Search Results - "Semmrich, Monika"

A bispecific IgG format containing four independent antigen binding sites by Ljungars, Anne, Schiött, Torbjörn, Mattson, Ulrika, Steppa, Jessica, Hambe, Björn, Semmrich, Monika, Ohlin, Mats, Tornberg, Ulla-Carin, Mattsson, Mikael

“…Bispecific antibodies come in many different formats, including the particularly interesting two-in-one antibodies, where one conventional IgG binds two…”
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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Semmrich, Monika, Marchand, Jean-Baptiste, Fend, Laetitia, Rehn, Matilda, Remy, Christelle, Holmkvist, Petra, Silvestre, Nathalie, Svensson, Carolin, Kleinpeter, Patricia, Deforges, Jules, Junghus, Fred, Cleary, Kirstie L, Bodén, Mimoza, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Quéméneur, Eric, Frendéus, Björn

“…BackgroundImmune checkpoint blockade (ICB) is a clinically proven concept to treat cancer. Still, a majority of patients with cancer including those with…”
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1368 Preclinical development of an agonistic anti-TNFR2 antibody (BI-1910) for cancer immunotherapy by Martensson, Linda, Holmkvist, Petra, Kovacek, Mathilda, Svensson, Carolin, Bodén, Mimoza, Cleary, Kirstie, Dadas, Osman, Blidberg, Therese, Duell, Benjamin, Semmrich, Monika, Nilsson, Jan Anders, Beers, Stephen, Lim, Sean, Wallin, Johan E, Borggren, Marie, McAllister, Andres, Cragg, Mark, Karlsson, Ingrid, Frendeus, Bjorn, Teige, Ingrid

“…BackgroundThe pleiotropic TNF-α:TNFR axis plays a central role in the immune system. TNFR2 has been proposed to be both essential for the survival of T regs,…”
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Domain binding and isotype dictate the activity of anti-human OX40 antibodies by Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S

“…BackgroundPrevious data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice through deletion of Tregs. However, OX40 also has powerful…”
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Importance of integrin LFA-1 deactivation for the generation of immune responses by Semmrich, Monika, Smith, Andrew, Feterowski, Carolin, Beer, Sandra, Engelhardt, Britta, Busch, Dirk H, Bartsch, Bernadett, Laschinger, Melanie, Hogg, Nancy, Pfeffer, Klaus, Holzmann, Bernhard

“…The dynamic regulation of ligand binding is considered crucial for integrin function. However, the importance of activity regulation for integrin function in…”
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594 BT-001, an oncolytic vaccinia virus armed with a Treg-depleting human recombinant anti-CTLA4 antibody and GM-CSF to target the tumor microenvironment by Semmrich, Monika, Marchand, Jean-Baptiste, Fend, Laetitia, Rehn, Matilda, Silvestre, Nathalie, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Quéméneur, Eric, Frendeus, Björn

“…BackgroundCheckpoint inhibitor antibodies have improved survival in a variety of cancers, however, a great unmet need remains since only a small fraction of…”
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725 Pre-clinical development of TNFR2 ligand-blocking BI-1808 for cancer immunotherapy by Mårtensson, Linda, Kovacek, Mathilda, Holmkvist, Petra, Semmrich, Monika, Svensson, Carolin, Blidberg, Therese, Roos, Carl, McAllister, Andres, Demiri, Mimoza, Borggren, Marie, Karlsson, Ingrid, Frendeus, Björn, Teige, Ingrid

“…BackgroundThe pleiotropic TNF-alpha:TNFR axis plays a central role in the immune system. While the cellular expression of TNFR1 is broad, TNFR2 expression is…”
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Intact LFA-1 deactivation promotes T-cell activation and rejection of cardiac allograft by Hüser, Norbert, Fasan, Annette, Semmrich, Monika, Schmidbauer, Patricia, Holzmann, Bernhard, Laschinger, Melanie

“…Leucocyte function-associated antigen-1 (LFA-1) is known to be involved in immune reactions leading to allograft rejection. The role of deactivating LFA-1 in…”
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IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation by Persson, Emma K., Uronen-Hansson, Heli, Semmrich, Monika, Rivollier, Aymeric, Hägerbrand, Karin, Marsal, Jan, Gudjonsson, Sigurdur, Håkansson, Ulf, Reizis, Boris, Kotarsky, Knut, Agace, William W.

“…CD103+CD11b+ dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function…”
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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function by Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.

“…The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and…”
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Abstract 5602: BT-001, an oncolytic vaccinia virus armed with a Treg-depletion-optimized recombinant human anti-CTLA4 antibody and GM-CSF to target the tumor microenvironment by Marchand, Jean-Baptiste, Semmrich, Monika, Fend, Laetitia, Rehn, Matilda, Silvestre, Nathalie, Teige, Ingrid, Foloppe, Johann, Mårtensson, Linda, Quéméneur, Eric, Frendeus, Björn

“…Abstract Oncolytic virotherapy is a clinically validated class of immune modulatory drugs with activity in solid cancer. The mode of action of armed oncolytic…”
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Abstract 936: Targeting TNFR2 for cancer immunotherapy: Ligand blocking depletors versus receptor agonists by Mårtensson, Linda, Cleary, Kirstie, Semmrich, Monika, Kovacek, Mathilda, Holmkvist, Petra, Svensson, Caroline, Demiri, Mimoza, Blidberg, Therese, Thornberg, Ulla-Carin, Pitic, Vincentiu, Dadas, Osman, Lim, Sean H., Beers, Stephen A., Cragg, Mark S., Frendéus, Björn, Teige, Ingrid

“…Abstract The pleiotropic TNF-α:TNFR axis plays a central role in the immune system. While the cellular expression of TNFR1 is broad, TNFR2 expression is mainly…”
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Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin by Sewald, Xaver, Gebert-Vogl, Bettina, Prassl, Sandra, Barwig, Iris, Weiss, Evelyn, Fabbri, Monica, Osicka, Radim, Schiemann, Matthias, Busch, Dirk H, Semmrich, Monika, Holzmann, Bernhard, Sebo, Peter, Haas, Rainer

“…Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a…”
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Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses by Semmrich, M, Plantinga, M, Svensson-Frej, M, Uronen-Hansson, H, Gustafsson, T, Mowat, A M, Yrlid, U, Lambrecht, B N, Agace, W W

“…The αE integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the function of…”
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Abstract 3567: Comprehensive preclinical studies of BT-001: An oncolytic vaccinia virus armed with Treg-depleting @CTLA4 and GM-CSF by Marchand, Jean-Baptiste, Semmrich, Monika, Ziller, Christelle, Rehn, Matilda, Fend, Laetitia, Holmkvist, Petra, Silvestre, Nathalie, Svensson, Carolin, Patricia, Kleinpeter, Deforges, Jules, Junghus, Fred, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Frendéus, Björn, Quéméneur, Eric

“…Abstract Background Immune checkpoint blockade (ICB) is a clinically proven concept to treat cancer. Still, a majority of cancer patients including those with…”
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Abstract 4156: BI-1808 - a first in class ligand-blocking αTNFR2 antibody for cancer immunotherapy by Mårtensson, Linda, Cleary, Kirsty, Holmkvist, Petra, Kovacek, Mathilda, Svensson, Carolin, Semmrich, Monika, Blidberg, Therese, Demiri, Mimoza, Dadas, Osman, Borggren, Marie, Pitic, Vici, Lim, Sean H., Beers, Stephen A., Gertsson, Susanne, Rohrberg, Kristoffer S., Karlsson, Ingrid, McAllister, Andres, Cragg, Mark S., Frendeus, Björn, Teige, Ingrid

“…Abstract The pleiotropic TNF-α:TNFR axis plays a central role in immune regulation. While the cellular expression of TNFR1 is broad, TNFR2 expression is mainly…”
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RhoH is important for positive thymocyte selection and T-cell receptor signaling by Dorn, Tatjana, Kuhn, Ursula, Bungartz, Gerd, Stiller, Sebastian, Bauer, Martina, Ellwart, Joachim, Peters, Thorsten, Scharffetter-Kochanek, Karin, Semmrich, Monika, Laschinger, Melanie, Holzmann, Bernhard, Klinkert, Wolfgang E.F., Straten, Per Thor, Køllgaard, Tania, Sixt, Michael, Brakebusch, Cord

“…RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated that RhoH is…”
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Design and Synthesis of Potent and Selective α4β7 Integrin Antagonists by Boer, Jürgen, Gottschling, Dirk, Schuster, Anja, Semmrich, Monika, Holzmann, Bernhard, Kessler, Horst

“…Interactions of the integrins α4β7 with its cognate ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) play a crucial role in the development of…”
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Importance of integrin LFA-1 deactivation for the generation of immune responses by Semmrich, Monika, Smith, Andrew, Feterowski, Carolin, Beer, Sandra, Engelhardt, Britta, Busch, Dirk H, Bartsch, Bernadett, Laschinger, Melanie, Hogg, Nancy, Pfeffer, Klaus, Holzmann, Bernhard

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Design and Synthesis of Potent and Selective α 4 β 7 Integrin Antagonists by Boer, Jürgen, Gottschling, Dirk, Schuster, Anja, Semmrich, Monika, Holzmann, Bernhard, Kessler, Horst

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