Search Results - "Sen, George"

Regulation of integrin and extracellular matrix genes by HNRNPL is necessary for epidermal renewal by Li, Jingting, Chen, Yifang, Tiwari, Manisha, Bansal, Varun, Sen, George L

“…Stratified epithelia such as the epidermis require coordinated regulation of stem and progenitor cell proliferation, survival, and differentiation to maintain…”
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DDX6 Orchestrates Mammalian Progenitor Function through the mRNA Degradation and Translation Pathways by Wang, Ying, Arribas-Layton, Marc, Chen, Yifang, Lykke-Andersen, Jens, Sen, George L.

“…In adult tissues, stem and progenitor cells must balance proliferation and differentiation to maintain homeostasis. How this is done is unclear. Here, we show…”
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Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury by Zhang, Ling-juan, Sen, George L., Ward, Nicole L., Johnston, Andrew, Chun, Kimberly, Chen, Yifang, Adase, Christopher, Sanford, James A., Gao, Nina, Chensee, Melanie, Sato, Emi, Fritz, Yi, Baliwag, Jaymie, Williams, Michael R., Hata, Tissa, Gallo, Richard L.

“…Type 1 interferons (IFNs) promote inflammation in the skin but the mechanisms responsible for inducing these cytokines are not well understood. We found that…”
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DNMT1 maintains progenitor function in self-renewing somatic tissue by Khavari, Paul A, Sen, George L, Reuter, Jason A, Webster, Daniel E, Zhu, Lilly

“…Progenitor cells maintain self-renewing tissues throughout life by sustaining their capacity for proliferation while suppressing cell cycle exit and terminal…”
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TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation by Li, Jingting, Tiwari, Manisha, Xu, Xiaojun, Chen, Yifang, Tamayo, Pablo, Sen, George L.

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Progenitor Function in Self-Renewing Human Epidermis is Maintained by the Exosome by Mistry, Devendra S., Chen, Yifang, Sen, George L.

“…Stem and progenitor cells maintain the tissue they reside in for life by regulating the balance between proliferation and differentiation. How this is done is…”
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ZNF750 Is a p63 Target Gene that Induces KLF4 to Drive Terminal Epidermal Differentiation by Sen, George L., Boxer, Lisa D., Webster, Dan E., Bussat, Rose T., Qu, Kun, Zarnegar, Brian J., Johnston, Danielle, Siprashvili, Zurab, Khavari, Paul A.

“…Disrupted epidermal differentiation characterizes numerous diseases that impact >25% of the population. In a search for dominant mediators of differentiation,…”
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RACK1 Prevents the Premature Differentiation of Epidermal Progenitor Cells by Inhibiting IRF6 Expression by Ling, Ji, Tiwari, Manisha, Chen, Yifang, Sen, George L.

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BRD4 Is Necessary for Differentiation Downstream of Epidermal Lineage-Determining Transcription Factors by Jones, Jackson, Chen, Yifang, Tiwari, Manisha, Li, Jingting, Ling, Ji, Sen, George L.

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CDK12 Is Necessary to Promote Epidermal Differentiation Through Transcription Elongation by Li, Jingting, Tiwari, Manisha, Chen, Yifang, Luanpitpong, Sudjit, Sen, George L

“…Proper differentiation of the epidermis is essential to prevent water loss and to protect the body from the outside environment. Perturbations in this process…”
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ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes by Li, Jingting, Bansal, Varun, Tiwari, Manisha, Chen, Yifang, Sen, George L.

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The Switch/Sucrose Nonfermentable Subunit ARID1A Mediates Neutrophil-Associated Skin Inflammatory Responses by Batzorig, Uyanga, Chen, Yifang, Liu, Ye, Fernández-Méndez, Celia, Mahapatra, Samiksha, Lim, Sung Ha, Hong, Seung-Phil, Sen, George L

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Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies by Blau, Helen M, Sen, George L

“…RNA interference (RNAi) is an important means of eliminating mRNAs, but the intracellular location of RNA-induced silencing complex (RISC) remains unknown. We…”
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RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia by Ling, Ji, Sckaff, Maria, Tiwari, Manisha, Chen, Yifang, Li, Jingting, Jones, Jackson, Sen, George L

“…Proper epithelial development and homeostasis depends on strict control of oriented cell division. Current evidence shows that this process is regulated by…”
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Post-Transcriptional Mechanisms Regulating Epidermal Stem and Progenitor Cell Self-Renewal and Differentiation by Li, Jingting, Sen, George L.

“…Epidermal stem and progenitor cells exist within the basal layer of the epidermis and serve to replenish the loss of differentiated cells because of normal…”
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SNAI2 Controls the Undifferentiated State of Human Epidermal Progenitor Cells by Mistry, Devendra S., Chen, Yifang, Wang, Ying, Zhang, Kang, Sen, George L.

“…The transcription factor, SNAI2, is an inducer of the epithelial to mesenchymal transition (EMT) which mediates cell migration during development and tumor…”
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HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs by Li, Jingting, Chen, Yifang, Xu, Xiaojun, Jones, Jackson, Tiwari, Manisha, Ling, Ji, Wang, Ying, Harismendy, Olivier, Sen, George L.

“…Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms…”
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The transcription regulators ZNF750 and LSD1/KDM1A dampen inflammation on the skin's surface by silencing pattern recognition receptors by Liu, Ye, Chen, Yifang, Batzorig, Uyanga, Li, Jingting, Fernández-Méndez, Celia, Mahapatra, Samiksha, Li, Fengwu, Sam, Shebin, Dokoshi, Tatsuya, Hong, Seung-Phil, Nakatsuji, Teruaki, Gallo, Richard L, Sen, George L

“…The surface of the skin is continually exposed to pro-inflammatory stimuli; however, it is unclear why it is not constantly inflamed due to this exposure…”
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Cellular toxicity of silicon carbide nanomaterials as a function of morphology by Chen, Fang, Li, Gongyi, Zhao, Eric Ruike, Li, Jingting, Hableel, Ghanim, Lemaster, Jeanne E., Bai, Yuting, Sen, George L., Jokerst, Jesse V.

“…Silicon carbide has been shown to be biocompatible and is used as a coating material for implanted medical devices to prevent biofilms. Silicon carbide…”
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brief history of RNAi: the silence of the genes by Sen, George L, Blau, Helen M

“…The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable…”
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