Search Results - "Seminars in liver disease"

Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets by Yang, Yoon Mee, Kim, So Yeon, Seki, Ekihiro

“…Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising from different etiologies, including hepatitis B and C and…”
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Overview of microRNA biology by Mohr, Ashley M, Mott, Justin L

“…In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to…”
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Acetaminophen Hepatotoxicity by Ramachandran, Anup, Jaeschke, Hartmut

“…Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is frequently implicated in…”
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Regression of Liver Fibrosis by Campana, Lara, Iredale, John P

“…Liver fibrosis is the final common pathway of chronic or iterative liver damage. Advanced chronic fibrosis is described as cirrhosis with a loss of…”
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The Micro-Elimination Approach to Eliminating Hepatitis C: Strategic and Operational Considerations by Lazarus, Jeffrey V, Safreed-Harmon, Kelly, Thursz, Mark R, Dillon, John F, El-Sayed, Manal H, Elsharkawy, Ahmed M, Hatzakis, Angelos, Jadoul, Michel, Prestileo, Tullio, Razavi, Homie, Rockstroh, Jürgen K, Wiktor, Stefan Z, Colombo, Massimo

“…The introduction of efficacious new hepatitis C virus (HCV) treatments galvanized the World Health Organization to define ambitious targets for eliminating HCV…”
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NASH in Lean Individuals by Younes, Ramy, Bugianesi, Elisabetta

“…Nonalcoholic fatty liver disease (NAFLD) is generally associated with obesity and the related comorbidities but it can also develop in subjects with a body…”
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Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease by Satapathy, Sanjaya K, Sanyal, Arun J

“…The epidemic of obesity has resulted in a parallel incremental burden of nonalcoholic fatty liver disease (NAFLD) worldwide. Nonalcoholic fatty liver disease…”
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Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis by Matsuda, Michitaka, Seki, Ekihiro

“…Chronic liver injury due to viral hepatitis, alcohol abuse, and metabolic disorders is a worldwide health concern. Insufficient treatment of chronic liver…”
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Heterogeneity of patients with intermediate (BCLC B) Hepatocellular Carcinoma: proposal for a subclassification to facilitate treatment decisions by Bolondi, Luigi, Burroughs, Andrew, Dufour, Jean-François, Galle, Peter R, Mazzaferro, Vincenzo, Piscaglia, Fabio, Raoul, Jean Luc, Sangro, Bruno

“…The intermediate stage of hepatocellular carcinoma (HCC) comprises a highly heterogeneous patient population and therefore poses unique challenges for…”
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Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis by Maiers, Jessica L, Malhi, Harmeet

“…Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic fibrosis, but the role it plays varies depending on the cause and…”
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Modified RECIST (mRECIST) assessment for hepatocellular carcinoma by Lencioni, Riccardo, Llovet, Josep M

“…The endpoint in cancer research is overall survival. Nonetheless, other potential surrogate endpoints, such as response rate and time to progression, are…”
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The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review by Lleo, Ana, Leung, Patrick S C, Hirschfield, Gideon M, Gershwin, Eric M

“…Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by autoimmune destruction of small to medium size intrahepatic bile…”
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Inflammasomes in Liver Fibrosis by Alegre, Fernando, Pelegrin, Pablo, Feldstein, Ariel E

“…Cell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in…”
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Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity by Arrese, Marco, Arab, Juan P, Barrera, Francisco, Kaufmann, Benedikt, Valenti, Luca, Feldstein, Ariel E

“…The acronym nonalcoholic fatty-liver disease (NAFLD) groups a heterogeneous patient population. Although in many patients the primary driver is metabolic…”
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Nonalcoholic Fatty Liver Disease in Children by Mann, Jake P, Valenti, Luca, Scorletti, Eleonora, Byrne, Christopher D, Nobili, Valerio

“…Nonalcoholic steatohepatitis, a progressive form of nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in children who…”
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Macrophages: master regulators of inflammation and fibrosis by Wynn, Thomas A, Barron, Luke

“…Macrophages are found in close proximity with collagen-producing myofibroblasts and indisputably play a key role in fibrosis. They produce profibrotic…”
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Hepatocellular Carcinoma with Portal Vein Tumor Involvement: Best Management Strategies by Liu, Po-Hong, Huo, Teh-Ia, Miksad, Rebecca A

“…Portal vein tumor thrombosis (PVTT) commonly occurs in patients with hepatocellular carcinoma (HCC). Patients with PVTT usually have an aggressive disease…”
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Liver Sinusoidal Endothelial Cell: An Update by DeLeve, Laurie D, Maretti-Mira, Ana C

“…This update focuses on two main topics. First, recent developments in our understanding of liver sinusoidal endothelial cell (LSEC) function will be reviewed,…”
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Current strategy for staging and treatment: the BCLC update and future prospects by Forner, Alejandro, Reig, María E, de Lope, Carlos Rodriguez, Bruix, Jordi

“…Staging and treatment indication are relevant topics in the management of patients with hepatocellular carcinoma (HCC) and for optimal results, they have to…”
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Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP by Xu, Xu, So, Jae-Seon, Park, Jong-Gil, Lee, Ann-Hwee

“…The liver is a central organ that controls systemic energy homeostasis and nutrient metabolism. Dietary carbohydrates and lipids, and fatty acids derived from…”
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