Search Results - "Selnick, H. G."

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase by Liverton, Nigel J, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Libby, Brian E, Nguyen, Kevin T, Pitzenberger, Steven M, Selnick, Harold G, Smith, Garry R, Tebben, Andrew, Vacca, Joseph P, Varga, Sandor L, Agarwal, Lily, Dancheck, Kim, Forsyth, Amy J, Fletcher, Daniel S, Frantz, Betsy, Hanlon, William A, Harper, Coral F, Hofsess, Scott J, Kostura, Matthew, Lin, Jiunn, Luell, Sylvie, O'Neill, Edward A, Orevillo, Chad J, Pang, Margaret, Parsons, Janey, Rolando, Anna, Sahly, Yousif, Visco, Denise M, O'Keefe, Stephen J

“…Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays…”
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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia by Barrow, J C, Nantermet, P G, Selnick, H G, Glass, K L, Rittle, K E, Gilbert, K F, Steele, T G, Homnick, C F, Freidinger, R M, Ransom, R W, Kling, P, Reiss, D, Broten, T P, Schorn, T W, Chang, R S, O'Malley, S S, Olah, T V, Ellis, J D, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C

“…alpha(1) Adrenergic receptors mediate both vascular and lower urinary tract tone, and alpha(1) receptor antagonists such as terazosin (1b) are used to treat…”
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Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle by Baskin, E P, Serik, C M, Wallace, A A, Brookes, L M, Selnick, H G, Claremon, D A, Lynch, Jr, J J

“…The effects of the new and potent methanesulfonanilide class III antiarrhythmic agents (E-4031, UK-66,914, and UK-68,798) on myocardial refractoriness and…”
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Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs by Wallace, A A, Stupienski, 3rd, R F, Brookes, L M, Selnick, H G, Claremon, D A, Lynch, Jr, J J

“…The effects of cumulative intravenous (i.v.) administration of potent and selective methanesulfonanilide class III antiarrhythmic agents on cardiac…”
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Suppression of lethal ischemic ventricular arrhythmias by the class III agent E4031 in a canine model of previous myocardial infarction by Lynch, Jr, J J, Heaney, L A, Wallace, A A, Gehret, J R, Selnick, H G, Stein, R B

“…The antiarrhythmic efficacy of a new and potent class III agent E4031 [1-[2-(6-methyl-2-pyridyl)-ethyl]-4-(4- methylsulfonylaminobenzoyl)piperidine] was…”
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A short radiosynthesis of 6-[C3H3]-dorzolamide at very high specific activity and optical purity by Eng, W.-s., Burns, H. D., Ponticello, G. S., Selnick, H. G.

“…6‐[C3H3]‐Dorzolamide was prepared starting from N, N′‐bis‐Boc‐6‐desmethyl‐dorzolamide. An efficient radiosynthesis was developed involving a regioselective and…”
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Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists by Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Ngo, Phung L, Young, Mary Beth, Pellicore, Janetta M, Breslin, Michael J, Hutchinson, John H, Freidinger, Roger M, Condra, Cindra, Karczewski, Jerzy, Bednar, Rodney A, Gaul, Stanley L, Stern, Andrew, Gould, Robert, Connolly, Thomas M

“…Thrombin is the most potent agonist of platelet activation, and its effects are predominantly mediated by platelet thrombin receptors. Therefore, antagonists…”
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The total synthesis of avermectin A1a by Danishefsky, Samuel J, Armistead, David M, Wincott, Francine E, Selnick, Harold G, Hungate, Randall

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Total synthesis of (.+-.)-gnididione and (.+-.)-isognididione by Jacobi, Peter A, Selnick, Harold G

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Total synthesis of zincophorin by Danishefsky, Samuel J, Selnick, Harold G, Zelle, Robert E, DeNinno, Michael P

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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide by SELNICK, Harold G., LIVERTON, Nigel J., BALDWIN, John J., BUTCHER, John W., CLAREMON, David A., ELLIOTT, Jason M., FREIDINGER, Roger M., KING, Stella A., LIBBY, Brian E., MCINTYRE, Charles J., PRIBUSH, David A., REMY, David C., SMITH, Garry R., TEBBEN, Andrew J., JURKIEWICZ, Nancy K., LYNCH, Joseph J., SALATA, Joseph J., SANGUINETTI, Michael C., SIEGL, Peter K. S., SLAUGHTER, Donald E., VYAS, Kamlesh

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The total synthesis of the aglycon of avermectin A1a by Danishefsky, Samuel J, Armistead, David M, Wincott, Francine E, Selnick, Harold G, Hungate, Randall

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The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosides by Danishefsky, Samuel J, Selnick, Harold G, Armistead, David M, Wincott, Francine E

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Non-peptidic small-molecule antagonists of the human platelet thrombin receptor PAR-1 by Selnick, H G, Barrow, J C, Nantermet, P G, Connolly, T M

“…The thrombin receptor on human platelets is the first member identified of a new family of G-protein coupled receptors referred to as protease activated…”
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The total synthesis of zincophorin by Danishefsky, Samuel J, Selnick, Harold G, DeNinno, Michael P, Zelle, Robert E

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A systematic degradation of zincophorin: a stereoselective synthesis of the C17-C25 fragment by Zelle, Robert E, DeNinno, Michael P, Selnick, Harold G, Danishefsky, Samuel J

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Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia by Lynch, Jr, J J, Houle, M S, Stump, G L, Wallace, A A, Gilberto, D B, Jahansouz, H, Smith, G R, Tebben, A J, Liverton, N J, Selnick, H G, Claremon, D A, Billman, G E

“…To date, the lack of potent and selective inhibitors has hampered the physiological assessment of modulation of the cardiac slowly activating delayed rectifier…”
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Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors by Young, Mary Beth, Barrow, James C., Glass, Kristen L., Lundell, George F., Newton, Christina L., Pellicore, Janetta M., Rittle, Kenneth E., Selnick, Harold G., Stauffer, Kenneth J., Vacca, Joseph P., Williams, Peter D., Bohn, Dennis, Clayton, Franklin C., Cook, Jacquelynn J., Krueger, Julie A., Kuo, Lawrence C., Lewis, S. Dale, Lucas, Bobby J., McMasters, Daniel R., Miller-Stein, Cynthia, Pietrak, Beth L., Wallace, Audrey A., White, Rebecca B., Wong, Bradley, Yan, Youwei, Nantermet, Philippe G.

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Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists by Barrow, J C, Glass, K L, Selnick, H G, Freidinger, R M, Chang, R S, O'Malley, S S, Woyden, C

“…Several 1,3-diaminocyclopentane linked alpha1a-receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all…”
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A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide by Barrow, James C, Ngo, Phung L, Pellicore, Janetta M, Selnick, Harold G, Nantermet, Philippe G

“…Addition of organometallic reagents to tert-butylsulfinimines derived from tert-butyldimethylsiloxyacetaldehyde stereoselectively generates protected 1,2-amino…”
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