Search Results - "Senavova, Jana"
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Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma
Published in Experimental hematology & oncology (01-11-2024)“…The phosphatidylinositol 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway is critically active in many cell types, both normal and neoplastic. Many…”
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Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion
Published in Experimental hematology & oncology (25-03-2024)“…Mantle cell lymphoma (MCL) is a chronically relapsing malignancy with deregulated cell cycle progression. We analyzed efficacy, mode of action, and predictive…”
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P1240: MICROBIOME DIVERSITY IN PATIENTS WITH LYMPHOMA
Published in HemaSphere (08-08-2023)Get full text
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Combinatorial PI3K/AKT Pathway Inhibition As a Therapeutic Approach in Diffuse Large B-Cell Lymphoma
Published in Blood (15-11-2022)Get full text
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Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies
Published in Blood advances (22-10-2024)“…•PIK3CA gain and PTEN loss decrease the dependence of MCL cells on BCR signaling and antiapoptotic BCL2.•PIK3CA gain and PTEN loss lead to complex metabolic…”
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Internal comorbidities and complications of multiple sclerosis therapy - don't be caught off guard
Published in Vnitřní lékar̆stvĭ (01-10-2023)“…Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, mainly affecting young adults. Factors positively influencing its course…”
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