Search Results - "Sen, Arko"

Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma by Sen, Arko, Huo, Yuchen, Elster, Jennifer, Zage, Peter E, McVicker, Graham

“…Neuroblastoma is a pediatric malignancy with a high frequency of metastatic disease at initial diagnosis. Neuroblastoma tumors have few recurrent…”
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Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma by Sen, Arko, Prager, Briana C, Zhong, Cuiqing, Park, Donglim, Zhu, Zhe, Gimple, Ryan C, Wu, Qiulian, Bernatchez, Jean A, Beck, Sungjun, Clark, Alex E, Siqueira-Neto, Jair L, Rich, Jeremy N, McVicker, Graham

“…Glioblastoma is the most prevalent primary malignant brain tumor in adults and is characterized by poor prognosis and universal tumor recurrence. Effective…”
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Early life lead exposure causes gender-specific changes in the DNA methylation profile of DNA extracted from dried blood spots by Sen, Arko, Heredia, Nicole, Senut, Marie-Claude, Hess, Matthew, Land, Susan, Qu, Wen, Hollacher, Kurt, Dereski, Mary O, Ruden, Douglas M

“…In this paper, we tested the hypothesis that early life lead (Pb) exposure associated DNA methylation (5 mC) changes are dependent on the sex of the child and…”
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Epigenetics of early-life lead exposure and effects on brain development by Senut, Marie-Claude, Cingolani, Pablo, Sen, Arko, Kruger, Adele, Shaik, Asra, Hirsch, Helmut, Suhr, Steven T, Ruden, Douglas

“…The epigenetic machinery plays a pivotal role in the control of many of the body's key cellular functions. It modulates an array of pliable mechanisms that are…”
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Size-Dependent Toxicity of Gold Nanoparticles on Human Embryonic Stem Cells and Their Neural Derivatives by Senut, Marie-Claude, Zhang, Yanhua, Liu, Fangchao, Sen, Arko, Ruden, Douglas M., Mao, Guangzhao

“…This study explores the use of human embryonic stem cells (hESCs) for assessing nanotoxicology, specifically, the effect of gold nanoparticles (AuNPs) of…”
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Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren by Sen, Arko, Heredia, Nicole, Senut, Marie-Claude, Land, Susan, Hollocher, Kurt, Lu, Xiangyi, Dereski, Mary O., Ruden, Douglas M.

“…We report that the DNA methylation profile of a child’s neonatal whole blood can be significantly influenced by his or her mother’s neonatal blood lead levels…”
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Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation by Senut, Marie-Claude, Sen, Arko, Cingolani, Pablo, Shaik, Asra, Land, Susan J., Ruden, Douglas M.

“…Exposure to lead (Pb) during childhood can result in learning disabilities and behavioral problems. Although described in animal models, whether Pb exposure…”
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Discovering single nucleotide variants and indels from bulk and single-cell ATAC-seq by Massarat, Arya R, Sen, Arko, Jaureguy, Jeff, Tyndale, Sélène T, Fu, Yi, Erikson, Galina, McVicker, Graham

“…Abstract Genetic variants and de novo mutations in regulatory regions of the genome are typically discovered by whole-genome sequencing (WGS), however WGS is…”
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Deletion mapping of regulatory elements for GATA3 in T cells reveals a distal enhancer involved in allergic diseases by Chen, Hsiuyi V., Lorenzini, Michael H., Lavalle, Shanna N., Sajeev, Karthyayani, Fonseca, Ariana, Fiaux, Patrick C., Sen, Arko, Luthra, Ishika, Ho, Aaron J., Chen, Aaron R., Guruvayurappan, Karthik, O’Connor, Carolyn, McVicker, Graham

“…GATA3 is essential for T cell differentiation and is surrounded by genome-wide association study (GWAS) hits for immune traits. Interpretation of these GWAS…”
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Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood by Sen, Arko, Cingolani, Pablo, Senut, Marie-Claude, Land, Susan, Mercado-Garcia, Adriana, Tellez-Rojo, Martha M, Baccarelli, Andrea A, Wright, Robert O, Ruden, Douglas M

“…Prenatal exposure to neurotoxicants such as lead (Pb) may cause stable changes in the DNA methylation (5mC) profile of the fetal genome. However, few studies…”
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Smooth, an hnRNP-L Homolog, Might Decrease Mitochondrial Metabolism by Post-Transcriptional Regulation of Isocitrate Dehydrogenase (Idh) and Other Metabolic Genes in the Sub-Acute Phase of Traumatic Brain Injury by Sen, Arko, Gurdziel, Katherine, Liu, Jenney, Qu, Wen, Nuga, Oluwademi O, Burl, Rayanne B, Hüttemann, Maik, Pique-Regi, Roger, Ruden, Douglas M

“…Traumatic brain injury (TBI) can cause persistent pathological alteration of neurons. This may lead to cognitive dysfunction, depression and increased…”
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Neuronal insult either by exposure to lead or by direct neuronal damage causes genome-wide changes in DNA methylation and histone 3 lysine 36 tri-methylation by Sen, Arko

“…Prenatal and postnatal exposure to pervasive neuro-toxicants such as Lead (Pb) has been reported to causes extensive and diverse changes in the epigenetic…”
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Tutorial on running median subtraction filter with application to searches for exotic field transients in multi-messenger astronomy by Sen, Arko P, Sarantsev, Andrey, Blewitt, Geoffrey, Derevianko, Andrei

“…Running Median Subtraction Filter (RMSF) is a robust statistical tool for removing slowly varying baselines in data streams containing transients…”
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Epigenetics as an answer to Darwin’s “special difficulty,” Part 2: natural selection of metastable epialleles in honeybee castes by Ruden, Douglas M., Cingolani, Pablo E., Sen, Arko, Qu, Wen, Wang, Luan, Senut, Marie-Claude, Garfinkel, Mark D., Sollars, Vincent E., Lu, Xiangyi

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Epigenetics as an answer to Darwin's "special difficulty," Part 2: natural selection of metastable epialleles in honeybee castes by Ruden, Douglas M, Cingolani, Pablo E, Sen, Arko, Qu, Wen, Wang, Luan, Senut, Marie-Claude, Garfinkel, Mark D, Sollars, Vincent E, Lu, Xiangyi

“…In a recent perspective in this journal, Herb (2014) discussed how epigenetics is a possible mechanism to circumvent Charles Darwin's "special difficulty" in…”
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Multi-messenger astronomy in the new physics modality with GPS constellation by Sen, Arko P, Pfeffer, Kalia, Ries, Paul, Blewitt, Geoffrey, Derevianko, Andrei

“…We explore a novel, exotic physics, modality in multi-messenger astronomy. We are interested in exotic fields emitted by the mergers and their direct detection…”
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Becoming et ala by Sen, Arko

“…The thesis repeats a becoming of difference and Otherness. It seeks to fold, refold and unfold an Otherness of representation. Attention is given to the core…”
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Becoming et al by Sen, Arko

“…The thesis repeats a becoming of difference and Otherness. It seeks to fold, refold and unfold an Otherness of representation. Attention is given to the core…”
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