Search Results - "Sellin, Lorenz"

Circulating Permeability Factors in Primary Focal Segmental Glomerulosclerosis: A Review of Proposed Candidates by Königshausen, Eva, Sellin, Lorenz

“…Primary focal segmental glomerulosclerosis (FSGS) is a major cause of the nephrotic syndrome and often leads to end-stage renal disease. This review focuses on…”
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Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria by Woznowski, Magdalena Patrycja, Potthoff, Sebastian Alexander, Königshausen, Eva, Haase, Raphael, Hoch, Henning, Meyer-Schwesinger, Catherine, Wiech, Thorsten, Stegbauer, Johannes, Rump, Lars Christian, Sellin, Lorenz, Quack, Ivo

“…Chronic hyperglycemia, as in diabetes mellitus, may cause glomerular damage with microalbuminuria as an early sign. Noteworthy, even acute hyperglycemia can…”
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A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis by Trachtman, Howard, Fervenza, Fernando C., Gipson, Debbie S., Heering, Peter, Jayne, David R.W., Peters, Harm, Rota, Stefano, Remuzzi, Giuseppe, Rump, L. Christian, Sellin, Lorenz K., Heaton, Jeremy P.W., Streisand, James B., Hard, Marjie L., Ledbetter, Steven R., Vincenti, Flavio

“…Primary focal segmental glomerulosclerosis (FSGS) is a disease with poor prognosis and high unmet therapeutic need. Here, we evaluated the safety and…”
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Recent Treatment Advances and New Trials in Adult Nephrotic Syndrome by Königshausen, Eva, Sellin, Lorenz

“…The etiology of nephrotic syndrome is complex and ranges from primary glomerulonephritis to secondary forms. Patients with nephrotic syndrome often need…”
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Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury by Randles, Michael J., Collinson, Sophie, Starborg, Tobias, Mironov, Aleksandr, Krendel, Mira, Königshausen, Eva, Sellin, Lorenz, Roberts, Ian S. D., Kadler, Karl E., Miner, Jeffrey H., Lennon, Rachel

“…Glomeruli are highly sophisticated filters and glomerular disease is the leading cause of kidney failure. Morphological change in glomerular podocytes and the…”
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Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells by Neuwahl, Judith, Neumann, Chantal A., Fitz, Annika C., Biermann, Anica D., Magel, Maja, Friedrich, Annabelle, Sellin, Lorenz, Stork, Björn, Piekorz, Roland P., Proksch, Peter, Budach, Wilfried, Jänicke, Reiner U., Sohn, Dennis

“…The targeted elimination of radio- or chemotherapy-induced senescent cells by so-called senolytic substances represents a promising approach to reduce tumor…”
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A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis by Vincenti, Flavio, Fervenza, Fernando C, Campbell, Kirk N, Diaz, Montserrat, Gesualdo, Loreto, Nelson, Peter, Praga, Manuel, Radhakrishnan, Jai, Sellin, Lorenz, Singh, Ajay, Thornley-Brown, Denyse, Veronese, Francisco Veríssimo, Accomando, Beverly, Engstrand, Sara, Ledbetter, Steven, Lin, Julie, Neylan, John, Tumlin, James

“…Steroid-resistant focal segmental glomerulosclerosis (SR-FSGS) is a common glomerulopathy associated with nephrotic range proteinuria. Treatment goals are…”
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Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin by Lüke, Yvonne, Zaim, Hafida, Karakesisoglou, Iakowos, Jaeger, Verena M, Sellin, Lorenz, Lu, Wenshu, Schneider, Maria, Neumann, Sascha, Beijer, Asa, Munck, Martina, Padmakumar, V.C, Gloy, Joachim, Walz, Gerd, Noegel, Angelika A

“…Giant isoforms, encoded by Nesprin-1 (Syne1) and Nesprin-2 (Syne2), are multifunctional actin-binding and nuclear-envelope-associated proteins belonging to the…”
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A novel in vivo method to quantify slit diaphragm protein abundance in murine proteinuric kidney disease by Haase, Raphael, Potthoff, Sebastian Alexander, Meyer-Schwesinger, Catherine, Frosch, Clara, Wiech, Thorsten, Panzer, Ulf, Königshausen, Eva, Stegbauer, Johannes, Sellin, Lorenz, Rump, Lars Christian, Quack, Ivo, Woznowski, Magdalena

“…Injury of the glomerular filter causes proteinuria by disrupting the sensitive interplay of the glomerular protein network. To date, studies of the expression…”
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β-Arrestin2 Mediates Nephrin Endocytosis and Impairs Slit Diaphragm Integrity by Quack, Ivo, Rump, L. Christian, Gerke, Peter, Walther, Inga, Vinke, Tobias, Vonend, Oliver, Grunwald, Thomas, Sellin, Lorenz

“…β-Arrestins mediate internalization of plasma membrane receptors. Nephrin, a structural component of the glomerular slit diaphragm, is a single transmembrane…”
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Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1 by GERKE, Peter, HUBER, Tobias B, SELLIN, Lorenz, BENZING, Thomas, WALZ, Gerd

“…Nephrin and NEPH1, the gene products of NPHS1 and NEPH1, are podocyte membrane proteins of the Ig superfamily. Similar to the nephrin knockout, mice lacking…”
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Combination therapy for hypertension: focus on high-dose olmesartan medoxomil (40 mg) plus hydrochlorothiazide by Rump, Lars Christian, Sellin, Lorenz

“…Cardiovascular disease is a major cause of premature death and disability worldwide, and effective blood pressure (BP) control is crucial for the reduction of…”
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The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing by Rashmi, R.N., Eckes, Beate, Glöckner, Gernot, Groth, Marco, Neumann, Sascha, Gloy, Joachim, Sellin, Lorenz, Walz, Gerd, Schneider, Maria, Karakesisoglou, Iakowos, Eichinger, Ludwig, Noegel, Angelika A.

“…Nesprin-2, a type II transmembrane protein of the nuclear envelope, is a component of the LINC complex that connects the nuclear lamina with the actin…”
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The Carboxyl Terminus of Neph Family Members Binds to the PDZ Domain Protein Zonula Occludens-1 by Huber, Tobias B, Schmidts, Miriam, Gerke, Peter, Schermer, Bernhard, Zahn, Anne, Hartleben, Björn, Sellin, Lorenz, Walz, Gerd, Benzing, Thomas

“…The PSD95/Dlg/ZO-1 (PDZ) domain-containing protein zonula occludens-1 (ZO-1) selectively localizes to the cytoplasmic basis of the slit diaphragm, a…”
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Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release by Stegbauer, Johannes, Kuczka, Yvonne, Vonend, Oliver, Quack, Ivo, Sellin, Lorenz, Patzak, Andreas, Steege, Andreas, Langnaese, Kristina, Rump, Lars Christian

“…Nitric oxide (NO) is mainly generated by endothelial NO synthase (eNOS) or neuronal NOS (nNOS). Recent studies indicate that angiotensin II generates NO…”
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Eosinophilic gastroenteritis in a young girl--long term remission under Montelukast by Quack, Ivo, Sellin, Lorenz, Buchner, Nikolaus J, Theegarten, Dirk, Rump, Lars C, Henning, Bernhard F

“…Eosinophilic gastrointestinal disorders are an emerging disease entity characterized by eosinophilic infiltration of the intestinal wall. Oral steroids can be…”
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A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum by Gao, Hongyu, Sellin, Lorenz K., Pütz, Michael, Nickel, Christian, Imgrund, Michael, Gerke, Peter, Nitschke, Roland, Walz, Gerd, Kramer-Zucker, Albrecht G.

“…Mutations of PKD1 cause autosomal dominant polycystic kidney disease (ADPKD), a syndrome characterized by kidney cysts and progressive renal failure…”
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Interaction between RGS7 and Polycystin by Kim, Emily, Arnould, Thierry, Sellin, Lorenz, Benzing, Thomas, Comella, Natalia, Kocher, Olivier, Tsiokas, Leonidas, Sukhatme, Vikas P., Walz, Gerd

“…Regulators of G protein signaling (RGS) proteins accelerate the intrinsic GTPase activity of certain Gα subunits and thereby modulate a number of G…”
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14-3-3 Interacts with Regulator of G Protein Signaling Proteins and Modulates Their Activity by Benzing, T, Yaffe, M B, Arnould, T, Sellin, L, Schermer, B, Schilling, B, Schreiber, R, Kunzelmann, K, Leparc, G G, Kim, E, Walz, G

“…Regulator of G protein signaling (RGS) proteins function as GTPase-activating proteins (GAPs) that stimulate the inactivation of heterotrimeric G proteins. We…”
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Protein 4.1O Binds to Polycystin-1, Activates Ubiquitination, and Inhibits Polycystin-1 Signaling: FR-PO274 by Vienken, Theresia, Koenigshausen, Eva, Rump, Lars C., Sellin, Lorenz

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