Search Results - "Senger, Kate"

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins by Suryamohan, Kushal, Krishnankutty, Sajesh P., Guillory, Joseph, Jevit, Matthew, Schröder, Markus S., Wu, Meng, Kuriakose, Boney, Mathew, Oommen K., Perumal, Rajadurai C., Koludarov, Ivan, Goldstein, Leonard D., Senger, Kate, Dixon, Mandumpala Davis, Velayutham, Dinesh, Vargas, Derek, Chaudhuri, Subhra, Muraleedharan, Megha, Goel, Ridhi, Chen, Ying-Jiun J., Ratan, Aakrosh, Liu, Peter, Faherty, Brendan, de la Rosa, Guillermo, Shibata, Hiroki, Baca, Miriam, Sagolla, Meredith, Ziai, James, Wright, Gus A., Vucic, Domagoj, Mohan, Sangeetha, Antony, Aju, Stinson, Jeremy, Kirkpatrick, Donald S., Hannoush, Rami N., Durinck, Steffen, Modrusan, Zora, Stawiski, Eric W., Wiley, Kristen, Raudsepp, Terje, Kini, R. Manjunatha, Zachariah, Arun, Seshagiri, Somasekar

“…Snakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive…”
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Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations by Pahuja, Kanika Bajaj, Nguyen, Thong T., Jaiswal, Bijay S., Prabhash, Kumar, Thaker, Tarjani M., Senger, Kate, Chaudhuri, Subhra, Kljavin, Noelyn M., Antony, Aju, Phalke, Sameer, Kumar, Prasanna, Mravic, Marco, Stawiski, Eric W., Vargas, Derek, Durinck, Steffen, Gupta, Ravi, Khanna-Gupta, Arati, Trabucco, Sally E., Sokol, Ethan S., Hartmaier, Ryan J., Singh, Ashish, Chougule, Anuradha, Trivedi, Vaishakhi, Dutt, Amit, Patil, Vijay, Joshi, Amit, Noronha, Vanita, Ziai, James, Banavali, Sripad D., Ramprasad, Vedam, DeGrado, William F., Bueno, Raphael, Jura, Natalia, Seshagiri, Somasekar

“…Deregulated HER2 is a target of many approved cancer drugs. We analyzed 111,176 patient tumors and identified recurrent mutations in HER2 transmembrane domain…”
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Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer by Lin, WeiYu, Xu, Daqi, Austin, Cary D, Caplazi, Patrick, Senger, Kate, Sun, Yonglian, Jeet, Surinder, Young, Judy, Delarosa, Donnie, Suto, Eric, Huang, Zhiyu, Zhang, Juan, Yan, Donghong, Corzo, Cesar, Barck, Kai, Rajan, Sharmila, Looney, Carrie, Gandham, Vineela, Lesch, Justin, Liang, Wei-Ching, Mai, Elaine, Ngu, Hai, Ratti, Navneet, Chen, Yongmei, Misner, Dinah, Lin, Tori, Danilenko, Dimitry, Katavolos, Paula, Doudemont, Estelle, Uppal, Hirdesh, Eastham, Jeffrey, Mak, Judy, de Almeida, Patricia E, Bao, Katherine, Hadadianpour, Azadeh, Keir, Mary, Carano, Richard A D, Diehl, Lauri, Xu, Min, Wu, Yan, Weimer, Robby M, DeVoss, Jason, Lee, Wyne P, Balazs, Mercedesz, Walsh, Kevin, Alatsis, Kathila R, Martin, Flavius, Zarrin, Ali A

“…Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or…”
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation by Senger, Kate, Pham, Victoria C, Varfolomeev, Eugene, Hackney, Jason A, Corzo, Cesar A, Collier, Jenna, Lau, Vivian W C, Huang, Zhiyu, Hamidzhadeh, Kajal, Caplazi, Patrick, Peng, Ivan, Setiadi, A Francesca, Francis, Ross, Paler-Martinez, Andres, Kwon, Youngsu C, Ramirez-Carrozzi, Vladimir, Sun, Yonglian, Grigg, Patricia W, Roose-Girma, Merone, Jeet, Surinder, Barck, Kai H, Pham, Anna, Ota, Naruhisa, Ha, Connie, Stinson, Jeremy, Guillory, Joseph, Tam, Lucinda, Modrusan, Zora, Emson, Claire, McKenzie, Brent S, Townsend, Michael J, Carano, Richard A D, Warming, Søren, Vucic, Domagoj, DeVoss, Jason, Lee, Wyne P, Lill, Jennie R, Zarrin, Ali A

“…Tumor progression locus 2 (TPL2; also known as MAP3K8) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that phosphorylates the MAPK kinases…”
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GATA factors participate in tissue-specific immune responses in Drosophila larvae by Senger, K, Harris, K, Levine, M

“…Drosophila responds to infection by producing a broad range of antimicrobial agents in the fat body and more restricted responses in tissues such as the gut,…”
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DEAF-1 Regulates Immunity Gene Expression in Drosophila by Reed, Darien E., Huang, Xinhua M., Wohlschlegel, James A., Levine, Michael S., Senger, Kate

“…Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. Here, we present evidence that an additional regulatory factor,…”
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Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination by Misaghi, Shahram, Senger, Kate, Sai, Tao, Qu, Yan, Sun, Yonglian, Hamidzadeh, Kajal, Nguyen, Allen, Jin, Zhaoyu, Zhou, Meijuan, Yan, Donghong, Lin, Wei Yu, Lin, Zhonghua, Lorenzo, Maria N., Sebrell, Andrew, Ding, Jiabing, Xu, Min, Caplazi, Patrick, Austin, Cary D., Balazs, Mercedesz, Roose-Girma, Merone, DeForge, Laura, Warming, Søren, Lee, Wyne P., Dixit, Vishva M., Zarrin, Ali A.

“…Preceding antibody constant regions are switch (S) regions varying in length and repeat density that are targets of activation-induced cytidine deaminase. We…”
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Embryonic lethality and defective mammary gland development of activator‐function impaired conditional knock‐in Erbb3V943R mice by Senger, Kate, Yuan, Wenlin, Sagolla, Meredith, Doerr, Jonas, Bolon, Brad, Ziai, James, Sun, Kai‐Hui, Warming, Soren, Roose‐Girma, Merone, Zhang, Na, Tam, Lucinda, Newman, Robert J., Chaudhuri, Subhra, Antony, Aju, Goldstein, Leonard D., Durinck, Steffen, Jaiswal, Bijay S., Lafkas, Daniel, Modrusan, Zora, Seshagiri, Somasekar

“…ERBB3 is a pseudokinase domain‐containing member of the ERBB family of receptor tyrosine kinases (RTKs). Following ligand binding, ERBB receptors homo‐ or…”
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Mechanism by Which the IFN-β Enhanceosome Activates Transcription by Yie, Junming, Senger, Kate, Thanos, Dimitris

“…We demonstrate that in contrast to previous findings by using simple synthetic promoters or activators, the natural IFN-β enhanceosome activates transcription…”
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CtBP-Independent Repression in the Drosophila Embryo by Nibu, Yutaka, Senger, Kate, Levine, Michael

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA by Oh, Soyoung A, Senger, Kate, Madireddi, Shravan, Akhmetzyanova, Ilseyar, Ishizuka, Isabel E, Tarighat, Somayeh, Lo, Jerry H, Shaw, David, Haley, Benjamin, Rutz, Sascha

“…Genome engineering of T lymphocytes, the main effectors of antitumor adaptive immune responses, has the potential to uncover unique insights into their…”
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Computational Models for Neurogenic Gene Expression in the Drosophila Embryo by Zinzen, Robert P., Senger, Kate, Levine, Mike, Papatsenko, Dmitri

“…The early Drosophila embryo is emerging as a premiere model system for the computational analysis of gene regulation in development because most of the genes,…”
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Origin of Immunoglobulin Isotype Switching by Zhu, Catherine, Lee, Victor, Finn, Alyssa, Senger, Kate, Zarrin, Ali A., Du Pasquier, Louis, Hsu, Ellen

“…From humans to frogs, immunoglobulin class switching introduces different effector functions to antibodies through an intrachromosomal DNA recombination…”
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TPL2 kinase action and control of inflammation by Xu, Daqi, Kwon, Youngsu, Senger, Kate, Pham, Victoria, Varfolomeev, Eugene, Francis, George, Hackney, Jason, Parr, Brendan, Rathore, Nisha, Setiadi, Francesca, Boenig, Gladys, Harris, Seth, Lupardus, Patrick, Matsumoto, Marissa, Wang, Yuanyuan, Hanson, Jesse, Maher, Jonathan, Wu, Kai, Shaw, Andrey, Scherl, Alexis, Wu, Jiansheng, Lu, Cheng, Huang, Zhiyu, Zhang, Juan, Park, Summer, Sujatha-Bhaskar, Swathi, Almazan, Alice, Xu, Min, Caplazi, Patrick, Brightbill, Hans, Ghilardi, Nico, Townsend, Michael, Lee, Wyne, Johnson, Adam, McKenzie, Brent, Zarrin, Ali A, Wilson, Mark

“…Abstract Tumor progression locus 2 (TPL2; also known as MAP3K8) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that phosphorylates the MAPK…”
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Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response by Sun, Yonglian, Peng, Ivan, Webster, Joshua D, Suto, Eric, Lesch, Justin, Wu, Xiumin, Senger, Kate, Francis, George, Barrett, Kathy, Collier, Jenna L, Burch, Jason D, Zhou, Meijuan, Chen, Yuan, Chan, Connie, Eastham-Anderson, Jeff, Ngu, Hai, Li, Olga, Staton, Tracy, Havnar, Charles, Jaochico, Allan, Jackman, Janet, Jeet, Surinder, Riol-Blanco, Lorena, Wu, Lawren C, Choy, David F, Arron, Joseph R, McKenzie, Brent S, Ghilardi, Nico, Ismaili, Moulay Hicham Alaoui, Pei, Zhonghua, DeVoss, Jason, Austin, Cary D, Lee, Wyne P, Zarrin, Ali A

“…Interleukin-2 (IL-2)-inducible T cell kinase (ITK) mediates T cell receptor (TCR) signaling primarily to stimulate the production of cytokines, such as IL-4,…”
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Actionable activating oncogenic ERRB2/HER2 transmembrane and juxtamembrane domain mutations by Pahuja, Kanika Bajaj, Nguyen, Thong T., Jaiswal, Bijay S., Prabhash, Kumar, Thaker, Tarjani M., Senger, Kate, Chaudhuri, Subhra, Kljavin, Noelyn M., Antony, Aju, Phalke, Sameer, Kumar, Prasanna, Mravic, Marco, Stawiski, Eric W., Vargas, Derek, Durinck, Steffen, Gupta, Ravi, Khanna-Gupta, Arati, Trabucco, Sally E., Sokol, Ethan S., Hartmaier, Ryan J., Singh, Ashish, Chougule, Anuradha, Trivedi, Vaishakhi, Dutt, Amit, Patil, Vijay, Joshi, Amit, Noronha, Vanita, Ziai, James, Banavali, Sripad D, Ramprasad, Vedam, DeGrado, William F., Bueno, Raphael, Jura, Natalia, Seshagiri, Somasekar

“…Deregulated HER2 is a target of many approved cancer drugs. We analyzed 111,176 patient tumors and identified recurrent HER2 transmembrane domain (TMD) and…”
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PILRα negatively regulates mouse inflammatory arthritis by Sun, Yonglian, Caplazi, Patrick, Zhang, Juan, Mazloom, Anita, Kummerfeld, Sarah, Quinones, Gabriel, Senger, Kate, Lesch, Justin, Peng, Ivan, Sebrell, Andrew, Luk, Wilman, Lu, Yanmei, Lin, Zhonghua, Barck, Kai, Young, Judy, Del Rio, Mariela, Lehar, Sophie, Asghari, Vida, Lin, WeiYu, Mariathasan, Sanjeev, DeVoss, Jason, Misaghi, Shahram, Balazs, Mercedesz, Sai, Tao, Haley, Benjamin, Hass, Philip E, Xu, Min, Ouyang, Wenjun, Martin, Flavius, Lee, Wyne P, Zarrin, Ali A

“…Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we…”
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Transfection of ?(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells by Hiller, Kara M., Mayben, John P., Bendt, Katharine M., Manousos, George A., Senger, Kate, Cameron, H. Scott, Weston, Brent W.

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Sialylated ligands interact in cis to modulate PILRα inhibitory receptor in myeloid cells (P1358) by Sun, Yonglian, Senger, Kate, Sebrell, Andrew, Sai, Tao, Mazloom, Anita, Chinn, Yvonne, Luis, Elizabeth, Zarrin, Ali

“…Abstract Paired Ig-like type 2 receptor alpha (PILRα) is an inhibitory receptor expressed in myeloid cells. We show that an evolutionary conserved…”
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Evolutionarily Conserved Paired Immunoglobulin-like Receptor α (PILRα) Domain Mediates Its Interaction with Diverse Sialylated Ligands by Sun, Yonglian, Senger, Kate, Baginski, Tomasz K., Mazloom, Anita, Chinn, Yvonne, Pantua, Homer, Hamidzadeh, Kajal, Ramani, Sree Ranjani, Luis, Elizabeth, Tom, Irene, Sebrell, Andrew, Quinones, Gabriel, Ma, Yan, Mukhyala, Kiran, Sai, Tao, Ding, Jiabing, Haley, Benjamin, Shadnia, Hooman, Kapadia, Sharookh B., Gonzalez, Lino C., Hass, Philip E., Zarrin, Ali A.

“…Paired immunoglobulin-like receptor (PILR) α is an inhibitory receptor that recognizes several ligands, including mouse CD99, PILR-associating neural protein,…”
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