Search Results - "Sella, Guy"

Thinking About the Evolution of Complex Traits in the Era of Genome-Wide Association Studies by Sella, Guy, Barton, Nicholas H

“…Many traits of interest are highly heritable and genetically complex, meaning that much of the variation they exhibit arises from differences at numerous loci…”
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Life history effects on the molecular clock of autosomes and sex chromosomes by Amster, Guy, Sella, Guy

“…One of the foundational results in molecular evolution is that the rate at which neutral substitutions accumulate on a lineage equals the rate at which…”
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Polygenic adaptation after a sudden change in environment by Hayward, Laura Katharine, Sella, Guy

“…Polygenic adaptation is thought to be ubiquitous, yet remains poorly understood. Here, we model this process analytically, in the plausible setting of a highly…”
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The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives by Simons, Yuval B, Sella, Guy

“…Over the past decade, there has been both great interest and confusion about whether recent demographic events — notably the Out-of-Africa-bottleneck and…”
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Measuring intolerance to mutation in human genetics by Fuller, Zachary L., Berg, Jeremy J., Mostafavi, Hakhamanesh, Sella, Guy, Przeworski, Molly

“…In numerous applications, from working with animal models to mapping the genetic basis of human disease susceptibility, knowing whether a single disrupting…”
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A population genetic interpretation of GWAS findings for human quantitative traits by Simons, Yuval B, Bullaughey, Kevin, Hudson, Richard R, Sella, Guy

“…Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect…”
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Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence by Baker, Zachary, Przeworski, Molly, Sella, Guy

“…In many species, meiotic recombination events tend to occur in narrow intervals of the genome, known as hotspots. In humans and mice, double strand break (DSB)…”
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The deleterious mutation load is insensitive to recent population history by Simons, Yuval B, Turchin, Michael C, Pritchard, Jonathan K, Sella, Guy

“…Jonathan Pritchard, Guy Sella and colleagues report an analysis using population genetic models to show that recent human demography is likely to have had…”
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Interpreting the Dependence of Mutation Rates on Age and Time by Gao, Ziyue, Wyman, Minyoung J, Sella, Guy, Przeworski, Molly

“…Mutations can originate from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that arise between replication cycles and…”
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A Genomic Map of the Effects of Linked Selection in Drosophila by Elyashiv, Eyal, Sattath, Shmuel, Hu, Tina T, Strutsovsky, Alon, McVicker, Graham, Andolfatto, Peter, Coop, Graham, Sella, Guy

“…Natural selection at one site shapes patterns of genetic variation at linked sites. Quantifying the effects of "linked selection" on levels of genetic…”
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Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements by Murphy, David A, Elyashiv, Eyal, Amster, Guy, Sella, Guy

“…Analyses of genetic variation in many taxa have established that neutral genetic diversity is shaped by natural selection at linked sites. Whether the mode of…”
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Pervasive natural selection in the Drosophila genome? by Sella, Guy, Petrov, Dmitri A, Przeworski, Molly, Andolfatto, Peter

“…Over the past four decades, the predominant view of molecular evolution saw little connection between natural selection and genome evolution, assuming that the…”
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ABO blood group is a trans-species polymorphism in primates by Ségurel, Laure, Thompson, Emma E, Flutre, Timothée, Lovstad, Jessica, Venkat, Aarti, Margulis, Susan W, Moyse, Jill, Ross, Steve, Gamble, Kathryn, Sella, Guy, Ober, Carole, Przeworski, Molly

“…The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO…”
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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees by Leffler, Ellen M., Gao, Ziyue, Pfeifer, Susanne, Ségurel, Laure, Auton, Adam, Venn, Oliver, Bowden, Rory, Bontrop, Ronald, Wall, Jeffrey D., Sella, Guy, Donnelly, Peter, McVean, Gilean, Przeworski, Molly

“…Instances in which natural selection maintains genetic variation in a population over millions of years are thought to be extremely rare. We conducted a…”
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Pervasive adaptive protein evolution apparent in diversity patterns around amino acid substitutions in Drosophila simulans by Sattath, Shmuel, Elyashiv, Eyal, Kolodny, Oren, Rinott, Yosef, Sella, Guy

“…In Drosophila, multiple lines of evidence converge in suggesting that beneficial substitutions to the genome may be common. All suffer from confounding…”
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Impact of essential workers in the context of social distancing for epidemic control by Milligan, William R, Fuller, Zachary L, Agarwal, Ipsita, Eisen, Michael B, Przeworski, Molly, Sella, Guy

“…New emerging infectious diseases are identified every year, a subset of which become global pandemics like COVID-19. In the case of COVID-19, many governments…”
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The Application of Statistical Physics to Evolutionary Biology by Sella, Guy, Hirsh, Aaron E., Levin, Simon A.

“…A number of fundamental mathematical models of the evolutionary process exhibit dynamics that can be difficult to understand analytically. Here we show that a…”
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Shifts in the intensity of purifying selection: an analysis of genome-wide polymorphism data from two closely related yeast species by Elyashiv, Eyal, Bullaughey, Kevin, Sattath, Shmuel, Rinott, Yosef, Przeworski, Molly, Sella, Guy

“…How much does the intensity of purifying selection vary among populations and species? How uniform are the shifts in selective pressures across the genome? To…”
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Pervasive hitchhiking at coding and regulatory sites in humans by Cai, James J, Macpherson, J Michael, Sella, Guy, Petrov, Dmitri A

“…Much effort and interest have focused on assessing the importance of natural selection, particularly positive natural selection, in shaping the human genome…”
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Life History Effects on Neutral Diversity Levels of Autosomes and Sex Chromosomes by Amster, Guy, Sella, Guy

“…Abstract Understanding the determinants of neutral diversity patterns on autosomes and sex chromosomes provides a bedrock for our interpretation of population…”
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