Search Results - "Selwood, L"

Two- and Three-dimensional Rings in Drugs by Aldeghi, Matteo, Malhotra, Shipra, Selwood, David L., Chan, Ah Wing Edith

“…Using small, flat aromatic rings as components of fragments or molecules is a common practice in fragment‐based drug discovery and lead optimization. With an…”
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Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles by Ramirez, Adrian, Old, William, Selwood, David L., Liu, Xuedong

“…The PINK1/Parkin pathway plays an important role in maintaining a healthy pool of mitochondria. Activation of this pathway can lead to apoptosis, mitophagy, or…”
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Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis by Warne, Justin, Pryce, Gareth, Hill, Julia M., Shi, Xiao, Lennerås, Felicia, Puentes, Fabiola, Kip, Maarten, Hilditch, Laura, Walker, Paul, Simone, Michela I., Chan, A.W. Edit, Towers, Greg J., Coker, Alun R., Duchen, Michael R., Szabadkai, Gyorgy, Baker, David, Selwood, David L.

“…The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for…”
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Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing by Sevastou, Ioanna, Pryce, Gareth, Baker, David, Selwood, David L

“…Multiple sclerosis (MS) is a debilitating immune-mediated neurological disorder affecting young adults. MS is primarily relapsing-remitting, but…”
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Hepatitis C virus exploits cyclophilin A to evade PKR by Colpitts, Che C, Ridewood, Sophie, Schneiderman, Bethany, Warne, Justin, Tabata, Keisuke, Ng, Caitlin F, Bartenschlager, Ralf, Selwood, David L, Towers, Greg J

“…Counteracting innate immunity is essential for successful viral replication. Host cyclophilins (Cyps) have been implicated in viral evasion of host antiviral…”
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Tuftsin signals through its receptor neuropilin‐1 via the transforming growth factor beta pathway by Nissen, Jillian C., Selwood, David L., Tsirka, Stella E.

“…Tuftsin (Thr‐Lys‐Pro‐Arg) is a natural immunomodulating peptide found to stimulate phagocytosis in macrophages/microglia. Tuftsin binds to the receptor…”
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Neuroprotection in an Experimental Model of Multiple Sclerosis via Opening of Big Conductance, Calcium-Activated Potassium Channels by Pryce, Gareth, Sisay, Sofia, Giovannoni, Gavin, Selwood, David L, Baker, David

“…Big conductance calcium-activated (BK) channel openers can inhibit pathologically driven neural hyperactivity to control symptoms via hyperpolarizing signals…”
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Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis by Sisay, Sofia, Pryce, Gareth, Jackson, Samuel J, Tanner, Carolyn, Ross, Ruth A, Michael, Gregory J, Selwood, David L, Giovannoni, Gavin, Baker, David

“…Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the…”
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Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction by Jarvis, Ashley, Allerston, Charles K, Jia, Haiyan, Herzog, Birger, Garza-Garcia, Acely, Winfield, Natalie, Ellard, Katie, Aqil, Rehan, Lynch, Rosemary, Chapman, Chris, Hartzoulakis, Basil, Nally, James, Stewart, Mark, Cheng, Lili, Menon, Malini, Tickner, Michelle, Djordjevic, Snezana, Driscoll, Paul C, Zachary, Ian, Selwood, David L

“…We report the molecular design and synthesis of EG00229, 2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural…”
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Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice by Smith, Katie E, Browne, Lorcan, Selwood, David L, McAlpine, David, Jagger, Daniel J

“…Spiral ganglion neurons (SGNs) relay acoustic code from cochlear hair cells to the brainstem, and their stimulation enables electrical hearing via cochlear…”
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Oligodendrocytes, BK channels and the preservation of myelin [version 2; peer review: 2 approved] by Rupnik, Maddalena, Baker, David, Selwood, David L

“…Oligodendrocytes wrap multiple lamellae of their membrane, myelin, around axons of the central nervous system (CNS), to improve impulse…”
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Emerging small-molecule treatments for multiple sclerosis: focus on B cells [version 1; peer review: 2 approved] by Gregson, Aaron, Thompson, Kaitlyn, Tsirka, Stella E, Selwood, David L

“…Multiple sclerosis (MS) is a major cause of disability in young adults. Following an unknown trigger (or triggers), the immune system attacks the myelin sheath…”
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VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins by Eldrid, Charles, Zloh, Mire, Fotinou, Constantina, Yelland, Tamas, Yu, Lefan, Mota, Filipa, Selwood, David L, Djordjevic, Snezana

“…Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels' formation and function. Each of the proteins from the…”
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The production of mature oocytes from adult ovaries following primary follicle culture in a marsupial by Nation, A, Selwood, L

“…A model marsupial culture system has been developed whereby individual primary follicles, obtained from adult ovaries, can be grown in vitro to the antral…”
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Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization by Lo, Alvin W. H., Van de Water, Karen, Gane, Paul J., Chan, A.W. Edith, Steadman, David, Stevens, Kiri, Selwood, David L., Waksman, Gabriel, Remaut, Han

“…Objectives To identify and to characterize small-molecule inhibitors that target the subunit polymerization of the type 1 pilus assembly in uropathogenic…”
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Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets by Briston, Thomas, Selwood, David L., Szabadkai, Gyorgy, Duchen, Michael R.

“…Mitochondrial permeability transition, as the consequence of opening of a mitochondrial permeability transition pore (mPTP), is a cellular catastrophe…”
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Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling by Jia, Haiyan, Bagherzadeh, Azadeh, Hartzoulakis, Basil, Jarvis, Ashley, Löhr, Marianne, Shaikh, Shaheda, Aqil, Rehan, Cheng, Lili, Tickner, Michelle, Esposito, Diego, Harris, Richard, Driscoll, Paul C., Selwood, David L., Zachary, Ian C.

“…Neuropilin-1 (NP-1) is a receptor for vascular endothelial growth factor-A165 (VEGF-A165) in endothelial cells. To define the role of NP-1 in the biological…”
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The Cannabinoid-Like Compound, VSN16R, Acts on Large Conductance, Ca2+-Activated K+ Channels to Modulate Hippocampal CA1 Pyramidal Neuron Firing by Tabatabaee, Setareh, Baker, David, Selwood, David L., Whalley, Benjamin J., Stephens, Gary J.

“…Large conductance, Ca2+-activated K+ (BKCa) channels are widely expressed in the central nervous system, where they regulate action potential duration, firing…”
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Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy by Culley, Siân, Towers, Greg J, Selwood, David L, Henriques, Ricardo, Grove, Joe

“…The ability to accurately and reliably quantify viral infection is essential to basic and translational virology research. Here, we describe a simple and…”
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Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease by Mills, Clare, Hemkemeyer, Sandra A, Alimajstorovic, Zerin, Bowers, Chantelle, Eskandarpour, Malihe, Greenwood, John, Calder, Virginia, Chan, A W Edith, Gane, Paul J, Selwood, David L, Matter, Karl, Balda, Maria S

“…Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide…”
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