Search Results - "Seng, Wu Yuan"
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1
Microplastic sources, formation, toxicity and remediation: a review
Published in Environmental chemistry letters (01-08-2023)“…Microplastic pollution is becoming a major issue for human health due to the recent discovery of microplastics in most ecosystems. Here, we review the sources,…”
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2
Anticancer Activities of Surfactin and Potential Application of Nanotechnology Assisted Surfactin Delivery
Published in Frontiers in pharmacology (26-10-2017)“…Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types,…”
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3
Biological Activities of Paeonol in Cardiovascular Diseases: A Review
Published in Molecules (Basel, Switzerland) (17-08-2021)“…Paeonol is a naturally existing bioactive compound found in the root bark of and it is traditionally used in Chinese medicine for the prevention and management…”
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4
Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
Published in Molecules (Basel, Switzerland) (20-01-2023)“…Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed and developing countries. According to the WHO report, the morbidity…”
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The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review
Published in ACS omega (06-02-2024)“…Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the environment and human health. This review is aimed at…”
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6
SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis
Published in Journal of personalized medicine (31-01-2023)“…is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous…”
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7
Comparison of Nutritional Knowledge, Attitudes and Practices between Urban and Rural Secondary School Students: A Cross-Sectional Study in Sabah, East Malaysia
Published in Foods (30-08-2021)“…Nutritional knowledge, attitudes and practice (KAP) may guide healthy meal choices. Here, nutritional KAP was compared across school students in Sabah based on…”
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Molecular Mechanisms of Antiviral Agents against Dengue Virus
Published in Viruses (01-03-2023)“…Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine…”
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A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
Published in Frontiers in pharmacology (25-03-2022)“…Linn. ( ), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many…”
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10
Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery
Published in Pharmacological reports (01-12-2022)“…The global pandemic of COVID-19 is a serious public health concern. Over 625 million confirmed cases and more than 6 million deaths have been recorded…”
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11
Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells
Published in Biochimica et biophysica acta. General subjects (01-02-2017)“…We previously showed that pancreatic stellate cells (PSC) secreted interleukin (IL)-6 and promoted pancreatic ductal adenocarcinoma (PDAC) cell proliferation…”
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12
Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase
Published in Journal of biomolecular structure & dynamics (02-09-2023)“…Diabetes mellitus (DM) is a global chronic disease characterized by hyperglycemia and insulin resistance. The unsavory severe gastrointestinal side-effects of…”
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13
Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy
Published in Toxicology reports (01-01-2021)“…•Chronic intake of alcohol initiates a pathogenic process that involves the production of protein-aldehyde adducts, and release of cytokines.•Involved gene…”
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14
A review on cytomegalovirus in patients with autoimmune inflammatory rheumatic diseases: Prevalence, clinical spectrum, treatment, and antiviral prophylaxis
Published in Proceedings of Singapore Healthcare (01-03-2024)“…Human cytomegalovirus (CMV) is a highly infectious virus that is prevalent among adults worldwide. In immunocompetent individuals, CMV infection rarely causes…”
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15
Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy
Published in Molecules (Basel, Switzerland) (01-08-2022)“…Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial…”
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Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment
Published in Molecules (Basel, Switzerland) (01-01-2022)“…Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the…”
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17
Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer
Published in Acta pharmaceutica Sinica. B (01-03-2020)“…Activated pancreatic stellate cells (PSCs) have been widely accepted as a key precursor of excessive pancreatic fibrosis, which is a crucial hallmark of…”
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18
Anti- COVID-19 drug discovery by flavonoid derivatives: an extensive computational drug design approach
Published in Cellular and Molecular Biology (08-09-2024)“…The present study deals with the in-silico analyses of several flavonoid derivatives to explore COVID-19 through pharmacophore modelling, molecular docking,…”
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Kirenol: A Potential Natural Lead Molecule for a New Drug Design, Development, and Therapy for Inflammation
Published in Molecules (Basel, Switzerland) (23-01-2022)“…Kirenol, a potential natural diterpenoid molecule, is mainly found in species. Kirenol has received a lot of interest in recent years due to its wide range of…”
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Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders
Published in Molecules (Basel, Switzerland) (20-01-2022)“…Cardiovascular disorders (CVDs) are the leading risk factor for death worldwide, and research into the processes and treatment regimens has received a lot of…”
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