Search Results - "Semkova, Irina"

Multifocal ERG recordings under visual control of the stimulated fundus in mice by Dutescu, Ralf M, Skosyrski, Sergej, Kociok, Norbert, Semkova, Irina, Mergler, Stefan, Atorf, Jenny, Joussen, Antonia M, Strauß, Olaf, Kremers, Jan

“…Therapeutic approaches to retinal disease require a continuous monitoring of functional improvement over lesion areas that sometimes cannot be shown in…”
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Anti-angiogenic effect of the basement membrane protein nidogen-1 in a mouse model of choroidal neovascularization by Semkova, Irina, Kociok, Norbert, Karagiannis, Dimitrios, Nischt, Roswitha, Smyth, Neil, Paulsson, Mats, Strauß, Olaf, Joussen, Antonia M.

“…In patients with age-related macular degeneration disruption of the integrity of the retinal pigment epithelium (RPE) and Bruch's membrane (BrM), precedes…”
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Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization by Semkova, Irina, Fauser, Sascha, Lappas, Alexandra, Smyth, Neil, Kociok, Norbert, Kirchhof, Bernd, Paulsson, Mats, Poulaki, Vassiliki, Joussen, Antonia M.

“…ABSTRACT Choroidal neovascularization (CNV) is responsible for the severe visual loss in age‐related macular degeneration. CNV formation is considered to be…”
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Autologous Transplantation of Genetically Modified Iris Pigment Epithelial Cells: A Promising Concept for the Treatment of Age-Related Macular Degeneration and Other Disorders of the Eye by Semkova, Irina, Kreppel, Florian, Welsandt, Gerhard, Luther, Thomas, Kozlowski, Jolanta, Janicki, Hanna, Kochanek, Stefan, Schraermeyer, Ulrich

“…Age-related macular degeneration (ARMD) is the leading cause for visual impairment and blindness in the elder population. Laser photocoagulation, photodynamic…”
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Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage by Semkova, Irina, Wolz, Philipp, Schilling, Matthias, Krieglstein, Josef

“…It has been previously demonstrated that selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, potentiates glial reaction to injury and possesses…”
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Investigation of Laser-Induced Choroidal Neovascularization in the Rat by Semkova, Irina, Peters, Swaantje, Welsandt, Gerhard, Janicki, Hanna, Jordan, Jens, Schraermeyer, Ulrich

“…Choroidal neovascularization plays an important role in pathogenesis of age-related macular degeneration. Induction of neovascularization by laser…”
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Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF by Semkova, Irina, Schilling, Matthias, Henrich-Noack, Petra, Rami, Abdelhaq, Krieglstein, Josef

“…It has been shown previously that clenbuterol, a β 2-adrenergic receptor agonist, enhances NGF synthesis in adult rat brain. Since NGF is able to protect…”
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Ciliary neurotrophic factor enhances the expression of NGF and p75 low-affinity NGF receptor in astrocytes by Semkova, Irina, Krieglstein, Josef

“…A functional interactions between ciliary neurotrophic factor (CNTF) and NGF has recently been demonstrated. We found that the exposure of rat cortical…”
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Ciliary neurotrophic factor protects hippocampal neurons from excitotoxic damage by Semkova, Irina, Häberlein, Catrin, Krieglstein, Josef

“…The loss of neurons is responsible for many acute neurological disorders as well as chronic neurodegenerative diseases. This cell loss might be prevented by a…”
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TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations by Joussen, Antonia M, Doehmen, Sven, Le, Minh L, Koizumi, Kan, Radetzky, Sven, Krohne, Tim U, Poulaki, Vassiliki, Semkova, Irina, Kociok, Norbert

“…The pathophysiology of diabetic retinopathy involves leukocyte adhesion to retinal vasculature, early blood-retinal barrier breakdown, capillary nonperfusion,…”
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Neurally Selected Embryonic Stem Cells Induce Tumor Formation after Long-Term Survival following Engraftment into the Subretinal Space by Arnhold, Stefan, Klein, Helmut, Semkova, Irina, Addicks, Klaus, Schraermeyer, Ulrich

“…To determine whether transplantation of embryonic stem (ES) cells into the subretinal space of rhodopsin-knockout mice has a tumorigenic effect. Mouse…”
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Inhibition of TNF-α reduces laser-induced choroidal neovascularization by Shi, Xuan, Semkova, Irina, Müther, Philipp S., Dell, Susanne, Kociok, Norbert, Joussen, Antonia M.

“…To investigate the role of the TNF-α in the development of laser-induced choroidal neovascularization (CNV) in a mouse model. Four separate laser burns were…”
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Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization by Jasielska, Monika, Semkova, Irina, Shi, Xuan, Schmidt, Kristina, Karagiannis, Dimitrios, Kokkinou, Despina, Mackiewicz, Jerzy, Kociok, Norbert, Joussen, Antonia M

“…Tumor necrosis factor alpha (TNF)-alpha contributes to inflammation-associated angiogenesis. This study investigates the role of TNF-alpha receptors 1a and 1b…”
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Corrigendum to “Anti-angiogenic effect of the basement membrane protein nidogen-1 in a mouse model of choroidal neovascularization” [Exp. Eye Res. 118C (2014) 80–88] by Semkova, Irina, Kociok, Norbert, Karagiannis, Dimitrios, Nischt, Roswitha, Smyth, Neil, Paulsson, Mats, Strauß, Olaf, Joussen, Antonia M.

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Corrigendum to “Retinal localization of the glutamate receptor GluR2 and GluR2-regulating proteins in diabetic rats” [Exp. Eye Res. 90 (2) (2010) 244–253] by Semkova, Irina, Huemmeke, Markus, Ho, Matthew S., Merkl, Barbara, Abari, Elizabeth, Paulsson, Mats, Joussen, Antonia M., Plomann, Markus

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Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model by Müther, Philipp S, Semkova, Irina, Schmidt, Kristina, Abari, Elizabeth, Kuebbeler, Marc, Beyer, Marc, Abken, Hinrich, Meyer, Klaus L, Kociok, Norbert, Joussen, Antonia M

“…Microglia cells have been associated with immunologic defense and repair. The course of retinal disease after lethal irradiation for bone marrow depletion and…”
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Recruitment of blood-derived inflammatory cells mediated via tumor necrosis factor-α receptor 1b exacerbates choroidal neovascularization by Semkova, Irina, Muether, Philipp S, Kuebbeler, Mark, Meyer, Klaus L, Kociok, Norbert, Joussen, Antonia M

“…Purpose. Tumor necrosis factor (TNF)-α contributes to inflammation-associated angiogenesis, and TNF-α receptor 1b is selectively expressed on immuno-competent…”
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Deposition of nidogens and other basement membrane proteins in the young and aging mouse retina by Kunze, Alexander, Abari, Elizabeth, Semkova, Irina, Paulsson, Mats, Hartmann, Ursula

“…To determine the distribution of major basement membrane constituents, particularly nidogen 1 and 2, in young and aging mouse retinae. The specificity of…”
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S-100β protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT1A-receptor agonist, Bay x 3702 by AHLEMEYER, B, BEIER, H, SEMKOVA, I, SCHAPER, C, KRIEGLSTEIN, J

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Retinal localization of the glutamate receptor GluR2 and GluR2-regulating proteins in diabetic rats by Semkova, Irina, Huemmeke, Markus, Ho, Matthew S., Merkl, Barbara, Abari, Elizabeth, Paulsson, Mats, Joussen, Antonia M., Plomann, Markus

“…Impaired glutamatergic activity and synaptic dysfunction contributing to excitotoxicity and neuronal degeneration has been observed in the diabetic retina…”
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