Search Results - "Sembulingam, Tamilzhalagan"
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Amplified 7q21‐22 gene MCM7 and its intronic miR‐25 suppress COL1A2 associated genes to sustain intestinal gastric cancer features
Published in Molecular carcinogenesis (01-06-2017)“…Frequent amplification of 7q21‐22 genomic region is known in gastric cancer. Multiple genes including SHFM1, MCM7, and COL1A2 were reported to be the potential…”
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Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India
Published in Scientific reports (16-07-2019)“…Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium…”
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Whole-Genome Sequencing to Identify Missed Rifampicin and Isoniazid Resistance Among Tuberculosis Isolates-Chennai, India, 2013-2016
Published in Frontiers in microbiology (22-11-2021)“…India has a high burden of drug-resistant tuberculosis (DR TB) and many cases go undetected by current drug susceptibility tests (DSTs). This study was…”
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Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India
Published in Microbiology spectrum (01-06-2022)“…Current knowledge on resistance-conferring determinants in Mycobacterium tuberculosis is biased toward globally dominant lineages 2 and 4. In contrast,…”
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Juxtaposed genes in 7q21‐22 amplicon contribute for two major gastric cancer sub‐Types by mutual exclusive expression
Published in Molecular carcinogenesis (01-04-2017)“…Genomic Copy Number Variations (CNV) and the associated gene signatures are useful for cancer prognosis, diagnosis, and targeted therapeutics. Earlier, 7q21‐22…”
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Upregulated, 7q21–22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer
Published in Cellular signalling (01-06-2015)“…Chromosomal aberrations are hallmarks of cancers and the locus of frequent genomic amplifications often harbors key cancer driver genes. Many genomic amplicons…”
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Whole genome sequencing of bacteriophage NINP13076 isolated against Salmonella enteritidis
Published in Ecological genetics and genomics (01-03-2024)“…Salmonella ranks among the prominent etiological agents responsible for foodborne illnesses on a global scale. Within the scope of this investigation, a…”
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