Search Results - "Senga, Takeshi"

Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells by Yoshihara, Masato, Yamakita, Yoshihiko, Kajiyama, Hiroaki, Senga, Takeshi, Koya, Yoshihiro, Yamashita, Mamoru, Nawa, Akihiro, Kikkawa, Fumitaka

“…Ovarian cancer cells shed from primary tumors can spread easily to the peritoneum via the peritoneal fluid. To allow further metastasis, the cancer cells must…”
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Nek2 as a novel molecular target for the treatment of breast carcinoma by Tsunoda, Nobuyuki, Kokuryo, Toshio, Oda, Koji, Senga, Takeshi, Yokoyama, Yukihiro, Nagino, Masato, Nimura, Yuji, Hamaguchi, Michinari

“…We investigated the role of Nek2, a member of the serine‐threonine kinase family, in the tumorigenic growth of breast carcinoma. Increased expression of Nek2…”
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S-Nitrosylation at Cysteine 498 of c-Src Tyrosine Kinase Regulates Nitric Oxide-mediated Cell Invasion by Rahman, Mohammad Aminur, Senga, Takeshi, Ito, Satoko, Hyodo, Toshinori, Hasegawa, Hitoki, Hamaguchi, Michinari

“…Nitric oxide (NO) plays a pivotal role in tumorigenesis, particularly with relation to cancer cell invasion and metastasis. NO can reversibly couple to…”
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Silencing of STRN4 suppresses the malignant characteristics of cancer cells by Wong, Meihong, Hyodo, Toshinori, Asano, Eri, Funasaka, Kohei, Miyahara, Ryoji, Hirooka, Yoshiki, Goto, Hidemi, Hamaguchi, Michinari, Senga, Takeshi

“…The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain‐containing proteins that associate with additional proteins to form a large…”
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Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin by Suzuki, Kazushi, Kokuryo, Toshio, Senga, Takeshi, Yokoyama, Yukihiro, Nagino, Masato, Hamaguchi, Michinari

“…Nek2 (NIMA‐related kinase 2) is involved in cell division and mitotic regulation by centrosome splitting. We previously reported that Nek2 depletion causes…”
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Phosphorylation of DEPDC1 at Ser110 is required to maintain centrosome organization during mitosis by Chen, Dan, Ito, Satoko, Hyodo, Toshinori, Asano-Inami, Eri, Yuan, Hong, Senga, Takeshi

“…DEPDC1 (DEP domain containing 1) is overexpressed in multiple cancers and is associated with cell cycle progression. In this report, we have investigated the…”
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KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear‑cell carcinoma cells by Kawai, Yosuke, Shibata, Kiyosumi, Sakata, Jun, Suzuki, Shiro, Utsumi, Fumi, Niimi, Kaoru, Sekiya, Ryuichiro, Senga, Takeshi, Kikkawa, Fumitaka, Kajiyama, Hiroaki

“…Kinesin family member 20A (KIF20A), which is involved in cytokinesis and intracellular transportation, has been recently reported to be upregulated in several…”
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SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling by Mansour, Mohammed A, Hyodo, Toshinori, Ito, Satoko, Kurita, Kenji, Kokuryo, Toshio, Uehara, Keisuke, Nagino, Masato, Takahashi, Masahide, Hamaguchi, Michinari, Senga, Takeshi

“…Special AT‐rich sequence binding protein 2 (SATB2) is an evolutionarily conserved transcription factor that has multiple roles in neuronal development,…”
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Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells by Sakata, Jun, Utsumi, Fumi, Suzuki, Shiro, Niimi, Kaoru, Yamamoto, Eiko, Shibata, Kiyosumi, Senga, Takeshi, Kikkawa, Fumitaka, Kajiyama, Hiroaki

“…ZEB1, a member of the zinc-finger E-box binding homeobox family, is considered to play a crucial role in cancer progression and metastasis. In the current…”
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Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells by Sugiyama, Kazuya, Kajiyama, Hiroaki, Shibata, Kiyosumi, Yuan, Hong, Kikkawa, Fumitaka, Senga, Takeshi

“…The TGFβ-mediated alteration of the tumor microenvironment plays a crucial role in tumor progression. Mesothelial cells are the primary components of the tumor…”
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Nek2 siRNA therapy using a portal venous port–catheter system for liver metastasis in pancreatic cancer by Kokuryo, Toshio, Hibino, Shigeru, Suzuki, Kazushi, Watanabe, Katsutaka, Yokoyama, Yukihiro, Nagino, Masato, Senga, Takeshi, Hamaguchi, Michinari

“…Nek2 (NIMA‐related kinase 2) is a serine‐threonine kinase and human homolog of the mitotic regulator NIMA of Aspergillus nidulan. We reported the efficiency of…”
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Misshapen-like kinase 1 (MINK1) Is a Novel Component of Striatin-interacting Phosphatase and Kinase (STRIPAK) and Is Required for the Completion of Cytokinesis by Hyodo, Toshinori, Ito, Satoko, Hasegawa, Hitoki, Asano, Eri, Maeda, Masao, Urano, Takeshi, Takahashi, Masahide, Hamaguchi, Michinari, Senga, Takeshi

“…Background: Cytokinesis is regulated by phosphorylation and dephosphorylation of proteins. Results: MINK1 associated with STRN4, a regulatory subunit of PP2A,…”
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A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1 by Hyodo, Toshinori, Ito, Satoko, Asano‐Inami, Eri, Chen, Dan, Senga, Takeshi

“…Dynamic changes in microtubule organization are regulated by numerous microtubule‐associating proteins and their post‐translational modification. Microtubule…”
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ALX1 Induces Snail Expression to Promote Epithelial-to-Mesenchymal Transition and Invasion of Ovarian Cancer Cells by HONG YUAN, KAJIYAMA, Hiroaki, KIKKAWA, Fumitaka, SENGA, Takeshi, ITO, Satoko, YOSHIKAWA, Nobuhisa, HYODO, Toshinori, ASANO, Eri, HASEGAWA, Hitoki, MAEDA, Masao, SHIBATA, Kiyosumi, HAMAGUCHI, Michinari

“…Ovarian cancer is a highly invasive and metastatic disease with a poor prognosis if diagnosed at an advanced stage, which is often the case. Recent studies…”
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ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility by Maeda, Masao, Hasegawa, Hitoki, Hyodo, Toshinori, Ito, Satoko, Asano, Eri, Yuang, Hong, Funasaka, Kohei, Shimokata, Kaoru, Hasegawa, Yoshinori, Hamaguchi, Michinari, Senga, Takeshi

“…Rho GTPases are molecular switches that transmit biochemical signals in response to extracellular stimuli to elicit changes in the actin cytoskeleton. Rho…”
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PCNA Is a Cofactor for Cdt1 Degradation by CUL4/DDB1-mediated N-terminal Ubiquitination by Senga, Takeshi, Sivaprasad, Umasundari, Zhu, Wenge, Park, Jong Hoon, Arias, Emily E., Walter, Johannes C., Dutta, Anindya

“…Cdt1, a protein essential in G1 for licensing of origins for DNA replication, is inhibited in S-phase, both by binding to geminin and degradation by…”
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SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer by Mansour, Mohammed A, Hyodo, Toshinori, Akter, Khondker Ayesha, Kokuryo, Toshio, Uehara, Keisuke, Nagino, Masato, Senga, Takeshi

“…Special AT-rich sequence-binding protein 1 and 2 (SATB1/2) are nuclear matrix-associated proteins involved in chromatin remodeling and regulation of gene…”
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Arginine methylation of ubiquitin‐associated protein 2‐like is required for the accurate distribution of chromosomes by Maeda, Masao, Hasegawa, Hitoki, Sugiyama, Mai, Hyodo, Toshinori, Ito, Satoko, Chen, Dan, Asano, Eri, Masuda, Akio, Hasegawa, Yoshinori, Hamaguchi, Michinari, Senga, Takeshi

“…ABSTRACT Proper bioriented attachment of microtubules and kinetochores is essential for the precise distribution of duplicated chromosomes to each daughter…”
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Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy by Nagasaka, Yosuke, Kaneko, Hiroki, Ye, Fuxiang, Kachi, Shu, Asami, Tetsu, Kato, Seiichi, Takayama, Kei, Hwang, Shiang-Jyi, Kataoka, Keiko, Shimizu, Hideyuki, Iwase, Takeshi, Funahashi, Yasuhito, Higuchi, Akiko, Senga, Takeshi, Terasaki, Hiroko

“…Proliferative vitreoretinopathy (PVR) is one of the most severe ocular diseases. Fibrotic changes in retinal cells are considered to be involved in the…”
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SHCBP1 is required for midbody organization and cytokinesis completion by Asano, Eri, Hasegawa, Hitoki, Hyodo, Toshinori, Ito, Satoko, Maeda, Masao, Chen, Dan, Takahashi, Masahide, Hamaguchi, Michinari, Senga, Takeshi

“…The centralspindlin complex, which is composed of MKLP1 and MgcRacGAP, is one of the crucial factors involved in cytokinesis initiation. Centralspindlin is…”
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