Search Results - "Selvarajan, Ilakya"

A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies by Härkönen, Jouni, Pölönen, Petri, Deen, Ashik Jawahar, Selvarajan, Ilakya, Teppo, Hanna-Riikka, Dimova, Elitsa Y., Kietzmann, Thomas, Ahtiainen, Maarit, Väyrynen, Juha P., Väyrynen, Sara A., Elomaa, Hanna, Tynkkynen, Niko, Eklund, Tiia, Kuopio, Teijo, Talvitie, Eva-Maria, Taimen, Pekka, Kallajoki, Markku, Kaikkonen, Minna U., Heinäniemi, Merja, Levonen, Anna-Liisa

“…The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently…”
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Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells by Deen, Ashik Jawahar, Adinolfi, Simone, Härkönen, Jouni, Patinen, Tommi, Liu, Xiaonan, Laitinen, Tuomo, Takabe, Piia, Kainulainen, Kirsi, Pasonen-Seppänen, Sanna, Gawriyski, Lisa M., Arasu, Uma Thanigai, Selvarajan, Ilakya, Mäkinen, Petri, Laitinen, Hanna, Kansanen, Emilia, Kaikkonen, Minna U., Poso, Antti, Varjosalo, Markku, Levonen, Anna-Liisa

“…The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2 -related factor 2 (NRF2) pathway is the major transcriptional stress response…”
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Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction by Kaikkonen, Minna U, Halonen, Paavo, Liu, Oscar Hsin-Fu, Turunen, Tiia A, Pajula, Juho, Moreau, Pierre, Selvarajan, Ilakya, Tuomainen, Tomi, Aavik, Einari, Tavi, Pasi, Ylä-Herttuala, Seppo

“…Microarrays and RNA sequencing are widely used to profile transcriptome remodeling during myocardial ischemia. However, the steady-state RNA analysis lacks in…”
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MGEx-Udb: a mammalian uterus database for expression-based cataloguing of genes across conditions, including endometriosis and cervical cancer by Bajpai, Akhilesh K, Davuluri, Sravanthi, Chandrashekar, Darshan S, Ilakya, Selvarajan, Dinakaran, Mahalakshmi, Acharya, Kshitish K

“…Gene expression profiling of uterus tissue has been performed in various contexts, but a significant amount of the data remains underutilized as it is not…”
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Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci by Örd, Tiit, Õunap, Kadri, Stolze, Lindsey K., Aherrahrou, Redouane, Nurminen, Valtteri, Toropainen, Anu, Selvarajan, Ilakya, Lönnberg, Tapio, Aavik, Einari, Ylä-Herttuala, Seppo, Civelek, Mete, Romanoski, Casey E., Kaikkonen, Minna U.

“…Supplemental Digital Content is available in the text. Genome-wide association studies have identified hundreds of loci associated with coronary artery disease…”
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Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits by Stolze, Lindsey K., Conklin, Austin C., Whalen, Michael B., López Rodríguez, Maykel, Õunap, Kadri, Selvarajan, Ilakya, Toropainen, Anu, Örd, Tiit, Li, Jin, Eshghi, Anna, Solomon, Alice E., Fang, Yun, Kaikkonen, Minna U., Romanoski, Casey E.

“…The identification of causal variants and mechanisms underlying complex disease traits in humans is important for the progress of human disease genetics; this…”
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Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis by Ravindran, Aarthi, Holappa, Lari, Niskanen, Henri, Skovorodkin, Ilya, Kaisto, Susanna, Beter, Mustafa, Kiema, Miika, Selvarajan, Ilakya, Nurminen, Valtteri, Aavik, Einari, Aherrahrou, Rédouane, Pasonen-Seppänen, Sanna, Fortino, Vittorio, Laakkonen, Johanna P, Ylä-Herttuala, Seppo, Vainio, Seppo, Örd, Tiit, Kaikkonen, Minna U

“…Vascular smooth muscle cells (SMCs) and their derivatives are key contributors to the development of atherosclerosis. However, studying changes in SMC gene…”
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Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci by Örd, Tiit, Õunap, Kadri, Stolze, Lindsey K., Aherrahrou, Redouane, Nurminen, Valtteri, Toropainen, Anu, Selvarajan, Ilakya, Lönnberg, Tapio, Aavik, Einari, Ylä-Herttuala, Seppo, Civelek, Mete, Romanoski, Casey E., Kaikkonen, Minna U

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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro by Selvarajan, Ilakya, Kiema, Miika, Huang, Ru-Ting, Li, Jin, Zhu, Jiayu, Pölönen, Petri, Örd, Tiit, Õunap, Kadri, Godiwala, Mehvash, Golebiewski, Anna Kathryn, Ravindran, Aarthi, Mäklin, Kiira, Toropainen, Anu, Stolze, Lindsey K, Arce, Maximiliano, Magnusson, Peetra U, White, Stephen, Romanoski, Casey E, Heinäniemi, Merja, Laakkonen, Johanna P, Fang, Yun, Kaikkonen-Määttä, Minna

“…CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which is associated with the genetic risk of…”
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Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease by Selvarajan, Ilakya, Toropainen, Anu, Garske, Kristina M., López Rodríguez, Maykel, Ko, Arthur, Miao, Zong, Kaminska, Dorota, Õunap, Kadri, Örd, Tiit, Ravindran, Aarthi, Liu, Oscar H., Moreau, Pierre R., Jawahar Deen, Ashik, Männistö, Ville, Pan, Calvin, Levonen, Anna-Liisa, Lusis, Aldons J., Heikkinen, Sami, Romanoski, Casey E., Pihlajamäki, Jussi, Pajukanta, Päivi, Kaikkonen, Minna U.

“…Genetic factors underlying coronary artery disease (CAD) have been widely studied using genome-wide association studies (GWASs). However, the functional…”
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Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease by Darci-Maher, Nicholas, Alvarez, Marcus, Arasu, Uma Thanigai, Selvarajan, Ilakya, Lee, Seung Hyuk T., Pan, David Z., Miao, Zong, Das, Sankha Subhra, Kaminska, Dorota, Örd, Tiit, Benhammou, Jihane N., Wabitsch, Martin, Pisegna, Joseph R., Männistö, Ville, Pietiläinen, Kirsi H., Laakso, Markku, Sinsheimer, Janet S., Kaikkonen, Minna U., Pihlajamäki, Jussi, Pajukanta, Päivi

“…Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose…”
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Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver diseaseResearch in context by Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T. Lee, David Z. Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N. Benhammou, Martin Wabitsch, Joseph R. Pisegna, Ville Männistö, Kirsi H. Pietiläinen, Markku Laakso, Janet S. Sinsheimer, Minna U. Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta

“…Background: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises…”
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Interaction modes at protein hetero-dimer interfaces by Vaishnavi, Ayyappan, Sowmya, Gopichandran, Kalaivanii, Jayaseelan, Ilakya, Selvarajan, Kangueane, Uma, Kangueane, Pandjassarame

“…Hetero dimer (different monomers) interfaces are involved in catalysis and regulation through the formation of interface active sites. This is critical in cell…”
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