse, Emma M., Torrens, Christopher, Sengers, Bram G., Cleal, Jane K., Page, Anton, Lewis, Rohan M.

“…The syncytiotrophoblast forms a continuous barrier between the maternal and fetal circulations. Here we present a serial block‐face scanning electron…”
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3D visualization of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast by Lewis, Rohan M., Baskaran, Harikesan, Green, Jools, Tashev, Stanimir, Palaiologou, Eleni, Lofthouse, Emma M., Cleal, Jane K., Page, Anton, Chatelet, David S., Goggin, Patricia, Sengers, Bram G.

“…The placental syncytiotrophoblast, a syncytium without cell-cell junctions, is the primary barrier between the mother and the fetus. Despite no apparent…”
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Chondrogenic potential of human articular chondrocytes and skeletal stem cells: A comparative study by Li, Siwei, Sengers, Bram G, Oreffo, Richard OC, Tare, Rahul S

“…Regenerative medicine strategies have increasingly focused on skeletal stem cells (SSCs), in response to concerns such as donor site morbidity,…”
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A systems perspective on placental amino acid transport by Cleal, Jane K., Lofthouse, Emma M., Sengers, Bram G., Lewis, Rohan M.

“…Placental amino acid transfer is a complex process that is essential for fetal development. Impaired amino acid transfer causes fetal growth restriction, which…”
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Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity by Hirschmugl, Birgit, Perazzolo, Simone, Sengers, Bram G., Lewis, Rohan M., Gruber, Michael, Desoye, Gernot, Wadsack, Christian

“…Background Metabolic changes in obese pregnant women, such as changes of plasma lipids beyond physiological levels, may subsequently affect fetal development…”
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Placental perfusion and mathematical modelling by Lewis, Rohan M., Cleal, Jane K., Sengers, Bram G.

“…The isolated perfused placental cotyledon technique has led to numerous advances in placental biology. Combining placental perfusion with mathematical…”
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Placental evolution from a three-dimensional and multiscale structural perspective by Laundon, Davis, Gostling, Neil J, Sengers, Bram G, Chavatte-Palmer, Pascale, Lewis, Rohan M

“…The placenta mediates physiological exchange between the mother and the fetus. In placental mammals, all placentas are descended from a single common ancestor…”
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An integrated finite-element approach to mechanics, transport and biosynthesis in tissue engineering by Sengers, Bram G, Oomens, Cees W, Baaijens, Frank P

“…A finite-element approach was formulated, aimed at enabling an integrated study of mechanical and biochemical factors that control the functional development…”
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Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta by Lofthouse, Emma M., Torrens, Christopher, Manousopoulou, Antigoni, Nahar, Monica, Cleal, Jane K., O'Kelly, M. Ita, Sengers, Bram G., Garbis, Spiros D., Lewis, Rohan M.

“…ABSTRACT Intrahepatic cholestasis of pregnancy (ICP) causes increased transfer of maternal bile acids to the fetus and an increased incidence of sudden fetal…”
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Geometric constraint of mechanosensing by modification of hydrogel thickness prevents stiffness-induced differentiation in bone marrow stromal cells by Hernandez-Miranda, Maria L, Xu, Dichu, Ben Issa, Aya A, Johnston, David A, Browne, Martin, Cook, Richard B, Sengers, Bram G, Evans, Nicholas

“…Extracellular matrix (ECM) stiffness is fundamental in cell division, movement and differentiation. The stiffness that cells sense is determined not only by…”
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Glibenclamide transfer across the perfused human placenta is determined by albumin binding not transporter activity by Lofthouse, Emma M., Cleal, Jane K., Hudson, Georgina, Lewis, Rohan M., Sengers, Bram G.

“…The placenta mediates the transfer of maternal nutrients into the fetal circulation while removing fetal waste products, drugs and environmental toxins that…”
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Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach by Breuls, Roel G M, Sengers, Bram G, Oomens, Cees W J, Bouten, Carlijn V C, Baaijens, Frank P T

“…A multilevel finite element approach is applied to predict local cell deformations in engineered tissue constructs. Cell deformations are predicted from…”
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Depth profiling via nanoindentation for characterisation of the elastic modulus and hydraulic properties of thin hydrogel layers by Xu, Dichu, Hernandez Miranda, Maria Luisa, Evans, Nicholas D, Sengers, Bram G, Browne, Martin, Cook, Richard B

“…The accurate determination of the mechanical properties of hydrogels is of fundamental importance for a range of applications, including in assessing the…”
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Serial block‐face scanning electron microscopy reveals novel intercellular connections in human term placental microvasculature by Palaiologou, Eleni, Goggin, Patricia, Chatelet, David S., Ribeiro de Souza, Rodolfo, Chiu, Wendy, Ashley, Brogan, Lofthouse, Emma M., Sengers, Bram G., Torrens, Christopher, Page, Anton M., Cleal, Jane K., Lewis, Rohan M.

“…The placental microvasculature is a conduit for fetal blood allowing solute exchange between the mother and the fetus. Serial block‐face scanning electron…”
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Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux by Lofthouse, Emma M., Cleal, Jane K., O'Kelly, Ita M., Sengers, Bram G., Lewis, Rohan M.

“…Organic anion transporters (OATs) and organic anion transporting polypeptides (OATPs) are transport proteins that mediate exchange of metabolites, hormones and…”
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