Recurrent Hepatocellular Carcinoma After Liver Transplantation: Analysis of Risk Factors

Abstract Background Survival after orthotopic liver transplantation (LT) for hepatocellular carcinoma (HCC) is influenced by tumor recurrence. This study examines the survival of patients who underwent LT for HCC and developed recurrence of tumor after transplantation. Methods A retrospective analys...

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Bibliographic Details
Published in:	Transplantation proceedings Vol. 48; no. 9; pp. 2990 - 2993
Main Authors:	Perea del Pozo, E, Bernal Bellido, C, Sendín Matín, M, Cepeda Franco, C, Álamo Martínez, J.M, Suarez Artacho, G, Marín Gómez, L.M, Padillo Ruiz, J, Gomez Bravo, M.Á
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2016
Subjects:	Adult Aged Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Female Humans Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local - etiology Neoplasm Recurrence, Local - surgery Retrospective Studies Risk Factors Surgery
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Summary:	Abstract Background Survival after orthotopic liver transplantation (LT) for hepatocellular carcinoma (HCC) is influenced by tumor recurrence. This study examines the survival of patients who underwent LT for HCC and developed recurrence of tumor after transplantation. Methods A retrospective analysis was performed of the 200 patients who underwent LT secondary to HCC from 1990 to 2014. We excluded 19 patients from the study owing to early postoperative deaths in the 1st month. We divided our sample into 2 groups according to the presence of recurrence. We performed a univariate analysis to identify variables that are significantly associated with the risk of recurrence. Afterward we use multivariate analysis regression analysis to find independent significance. Results Univariate analysis shows significant relationship between high Edmondson-Steiner grades (G3-G4) and the development of tumor recurrence. Tumor size, vascular invasion, and capsular invasion were found to be independent risk factors of tumor recurrence in the multivariate analysis. Conclusions Tumor recurrence defines survival of patients who underwent LT for HCC. In this study we discuss which histologic factor are associated with higher risk of tumor recurrence, and therefore a negative the impact on patient's survival.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2016.09.020