Search Results - "Semenza, Gregg L"

The hypoxic tumor microenvironment: A driving force for breast cancer progression by Semenza, Gregg L.

“…Intratumoral hypoxia is a common finding in breast cancer and is associated with a significantly increased risk of metastasis and patient mortality…”
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Pharmacologic Targeting of Hypoxia-Inducible Factors by Semenza, Gregg L

“…Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O 2 availability. HIFs are heterodimeric proteins composed of an O 2 -regulated…”
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Hypoxia-Inducible Factors in Physiology and Medicine by Semenza, Gregg L.

“…Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible…”
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Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology by Semenza, Gregg L

“…Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders…”
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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy by Semenza, Gregg L

“…Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In human cancers that are accessible for O2 electrode measurements,…”
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Hypoxia-inducible factor 1 and cardiovascular disease by Semenza, Gregg L

“…Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain…”
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Hypoxia-inducible factors: cancer progression and clinical translation by Wicks, Elizabeth E, Semenza, Gregg L

“…Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult…”
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Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning by Semenza, Gregg L.

“…Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to reduced oxygen availability by regulating gene expression. A critical cell-autonomous…”
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Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche by Suda, Toshio, Takubo, Keiyo, Semenza, Gregg L.

“…Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs)…”
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Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1 by Semenza, Gregg L

“…Gregg L. Semenza Vascular Program, Institute for Cell Engineering, McKusick-Nathans Institute of Genetic Medicine, and Departments of Pediatrics, Medicine,…”
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Molecular mechanisms mediating metastasis of hypoxic breast cancer cells by Semenza, Gregg L

“…Breast cancers contain regions of intratumoral hypoxia in which reduced O2 availability activates the hypoxia-inducible factors HIF-1 and HIF-2, which increase…”
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Hypoxia-Inducible Factors: Master Regulators of Cancer Progression by Schito, Luana, Semenza, Gregg L

“…Intratumoral hypoxia (reduced O availability) is a common finding in human cancer and leads to increased activity of hypoxia-inducible factors (HIFs), which…”
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Tumor metabolism: cancer cells give and take lactate by Semenza, Gregg L

“…Tumors contain well-oxygenated (aerobic) and poorly oxygenated (hypoxic) regions, which were thought to utilize glucose for oxidative and glycolytic…”
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Regulation of cell proliferation by hypoxia-inducible factors by Hubbi, Maimon E, Semenza, Gregg L

“…Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and…”
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Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1 by Semenza, Gregg L

“…The survival of metazoan organisms is dependent upon the utilization of O2 as a substrate for COX (cytochrome c oxidase), which constitutes Complex IV of the…”
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Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2 by Prabhakar, Nanduri R, Semenza, Gregg L

“…Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and…”
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Emerging roles of PKM2 in cell metabolism and cancer progression by Luo, Weibo, Semenza, Gregg L

“…Increased conversion of glucose to lactate is a key feature of many cancer cells that promotes rapid growth. Pyruvate kinase M2 (PKM2) expression is increased…”
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Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis by Semenza, Gregg L.

“…Red blood cells deliver O2 from the lungs to every cell in the human body. Reduced tissue oxygenation triggers increased production of erythropoietin by…”
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Oxygen Sensing and Homeostasis by Prabhakar, Nanduri R, Semenza, Gregg L

“…The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of…”
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Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells by Samanta, Debangshu, Gilkes, Daniele M, Chaturvedi, Pallavi, Xiang, Lisha, Semenza, Gregg L

“…Significance Breast cancer stem cells play essential roles in tumor growth, maintenance, and recurrence after chemotherapy. We report that treatment of human…”
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