Search Results - "Senger, Nicholas A."

Aromatic thiol-mediated cleavage of N–O bonds enables chemical ubiquitylation of folded proteins by Weller, Caroline E., Dhall, Abhinav, Ding, Feizhi, Linares, Edlaine, Whedon, Samuel D., Senger, Nicholas A., Tyson, Elizabeth L., Bagert, John D., Li, Xiaosong, Augusto, Ohara, Chatterjee, Champak

“…Access to protein substrates homogenously modified by ubiquitin (Ub) is critical for biophysical and biochemical investigations aimed at deconvoluting the…”
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Selenocysteine as a Latent Bioorthogonal Electrophilic Probe for Deubiquitylating Enzymes by Whedon, Samuel D, Markandeya, Nagula, Rana, Ambar S. J. B, Senger, Nicholas A, Weller, Caroline E, Tureček, Frantisek, Strieter, Eric R, Chatterjee, Champak

“…Deubiquitylating enzymes (DUBs) remove ubiquitin (Ub) from various cellular proteins and render eukaryotic ubiquitylation a dynamic process. The misregulation…”
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The Element Effect Revisited: Factors Determining Leaving Group Ability in Activated Nucleophilic Aromatic Substitution Reactions by Senger, Nicholas A, Bo, Bo, Cheng, Qian, Keeffe, James R, Gronert, Scott, Wu, Weiming

“…The “element effect” in nucleophilic aromatic substitution reactions (SNAr) is characterized by the leaving group order, F > NO2 > Cl ≈ Br > I, in activated…”
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Stabilities of uracil and pyridone-based carbanions: a systematic study in the gas phase and solution and implications for the mechanism of orotidine-5′-monophosphate decarboxylase by Senger, Nicholas A., Bliss, Carly E., Keeffe, James R., Gronert, Scott, Wu, Weiming

“…The stabilities of the C6-centered carbanions derived from 1,3-dimethyluracil, N-methyl-2-pyridone, and N-methyl-4-pyridone were systematically investigated in…”
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Improved synthesis of N1-substituted orotic acid derivatives by Senger, Nicholas A., Bowler, Jeannette T., Mercado, Rene S., Lin, Sidney, Wu, Weiming

“…An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to…”
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