Search Results - "Selle, Kurt"

CRISPR-based screening of genomic island excision events in bacteria by Selle, Kurt, Todd R. Klaenhammer, Rodolphe Barrangou

“…Genomic analysis of Streptococcus thermophilus revealed that mobile genetic elements (MGEs) likely contributed to gene acquisition and loss during evolutionary…”
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Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM by Johnson, Brant, Selle, Kurt, O'Flaherty, Sarah, Goh, Yong Jun, Klaenhammer, Todd

“…Bacterial surface (S-) layers are crystalline arrays of self-assembling, proteinaceous subunits called S-layer proteins (Slps), with molecular masses ranging…”
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Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems by Gomaa, Ahmed A, Klumpe, Heidi E, Luo, Michelle L, Selle, Kurt, Barrangou, Rodolphe, Beisel, Chase L

“…CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems in bacteria and archaea employ CRISPR RNAs to specifically…”
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Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri by Sanozky-Dawes, Rosemary, Selle, Kurt, O'Flaherty, Sarah, Klaenhammer, Todd, Barrangou, Rodolphe

“…Bacteria encode clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated genes (cas), which collectively form an RNA-guided…”
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Harnessing CRISPR–Cas systems for bacterial genome editing by Selle, Kurt, Barrangou, Rodolphe

“…Highlights • CRISPR–Cas provides DNA-encoded, RNA-mediated sequence-specific targeting of DNA. • The Cas9 endonuclease can be reprogrammed to cleave DNA…”
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Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid by Zadeh, Mojgan, Khan, Mohammad W, Goh, Yong Jun, Selle, Kurt, Owen, Jennifer L, Klaenhammer, Todd, Mohamadzadeh, Mansour

“…The cellular and molecular mechanisms of inflammatory bowel disease are not fully understood; however, data indicate that uncontrolled chronic inflammation…”
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CRISPR-Based Technologies and the Future of Food Science by Selle, Kurt, Barrangou, Rodolphe

“…The on‐going CRISPR craze is focused on the use of Cas9‐based technologies for genome editing applications in eukaryotes, with high potential for translational…”
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Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health by Selle, Kurt, Klaenhammer, Todd R.

“…Abstract Certain lactic acid bacteria (LAB) have the capacity to occupy mucosal niches of humans, including the oral cavity, gastrointestinal tract, and…”
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Applications of designer phage encoding recombinant gene payloads by Schmitt, Daniel S., Siegel, Sara D., Selle, Kurt

“…Phage therapy has traditionally focused on the utility of phages in eliminating bacteria in the context of infectious disease, but new potential applications…”
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Outcomes and characterization of chromosomal self-targeting by native CRISPR-Cas systems in Streptococcus thermophilus by Cañez, Cassandra, Selle, Kurt, Goh, Yong Jun, Barrangou, Rodolphe

“…CRISPR-Cas systems provide adaptive immunity against phages in prokaryotes via DNA-encoded, RNA-mediated, nuclease-dependent targeting and cleavage. Due to…”
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In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials by Selle, Kurt, Fletcher, Joshua R, Tuson, Hannah, Schmitt, Daniel S, McMillan, Lana, Vridhambal, Gowrinarayani S, Rivera, Alissa J, Montgomery, Stephanie A, Fortier, Louis-Charles, Barrangou, Rodolphe, Theriot, Casey M, Ousterout, David G

“…is an important nosocomial pathogen that causes approximately 500,000 cases of infection (CDI) and 29,000 deaths annually in the United States. Antibiotic use…”
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Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality by Briner, Alexandra E., Donohoue, Paul D., Gomaa, Ahmed A., Selle, Kurt, Slorach, Euan M., Nye, Christopher H., Haurwitz, Rachel E., Beisel, Chase L., May, Andrew P., Barrangou, Rodolphe

“…The RNA-guided Cas9 endonuclease specifically targets and cleaves DNA in a sequence-dependent manner and has been widely used for programmable genome editing…”
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SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis by Lightfoot, Yaíma L, Selle, Kurt, Yang, Tao, Goh, Yong Jun, Sahay, Bikash, Zadeh, Mojgan, Owen, Jennifer L, Colliou, Natacha, Li, Eric, Johannssen, Timo, Lepenies, Bernd, Klaenhammer, Todd R, Mohamadzadeh, Mansour

“…Intestinal immune regulatory signals govern gut homeostasis. Breakdown of such regulatory mechanisms may result in inflammatory bowel disease (IBD)…”
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Sortase-deficient lactobacilli: effect on immunomodulation and gut retention by Call, Emma K, Goh, Yong Jun, Selle, Kurt, Klaenhammer, Todd R, O'Flaherty, Sarah

“…Surface proteins of probiotic microbes, including Lactobacillus acidophilus and Lactobacillus gasseri, are believed to promote retention in the gut and mediate…”
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Sortase-deficient lactobacilli: effect on immunomodulation and gut retention by Call, Emma K., Goh, Yong Jun, Selle, Kurt, Klaenhammer, Todd R., O’Flaherty, Sarah

“…Surface proteins of probiotic microbes, including Lactobacillus acidophilus and Lactobacillus gasseri , are believed to promote retention in the gut and…”
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Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus by Selle, Kurt, Goh, Yong J, Johnson, Brant R, O'Flaherty, Sarah, Andersen, Joakim M, Barrangou, Rodolphe, Klaenhammer, Todd R

“…NCFM is a well-characterized probiotic microorganism, supported by a decade of genomic and functional phenotypic investigations. deficient in lipoteichoic acid…”
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Digital Twins in Pilot Scale Fermentation: Non-Linear State Estimation for Improving Induction Timing by Stevnsborg, Mads, Selle, Kurt, Barton, Ryan, Prado-Rubio, Oscar A., Gargalo, Carina, Gernaey, Krist V., Gilleskie, Gary, Huusom, Jakob K.

“…In this work, a model is developed and implemented for GFPUV production with aerobic fed-batch fermentation of E coli BL21 (DE3). The model parameters are…”
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Development of an integration mutagenesis system in Lactobacillus gasseri by Selle, Kurt, Goh, Yong Jun, O'Flaherty, Sarah, Klaenhammer, Todd R

“…Lactobacillus gasseri ATCC 33323 is a member of the acidophilus-complex group, microbes of human origin with significant potential for impacting human health…”
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SIGNR 3‐dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis by Lightfoot, Yaíma L, Selle, Kurt, Yang, Tao, Goh, Yong Jun, Sahay, Bikash, Zadeh, Mojgan, Owen, Jennifer L, Colliou, Natacha, Li, Eric, Johannssen, Timo, Lepenies, Bernd, Klaenhammer, Todd R, Mohamadzadeh, Mansour

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italic toggle="yes">In Vivo /italic> Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials by Kurt Selle, Joshua R. Fletcher, Hannah Tuson, Daniel S. Schmitt, Lana McMillan, Gowrinarayani S. Vridhambal, Alissa J. Rivera, Stephanie A. Montgomery, Louis-Charles Fortier, Rodolphe Barrangou, Casey M. Theriot, David G. Ousterout

“…ABSTRACT Clostridioides difficile is an important nosocomial pathogen that causes approximately 500,000 cases of C. difficile infection (CDI) and 29,000 deaths…”
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