Search Results - "Sena de Oliveira, Aldo"
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Tribute to Professor Anton Joseph Hopfinger: Contributions to the Study of Structure-activity Relationships
Published in Current topics in medicinal chemistry (01-01-2021)Get more information
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Structure‐Metabolism Relationships of Benzimidazole Derivatives with anti‐Trypanosoma cruzi Activity for Chagas Disease
Published in ChemMedChem (16-10-2024)“…This study introduces further insights from the hit‐to‐lead optimization process involving a series of benzimidazole derivatives acting as inhibitors of the…”
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Cell Cycle Arrest and Apoptosis Induction by a New 2,4-Dinitrobenzenesulfonamide Derivative In Acute Leukemia Cells
Published in Journal of pharmacy & pharmaceutical sciences (2021)“…Current therapies for acute leukemias (ALs) are associated with severe adverse reactions and high relapse rates, which makes the search for new antileukemic…”
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Phomoxanthone A, Compound of Endophytic Fungi Paecilomyces sp. and Its Potential Antimicrobial and Antiparasitic
Published in Antibiotics (Basel) (29-09-2022)“…The present work reports the isolation and biological evaluation of three dimeric xanthones from Paecilomyces sp. EJC01.1 isolated as endophytic from Schnella…”
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Treatment of Alzheimer's Disease: Contemporary Perspectives in Medicinal Chemistry
Published in Current medicinal chemistry (01-01-2023)Get more information
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DYRK1A Inhibitors and Perspectives for the Treatment of Alzheimer's Disease
Published in Current medicinal chemistry (01-01-2023)“…Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most common form of dementia, especially in the elderly. Due to the increase in life…”
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Witches, potions, and metabolites: an overview from a medicinal perspective
Published in RSC medicinal chemistry (20-04-2022)“…Witches were popularly imagined as older women (above middle age), with large warty noses, whose clothes were shabby and used pointy hats. They are usually…”
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Carajurin Induces Apoptosis in Leishmania amazonensis Promastigotes through Reactive Oxygen Species Production and Mitochondrial Dysfunction
Published in Pharmaceuticals (Basel, Switzerland) (09-03-2022)“…Carajurin is the main constituent of species with reported anti- activity. However, its mechanism of action has not been described. This study investigated the…”
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Structure-activity relationships of sulfonamides derived from carvacrol and their potential for the treatment of Alzheimer's disease
Published in RSC medicinal chemistry (01-02-2020)“…Five synthetic sulfonamides derived from carvacrol, a natural product and a small molecule with druglike properties, were evaluated with respect to their…”
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Monomethylsulochrin isolated from biomass extract of Aspergillus sp. against Leishmania amazonensis: In vitro biological evaluation and molecular docking
Published in Frontiers in cellular and infection microbiology (25-08-2022)“…Leishmaniasis represents a serious world health problem, with 1 billion people being exposed to infection and a broad spectrum of clinical manifestations with…”
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Structure-activity relationships of novel N -imidazoylpiperazines with potent anti- Trypanosoma cruzi activity
Published in Future medicinal chemistry (01-02-2024)“…Chagas disease is caused by the parasite , and the lack of effective and safe treatments makes identifying new classes of compounds with anti- activity of…”
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Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines
Published in Bioorganic chemistry (01-11-2021)“…[Display omitted] •The chalcones F07, F09 and F10 were strongly cytotoxic to AML (K562) and ALL (Jurkat) cell lines.•F07, F09 and F10 were not cytotoxic to…”
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Phomoxanthone A, Compound of Endophytic Fungi IPaecilomyces/I sp. and Its Potential Antimicrobial and Antiparasitic
Published in Antibiotics (Basel) (01-09-2022)“…The present work reports the isolation and biological evaluation of three dimeric xanthones from Paecilomyces sp. EJC01.1 isolated as endophytic from Schnella…”
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JOGO NO SCRATCH COMO OBJETO DE APRENDIZAGEM PARA A PROMOÇÃO DA ALFABETIZAÇÃO CIENTÍFICA E TECNOLÓGICA
Published in Revista Brasileira de Ensino de Ciências e Matemática (23-02-2022)“…Este artigo, analisa a contribuição do Objeto de Aprendizagem (OA) tipo jogo, desenvolvido no Scratch, como ferramenta pedagógica na promoção da Alfabetização…”
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A QUÍMICA, O IMAGINÁRIO E AS CRIANÇAS: notas sobre o currículo pós-moderno
Published in InterEspaço (24-01-2018)“…CHEMISTRY, IMAGINARY AND CHILDREN: notes on the post-modern curriculumLA QUÍMICA, EL IMAGINARIO Y LOS NIÑOS: notas sobre el currículo pós-modernoA elaboração…”
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