Search Results - "Senaratne, Ryan"

Attenuation of Mycobacterium tuberculosis Functionally Disrupted in a Fatty Acyl-Coenzyme A Synthetase Gene fadD5 by Dunphy, Kathleen Y., Senaratne, Ryan H., Masuzawa, Mamiko, Kendall, Lon V., Riley, Lee W.

“…One key adaptation that Mycobacterium tuberculosis established to survive long term in vivo is a reliance on lipids as an energy source. M. tuberculosis H37Rv…”
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Inhibition of toll‐like receptor 2 (TLR‐2)‐mediated response in human alveolar epithelial cells by mycolic acids and Mycobacterium tuberculosis mce1 operon mutant by Sequeira, Patricia C., Senaratne, Ryan H., Riley, Lee W.

“…In human lungs, the earliest encounter of Mycobacterium tuberculosis, the agent of tuberculosis, involves alveolar epithelial cells. Droplets expectorated by a…”
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Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice by Senaratne, Ryan H, Sidders, Ben, Sequeira, Patricia, Saunders, Grainne, Dunphy, Kathleen, Marjanovic, Olivera, Reader, J. Rachel, Lima, Patricia, Chan, Stephen, Kendall, Sharon, McFadden, Johnjoe, Riley, Lee W

“…1 School of Public Health, University of California, Berkeley, CA 94720, USA 2 School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2…”
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5′‐Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice by Senaratne, Ryan H., De Silva, A. Dharshan, Williams, Spencer J., Mougous, Joseph D., Reader, J. Rachel, Zhang, Tianjiao, Chan, Stephen, Sidders, Ben, Lee, Dong H., Chan, John, Bertozzi, Carolyn R., Riley, Lee W.

“…Summary A major obstacle to tuberculosis (TB) control is the problem of chronic TB infection (CTBI). Here we report that 5′‐adenosinephosphosulphate reductase…”
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Trehalose Is Required for Growth of Mycobacterium smegmatis by Woodruff, Peter J, Carlson, Brian L, Siridechadilok, Bunpote, Pratt, Matthew R, Senaratne, Ryan H, Mougous, Joseph D, Riley, Lee W, Williams, Spencer J, Bertozzi, Carolyn R

“…Mycobacteria contain high levels of the disaccharide trehalose in free form as well as within various immunologically relevant glycolipids such as cord factor…”
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Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria by Kiemer, Alexandra K., Senaratne, Ryan H., Hoppstädter, Jessica, Diesel, Britta, Riley, Lee W., Tabeta, Koichi, Bauer, Stefan, Beutler, Bruce, Zuraw, Bruce L.

“…Alveolar macrophages are the first line of host defence against mycobacteria, but an insufficient host response allows survival of bacteria within macrophages…”
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Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis by Bertozzi, Carolyn R, Mougous, Joseph D, Petzold, Christopher J, Senaratne, Ryan H, Lee, Dong H, Akey, David L, Lin, Fiona L, Munchel, Sarah E, Pratt, Matthew R, Riley, Lee W, Leary, Julie A, Berger, James M

“…Sulfolipid-1 (SL-1) is an abundant sulfated glycolipid and potential virulence factor found in Mycobacterium tuberculosis. SL-1 consists of a…”
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5′-Adenosinephosphosulfate Lies at a Metabolic Branch Point in Mycobacteria by Williams, Spencer J., Senaratne, Ryan H., Mougous, Joseph D., Riley, Lee W., Bertozzi, Carolyn R.

“…Bacterial sulfate assimilation pathways provide for activation of inorganic sulfur for the biosynthesis of cysteine and methionine, through either adenosine…”
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A Sulfated Metabolite Produced by stf3 Negatively Regulates the Virulence of Mycobacterium tuberculosis by Mougous, Joseph D., Senaratne, Ryan H., Petzold, Christopher J., Jain, Madhulika, Lee, Dong H., Schelle, Michael W., Leavell, Michael D., Cox, Jeffery S., Leary, Julie A., Riley, Lee W., Bertozzi, Carolyn R.

“…Sulfated molecules have been shown to modulate isotypic interactions between cells of metazoans and heterotypic interactions between bacterial pathogens or…”
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Inhibition of toll-like receptor 2 (TLR-2)-mediated response in human alveolar epithelial cells by mycolic acids and Mycobacterium tuberculosismce1 operon mutant by Sequeira, Patricia C., Senaratne, Ryan H., Riley, Lee W.

“…Abstract In human lungs, the earliest encounter of Mycobacterium tuberculosis, the agent of tuberculosis, involves alveolar epithelial cells. Droplets…”
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Discovery of Sulfated Metabolites in Mycobacteria with a Genetic and Mass Spectrometric Approach by Mougous, Joseph D., Leavell, Michael D., Senaratne, Ryan H., Leigh, Clifton D., Williams, Spencer J., Riley, Lee W., Leary, Julie A., Bertozzi, Carolyn R.

“…The study of the metabolome presents numerous challenges, first among them being the cataloging of its constituents. A step in this direction will be the…”
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Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity by Raynaud, Catherine, Laneelle, Marie-Antoinette, Senaratne, Ryan H, Draper, Philip, Laneelle, Gilbert, Daffe, Mamadou

“…1 Institut de Pharmacologie et de Biologie Structurale du Centre National de la Recherche Scientifique and Université Paul Sabatier, 205 route de Narbonne,…”
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Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant by Senaratne, Ryan H, Mougous, Joseph D, Reader, J. Rachel, Williams, Spencer J, Zhang, Tianjiao, Bertozzi, Carolyn R, Riley, Lee W

“…1 School of Public Health, University of California, Berkeley, CA 94720, USA 2 Department of Chemistry, University of California, Berkeley, CA 94720, USA 3…”
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Expression of a gene for a porin-like protein of the OmpA family from Mycobacterium tuberculosis H37Rv by Senaratne, R H, Mobasheri, H, Papavinasasundaram, K G, Jenner, P, Lea, E J, Draper, P

“…An open reading frame in the genomic database of Mycobacterium tuberculosis H37Rv was identified as having homology with an outer membrane protein. We found…”
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Posttreatment Reactivation of Tuberculosis in Mice Caused by Mycobacterium tuberculosis Disrupted in mce1R by Cheigh, Chan-Ick, Senaratne, Ryan, Uchida, Yujiro, Casali, Nicola, Kendall, Lon V., Riley, Lee W.

“…Background. The reactivation of tuberculosis arises in persons who are latently infected and in those who have been previously treated. The mechanism of the…”
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Post-treatment reactivation tuberculosis in mice caused by Mycobacterium tuberculosis disrupted in mce1R by Cheigh, Chan-Ick, Senaratne, Ryan, Uchida, Yujiro, Casali, Nicola, Kendall, Lon V., Riley, Lee W.

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Attenuation of Mycobacterium tuberculosis functionally disrupted in a fatty acyl-CoA synthetase gene fadD5 by Dunphy, Kathleen Y., Senaratne, Ryan H., Masuzawa, Mamiko, Kendall, Lon V., Riley, Lee W.

“…One key adaptation that Mycobacterium tuberculosis established to survive long term in vivo is a reliance on lipids as an energy source. M. tuberculosis H37Rv…”
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Attenuation of Mycobacterium tuberculosis FunctionaHy Disrupted in a Fatly Acyl-Coenzyme A Synthetase Gene fadD5 by Dunphy, Kathleen Y., Senaratne, Ryan H., Masuzawa, Mamiko, Kendall, Lon V., Riley, Lee W.

“…One key adaptation that Mycobacterium tuberculosis established to survive long term in vivo is a reliance on lipids as an energy source. M. tuberculosis H37Rv…”
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Enhanced mortality despite control of lung infection in mice aerogenically infected with a Mycobacterium tuberculosis mce1 operon mutant by Lima, Patricia, Sidders, Ben, Morici, Lisa, Reader, Rachel, Senaratne, Ryan, Casali, Nicola, Riley, Lee W.

“…Mycobacterium tuberculosis causes a variety of host clinical outcomes. We previously showed that M. tuberculosis disrupted in an operon called mce1…”
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Enhanced mortality despite control of lung infection in mice aerogenically infected with a Mycobacterium tuberculosis mcel operon mutant by LIMA, Patricia, SIDDERS, Ben, MORICI, Lisa, READER, Rachel, SENARATNE, Ryan, CASALI, Nicola, RILEY, Lee W

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