Search Results - "Semeins, C.M."

Inhibition of osteocyte apoptosis by fluid flow is mediated by nitric oxide by Tan, S.D., Bakker, A.D., Semeins, C.M., Kuijpers-Jagtman, A.M., Klein-Nulend, J.

“…Bone unloading results in osteocyte apoptosis, which attracts osteoclasts leading to bone loss. Loading of bone drives fluid flow over osteocytes which respond…”
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Influence of nanostructural environment and fluid flow on osteoblast-like cell behavior: A model for cell-mechanics studies by Prodanov, L., Semeins, C.M., van Loon, J.J.W.A., te Riet, J., Jansen, J.A., Klein-Nulend, J., Walboomers, X.F.

“…Introducing nanoroughness on various biomaterials has been shown to profoundly effect cell-material interactions. Similarly, physical forces act on a diverse…”
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NO signaling in mechanical adaptation of bone by Klein-Nulend, J, Bacabac, R.G, Vatsa, A, Semeins, C.M, Bakker, A.D

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Differential Stimulation of Prostaglandin G/H Synthase-2 in Osteocytes and Other Osteogenic Cells by Pulsating Fluid Flow by Westbroek, I., Ajubi, N.E., Alblas, M.J., Semeins, C.M., Klein-Nulend, J., Burger, E.H., Nijweide, P.J.

“…Mechanical stress produces flow of fluid in the osteocytic lacunar–canalicular network, which is likely the physiological signal for the adaptive response of…”
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Paxillin localisation in osteocytes—Is it determined by the direction of loading? by Vatsa, A., Semeins, C.M., Smit, T.H., Klein-Nulend, J.

“…External mechanical loading of cells aligns cytoskeletal stress fibres in the direction of principle strains and localises paxillin to the mechanosensing…”
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Fluid Shear Stress Inhibits TNFα-induced Osteocyte Apoptosis by Tan, S.D., Kuijpers-Jagtman, A.M., Semeins, C.M., Bronckers, A.L.J.J., Maltha, J.C., Von den Hoff, J.W., Everts, V., Klein-Nulend, J.

“…Bone tissue can adapt to orthodontic load. Mechanosensing in bone is primarily a task for the osteocytes, which translate the canalicular flow resulting from…”
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Pulsating Fluid Flow Increases Nitric Oxide (NO) Synthesis by Osteocytes but Not Periosteal Fibroblasts - Correlation with Prostaglandin Upregulation by Kleinnulend, J., Semeins, C.M., Ajubi, N.E., Nijweide, P.J., Burger, E.H.

“…Osteocytes are extremely sensitive to fluid shear stress, a phenomenon that may be related to mechanical adaptation of bone (FASEB J 9:441,1995). Here we…”
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Nitric Oxide Response to Shear Stress by Human Bone Cell Cultures Is Endothelial Nitric Oxide Synthase Dependent by Klein-Nulend, J., Helfrich, M.H., Sterck, J.G.H., MacPherson, H., Joldersma, M., Ralston, S.H., Semeins, C.M., Burger, E.H.

“…Bone cells, in particular osteocytes, are extremely sensitive to shear stress, a phenomenon that may be related to mechanical adaptation of bone. In this study…”
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Stimulation of bone cell differentiation by low-intensity ultrasound––a histomorphometric in vitro study by Korstjens, C.M, Nolte, P.A, Burger, E.H, Albers, G.H.R, Semeins, C.M, Aartman, I.H.A, Goei, S.W, Klein-Nulend, J

“…Several investigations have established a stimulatory effect of low-intensity ultrasound treatment on osteogenesis and fracture healing. The objective of this…”
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Low-intensity ultrasound stimulates endochondral ossification in vitro by Nolte, P.A, Klein-Nulend, J, Albers, G.H.R, Marti, R.K, Semeins, C.M, Goei, S.W, Burger, E.H

“…Animal and clinical studies have shown an acceleration of bone healing by the application of low-intensity ultrasound. The objective of this study was to…”
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Osteopontin-Deficient Bone Cells Are Defective in Their Ability to Produce NO in Response to Pulsatile Fluid Flow by Denhardt, D.T., Burger, E.H., Kazanecki, C., Krishna, S., Semeins, C.M., Klein-Nulend, J.

“…Osteopontin (OPN) is a noncollagenous component of bone matrix. It mediates cell attachment and activates signal transduction pathways. In this work, bone…”
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Opposite effects of osteogenic protein and transforming growth factor β on chondrogenesis in cultured long bone rudiments by Dieudonné, S.C., Semeins, C.M., Goei, S.W., Vukicevic, S., Nulend, Klein J., Sampath, T.K., Helder, M., Burger, E.H.

“…Osteogenic protein‐1 (OP‐1, also called BMP‐7) is a bone morphogenetic member of the TGF‐β superfamily. In the present study, we examined the effect of…”
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Pulsatile fluid flow stimulates nitric oxide (NO) production by osteocytes, but not periosteal fibroblasts by Klein-Nulend, J., Burger, E.H., Semeins, C.M., Ajubi, N.E., Niiweide, P.J.

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Stimulation of cartilage differentiation by osteogenic protein-1 in cultures of human perichondrium by Klein-Nulend, J, Semeins, C M, Mulder, J W, Winters, H A, Goei, S W, Ooms, M E, Burger, E H

“…Exposure of progenitor cells with chondrogenic potential to recombinant human osteogenic protein-1 [rhOP-1, or bone morphogenetic protein-7 (BMP-7] may be of…”
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