Search Results - "Selsing, Erik"

Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors by Han, Jin-Hwan, Akira, Shizuo, Calame, Kathryn, Beutler, Bruce, Selsing, Erik, Imanishi-Kari, Thereza

“…Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic…”
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Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch Repair by Schrader, Carol E, Guikema, Jeroen E. J, Linehan, Erin K, Selsing, Erik, Stavnezer, Janet

“…Ab class switching occurs by an intrachromosomal recombination and requires generation of double-strand breaks (DSBs) in Ig switch (S) regions…”
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Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes by McDonald, Gabrielle, Medina, Carlos O, Pilichowska, Monika, Kearney, John F, Shinkura, Reiko, Selsing, Erik, Wortis, Henry H, Honjo, Tasuku, Imanishi-Kari, Thereza

“…564Igi mice have knocked-in immunoglobulin (Ig) heavy (H) and light (L) chain genes that encode an autoantibody recognizing RNA. Previously, we showed that…”
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Expression of an anti‐RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN‐I expression by Han, Jin‐Hwan, Umiker, Benjamin R., Kazimirova, Anastasia A., Fray, Michael, Korgaonkar, Parimal, Selsing, Erik, Imanishi‐Kari, Thereza

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of antinucleic acid autoantibodies, high levels of circulating type I…”
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Sequence Dependence of Chromosomal R-Loops at the Immunoglobulin Heavy-Chain Sμ Class Switch Region by Huang, Feng-Ting, Yu, Kefei, Balter, Barbara B., Selsing, Erik, Oruc, Zeliha, Khamlichi, Ahmed Amine, Hsieh, Chih-Lin, Lieber, Michael R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gene conversion–like sequence transfers in a mouse antibody transgene: antigen selection allows sensitive detection of V region interactions based on homology by Tsai, Hwei-Fang, D'Avirro, Nicole, Selsing, Erik

“…Gene conversion is important for antibody diversification in chickens, rabbits and cows. In mice, however, conversion events appear to be infrequent among…”
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Ig class switching: targeting the recombinational mechanism by Selsing, Erik

“…Recent studies have provided insights into the mechanisms involved in targeting antibody gene class switch recombination (CSR) to various switch DNA regions…”
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p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation by Shansab, Maryam, Selsing, Erik

“…In B cells, activation-induced cytidine deaminase (AID) induces somatic hypermutation (SHM) at rearranged immunoglobulin (Ig) variable (V) regions. Previous…”
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S-S Synapsis during Class Switch Recombination Is Promoted by Distantly Located Transcriptional Elements and Activation-Induced Deaminase by Wuerffel, Robert, Wang, Lili, Grigera, Fernando, Manis, John, Selsing, Erik, Perlot, Thomas, Alt, Frederick W., Cogne, Michel, Pinaud, Eric, Kenter, Amy L.

“…Molecular mechanisms underlying synapsis of activation-induced deaminase (AID)-targeted S regions during class switch recombination (CSR) are poorly…”
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Recombination between immunoglobulin variable region gene segments is enhanced by transcription by Blackwell, T. Keith, Moore, Mark W, Yancopoulos, George D, Suh, Heikyung, Lutzker, Stuart, Selsing, Erik, Alt, Frederick W

“…Immunoglobulin (Ig) variable (V) region genes are assembled in precursor B (pre-B) lymphocytes from multiple germline segments. The heavy-chain V-region gene…”
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Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining by Eccleston, Jennifer, Yan, Catherine, Yuan, Karen, Alt, Frederick W, Selsing, Erik

“…In the absence of core nonhomologous end-joining (NHEJ) factors, Ab gene class-switch recombination (CSR) uses an alternative end-joining (A-EJ) pathway to…”
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Somatic mutation of immunoglobulin light-chain variable-region genes by Selsing, E, Storb, U

“…A single germline immunoglobulin kappa-variable-region gene, VK167, is rearranged and expressed in two myelomas, MOPC167 and MOPC511. Only this single germline…”
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Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region by Shansab, Maryam, Eccleston, Jennifer M., Selsing, Erik

“…Immunoglobulin (Ig) class switch recombination (CSR) occurs most often by intrachromosomal recombinations between switch (S) regions located on a single…”
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Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats by Eccleston, Jennifer, Schrader, Carol E, Yuan, Karen, Stavnezer, Janet, Selsing, Erik

“…The Msh2 mismatch repair (MMR) protein is critical for class switch recombination (CSR) events that occur in mice that lack the Smu tandem repeat (SmuTR)…”
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Expression of an anti-RNA autoantibody in a mouse model of SLE is sufficient to increase neutrophil and monocyte numbers as well as the amount of IFN-I by Han, Jin-Hwan, Umiker, Benjamin R., Kazimirova, Anastasia A., Fray, Michael, Korgaonkar, Parimal, Selsing, Erik, Imanishi-Kari, Thereza

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of anti-nucleic acid autoantibodies, high levels of circulating type…”
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Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations by Balter, Barbara B., Ciccone, David N., Oettinger, Marjorie A., Selsing, Erik

“…► Histone H3 acetylation and trimethylation mark CSR accessible regions in B cells. ► Sμ histone H3 marks depend on flanking but not underlying DNA sequences…”
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Mice lacking SI14 tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations by Balter, Barbara B, Ciccone, David N, Oettinger, Marjorie A, Selsing, Erik

“…Antibody switching involves class switch recombination (CSR) events between switch (S) regions located upstream of heavy chain constant (C) genes. Mechanisms…”
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Mismatch repair proteins, MSH2, MLH1 and EXO1 are important for class switch recombination events occurring in B cells that lack non-homologous end joining by Eccleston, Jennifer, Yan, Catherine, Yuan, Karen, Alt, Frederick W., Selsing, Erik

“…In the absence of core nonhomologous end-joining (NHEJ) factors, antibody gene class switch recombination (CSR) uses an alternative-end joining (A-EJ) pathway…”
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Class Switch Recombination Efficiency and Junction Microhomology Patterns in Msh2-, Mlh1-, and Exo1-Deficient Mice Depend on the Presence of μ Switch Region Tandem Repeats1 by Eccleston, Jennifer, Schrader, Carol E., Yuan, Karen, Stavnezer, Janet, Selsing, Erik

“…The Msh2 mismatch repair (MMR) protein is critical for class switch recombination (CSR) events that occur in mice that lack the S μ tandem repeat (S μ TR)…”
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The mu switch region tandem repeats are important, but not required, for antibody class switch recombination by Luby, T M, Schrader, C E, Stavnezer, J, Selsing, E

“…Class switch DNA recombinations change the constant (C) region of the antibody heavy (H) chain expressed by a B cell and thereby change the antibody effector…”
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