Protocol for a single-centre, parallel-arm, double-blind randomised trial evaluating the effects of tourniquet use in total knee arthroplasty on intra-operative and post-operative outcomes

Tourniquet use during total knee replacement is common, yet uncertainty exists regarding its benefits and harms. The primary aim of the current study is to investigate whether tourniquet use during total knee replacement leads to greater reduction in quadriceps strength than non-tourniquet use at th...

Full description

Saved in:

Bibliographic Details
Published in:	BMC musculoskeletal disorders Vol. 19; no. 1; p. 435
Main Authors:	Page, Richard S, Williams, Simon, Selvaratnam, Avanthi, Waring, Shaun, Conroy, Myles, Thomson, Andrew, Beattie, Sally, Ganeshalingam, Rekha, Gill, Stephen D
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 06-12-2018 BioMed Central BMC
Subjects:	Adolescent Adult Analgesia Analgesics, Opioid - therapeutic use Analysis Arthroplasty Arthroplasty (knee) Arthroplasty, Replacement, Knee - adverse effects Arthroplasty, Replacement, Knee - methods Blood Loss, Surgical - prevention & control Cement Clinical decision making Clinical trials Decision making Double-Blind Method Double-blind studies Gangrene Hospitals Humans Joint surgery Knee Knee arthroplasty Knee pain Knee replacement arthroplasty Length of Stay Medical research Morphine - therapeutic use Muscle Strength - physiology Musculoskeletal diseases Narcotics Operative Time Orthopedic surgery Pain Pain perception Pain, Postoperative - drug therapy Patient Satisfaction Physicians Postoperative Complications - physiopathology Quadriceps muscle Quadriceps Muscle - physiopathology Quadriceps strength Quality of Life Randomized Controlled Trials as Topic Regression analysis Retirement benefits Self Report Study Protocol Surgeons Surgery Tourniquet Tourniquets - adverse effects Visual field Young Adult New Zealand Australia Knee pain Tourniquet Knee arthroplasty Quadriceps strength
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Tourniquet use during total knee replacement is common, yet uncertainty exists regarding its benefits and harms. The primary aim of the current study is to investigate whether tourniquet use during total knee replacement leads to greater reduction in quadriceps strength than non-tourniquet use at three months post-surgery. Secondary aims include investigating the effects of tourniquet use on: quadriceps strength at day 2 and 5, and 12 months post-surgery; pain and analgesia requirements; self-reported physical function and quality of life; blood loss and replacement; surgeon satisfaction with the intra-operative visual field; operation and anaesthetic time; complications; cement mantle quality; patient satisfaction; and hospital length of stay. The study is a single centre, parallel-arm, double-blind (participant and assessor), randomised trial with 1:1 random allocation. Participants will be undergo total knee replacement with or without tourniquet. Linear mixed models will be used for group comparisons of continuous outcomes available at multiple timepoints. Other continuous outcomes that are assessed at baseline and once/twice at follow-up will be analysed using linear regression. Categorical outcomes will be analysed using logistic regression models. This study will provide high-quality evidence regarding the effects of tourniquet use during total knee replacement, which can be used to inform surgeon decision-making. Australian New Zealand Clinical Trials Registry ACTRN12618000425291 . Retrospectively registered 23 March 2018.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1471-2474 1471-2474
DOI:	10.1186/s12891-018-2352-8