Search Results - "Seminars in hematology"

Anemia in Clinical Practice—Definition and Classification: Does Hemoglobin Change With Aging? by Domenica Cappellini, M, Motta, Irene

“…Anemia is a global public health problem affecting both developing and developed countries at all ages. According to the World Health Organization (WHO),…”
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GATA2 deficiency and related myeloid neoplasms by Wlodarski, Marcin W, Collin, Matthew, Horwitz, Marshall S

“…Abstract The GATA2 gene codes for a hematopoietic transcription factor that through its two zinc fingers (ZF) can occupy GATA-DNA motifs in a countless number…”
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A 50-Year Journey to Cure Childhood Acute Lymphoblastic Leukemia by Pui, Ching-Hon, Evans, William E

“…The 50th anniversary of Seminars in Hematology coincides with the 50th anniversary of St. Jude Children's Research Hospital, and both milestones are inexorably…”
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Memory-like natural killer cells for cancer immunotherapy by Gang, Margery, Wong, Pamela, Berrien-Elliott, Melissa M., Fehniger, Todd A.

“…•NK cell are innate lymphoid cells that exhibit memory and memory-like responses.•Cytokine-induced memory-like (ML) NK cells are induced via IL-12, IL-15, and…”
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B-Cell Receptor Signaling in Diffuse Large B-Cell lymphoma by Young, Ryan M, Shaffer, Arthur L, Phelan, James D, Staudt, Louis M

“…The importance of understanding the genetic and biochemical basis of B-cell receptor (BCR) survival signaling in diffuse large B-cell lymphoma (DLBCL) is…”
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Genetic and epigenetic determinants of AML pathogenesis by Cai, Sheng F., Levine, Ross L.

“…Acute myeloid leukemia (AML) was one of the first cancers to be sequenced at the level of the whole genome. Molecular profiling of AML through targeted…”
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Iron metabolism in infections: Focus on COVID-19 by Girelli, Domenico, Marchi, Giacomo, Busti, Fabiana, Vianello, Alice

“…Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living organisms. During infections, a battle for iron takes place…”
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Toward a pathophysiology inspired treatment of VEXAS syndrome by Heiblig, Maël, Patel, Bhavisha A., Groarke, Emma M., Bourbon, Estelle, Sujobert, Pierre

“…VEXAS syndrome has an unmet need for therapeutic interventions. Even if few data exist regarding the treatment of this newly described syndrome, different…”
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Aplastic anemia: Pathophysiology by Giudice, Valentina, Selleri, Carmine

“…Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions characterized by uni- or multi-lineage marrow and/or…”
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Rituximab: Mechanism of Action by Weiner, George J

“…Rituximab is a mainstay in the therapy for a broad variety of B-cell malignancies. Despite its undeniable therapeutic value, we still do not fully understand…”
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Platelet-activating anti-PF4 disorders: An overview by Warkentin, Theodore E.

“…Platelet factor 4 (PF4) is a highly cationic tetrameric protein that can be targeted by platelet-activating anti-PF4 antibodies of immunoglobulin G (IgG)…”
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Hodgkin lymphoma: Pathology and biology by Mathas, Stephan, Hartmann, Sylvia, Küppers, Ralf

“…Abstract The Hodgkin and Reed-Sternberg (HRS) tumor cells of classical Hodgkin lymphoma (HL), as well as the lymphocyte predominant (LP) cells of nodular…”
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Iron Deficiency Anemia in Pregnancy by Breymann, Christian

“…Anemia is a common problem in obstetrics and perinatal care. Any hemoglobin below 10.5 g/dL can be regarded as true anemia regardless of gestational age…”
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Epidemiology of VITT by Pai, Menaka

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a life-threatening syndrome of aggressive thrombosis, often profound thrombocytopenia, and…”
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Treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT) by Gabarin, Nadia, Arnold, Donald M., Nazy, Ishac, Warkentin, Theodore E.

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a novel prothrombotic disorder characterized by thrombosis, thrombocytopenia, and disseminated…”
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Characteristic bone marrow findings in patients with UBA1 somatic mutations and VEXAS syndrome by Patel, Nisha, Dulau-Florea, Alina, Calvo, Katherine R.

“…VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a newly characterized syndrome with underlying somatic UBA1 mutations in myeloid cells…”
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The Genetic Landscape of Diffuse Large B-Cell Lymphoma by Pasqualucci, Laura, Dalla-Favera, Riccardo

“…Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in the western world, is an aggressive disease that remains incurable in…”
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Clonal hematopoiesis by Jan, Max, Ebert, Benjamin L, Jaiswal, Siddhartha

“…Abstract Cancer results from multistep pathogenesis, yet the pre-malignant states that precede the development of many hematologic malignancies have been…”
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Haploidentical bone marrow and stem cell transplantation: experience with post-transplantation cyclophosphamide by Robinson, Tara M, O’Donnell, Paul V, Fuchs, Ephraim J, Luznik, Leo

“…Abstract Allogeneic blood or bone marrow transplantation (BMT) is a potentially curative therapy for high-risk hematologic malignancies not curable by standard…”
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Pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT) by Greinacher, Andreas, Schönborn, Linda, Siegerist, Florian, Steil, Leif, Palankar, Raghavendra, Handtke, Stefan, Reder, Alexander, Thiele, Thomas, Aurich, Konstanze, Methling, Karen, Lalk, Michael, Völker, Uwe, Endlich, Nicole

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT; synonym, thrombosis with thrombocytopenia syndrome, is associated with high-titer immunoglobulin G…”
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