Search Results - "Sellin, Karine"
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PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
Published in Cancer discovery (01-07-2021)“…Pancreatic cancer metastasis is a leading cause of cancer-related deaths, yet very little is understood regarding the underlying biology. As a result, targeted…”
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Parathyroid Hormone‐Related Protein Inhibition Blocks Triple‐Negative Breast Cancer Expansion in Bone Through Epithelial to Mesenchymal Transition Reversal
Published in JBMR plus (01-06-2022)“…ABSTRACT Parathyroid hormone‐related protein (PTHrP) plays a major role in skeletal metastasis but its action mechanism has not been fully defined. We…”
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Bril: A Novel Bone‐Specific Modulator of Mineralization
Published in Journal of bone and mineral research (01-09-2008)“…In the course of attempting to define the bone “secretome” using a signal‐trap screening approach, we identified a gene encoding a small membrane protein novel…”
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Osteocrin Is a Specific Ligand of the Natriuretic Peptide Clearance Receptor That Modulates Bone Growth
Published in The Journal of biological chemistry (14-12-2007)“…Osteocrin (Ostn) is a recently discovered secreted protein produced by cells of the osteoblast lineage that shows a well conserved homology with members of the…”
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Abstract 520: Therapeutic antibodies against parathyroid hormone-related peptide (PTHrP) inhibit the growth of established skeletal metastasis in mice transplanted with human triple negative breast cancer cell lines
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract Parathyroid Hormone-related Peptide (PTHrP)is a potent regulator of bone turnover and is thought to play a major role in the progression of skeletal…”
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Abstract 3062: Ablation of parathyroid hormone-related protein in the triple negative human breast cancer line MDA-MB-231 inhibits its cancer stem cell phenotype
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Parathyroid hormone-related protein (PTHrP) is a pleiotropic hormone involved in a wide range of developmental & physiological processes. It is also…”
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Gene expression profiling and histomorphometric analyses of the early bone healing response around nanotextured implants
Published in Nanomedicine (London, England) (01-09-2013)“…While in vitro studies have shown that nanoscale surface modifications influence cell fate and activity, there is little information on how they modulate…”
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Ameloblastin is not implicated in bone remodelling and repair
Published in European cells & materials (15-07-2011)“…Ameloblastin (AMBN) is an enamel matrix protein produced by ameloblasts. It has been suggested that AMBN might also be implicated in craniofacial bone…”
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