Search Results - "Selkoe, Dennis J."

Treatments for Alzheimer's disease emerge by Selkoe, Dennis J.

“…Anti-amyloid immunotherapies will provide the first disease-modifying therapeutics Few of life's experiences evoke greater apprehension than a diagnosis of…”
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The amyloid hypothesis of Alzheimer's disease at 25 years by Selkoe, Dennis J, Hardy, John

“…Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that…”
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Preventing Alzheimer's Disease by Selkoe, Dennis J.

“…Despite intensive laboratory and clinical research over three decades, an effective treatment to delay the onset and progression of Alzheimer's disease is not…”
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Early network dysfunction in Alzheimer's disease by Selkoe, Dennis J

“…Small aggregates of β-amyloid peptide can hyperactivate neurons, which compromises neural networks Aggregation of the β-amyloid peptide (Aβ) in brain regions…”
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A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration by Walsh, Dominic M., Selkoe, Dennis J.

“…There has been a surge in the number of papers discussing the idea that inter-neuronal spread of 'pathogenic' proteins contributes to neurodegenerative disease…”
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Complement and microglia mediate early synapse loss in Alzheimer mouse models by Hong, Soyon, Beja-Glasser, Victoria F., Nfonoyim, Bianca M., Frouin, Arnaud, Li, Shaomin, Ramakrishnan, Saranya, Merry, Katherine M., Shi, Qiaoqiao, Rosenthal, Arnon, Barres, Ben A., Lemere, Cynthia A., Selkoe, Dennis J., Stevens, Beth

“…Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to…”
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The therapeutics of Alzheimer's disease: Where we stand and where we are heading by Selkoe, Dennis J.

“…Few diagnoses in modern medicine evoke more apprehension in patients and their families than Alzheimer disease (AD). Defined as a clinical and pathological…”
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Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration by Jin, Ming, Shepardson, Nina, Yang, Ting, Chen, Gang, Walsh, Dominic, Selkoe, Dennis J., Petsko, Gregory A.

“…Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more subtle process accounts for many cases of mild memory symptoms…”
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Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases by Selkoe, Dennis J

“…The salutary intersection of fundamental cell biology with the study of disease is well illustrated by the emerging elucidation of neurodegenerative disorders…”
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Alzheimer's Disease Is a Synaptic Failure by Selkoe, Dennis J.

“…In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this…”
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SnapShot: Pathobiology of Alzheimer's Disease by Selkoe, Dennis J.

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Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers by Li, Shaomin, Jin, Ming, Zhang, Dainan, Yang, Ting, Koeglsperger, Thomas, Fu, Hongjun, Selkoe, Dennis J.

“…A central question about human brain aging is whether cognitive enrichment slows the development of Alzheimer changes. Here, we show that prolonged exposure to…”
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Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes by Hong, Soyon, Ostaszewski, Beth L., Yang, Ting, O’Malley, Tiernan T., Jin, Ming, Yanagisawa, Katsuhiko, Li, Shaomin, Bartels, Tim, Selkoe, Dennis J.

“…Soluble Aβ oligomers contribute importantly to synaptotoxicity in Alzheimer’s disease, but their dynamics in vivo remain unclear. Here, we found that soluble…”
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Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain by Bolduc, David M., Montagna, Daniel R., Gu, Yongli, Selkoe, Dennis J., Wolfe, Michael S.

“…γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by shedding…”
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The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking by Meissner, Cathrin, Lorenz, Holger, Weihofen, Andreas, Selkoe, Dennis J., Lemberg, Marius K.

“…J. Neurochem. (2011) 117, 856–867. Intramembrane proteolysis is a conserved mechanism that regulates a variety of cellular processes ranging from transcription…”
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miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients by Cha, Diana J, Mengel, David, Mustapic, Maja, Liu, Wen, Selkoe, Dennis J, Kapogiannis, Dimitrios, Galasko, Douglas, Rissman, Robert A, Bennett, David A, Walsh, Dominic M

“…It was recently discovered that brain cells release extracellular vesicles (EV) which can pass from brain into blood. These findings raise the possibility that…”
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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons by Muratore, Christina R, Rice, Heather C, Srikanth, Priya, Callahan, Dana G, Shin, Taehwan, Benjamin, Lawrence N P, Walsh, Dominic M, Selkoe, Dennis J, Young-Pearse, Tracy L

“…Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by extracellular plaques containing amyloid β (Aβ)-protein and intracellular…”
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics by Hardy, John, Selkoe, Dennis J.

“…It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid…”
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Alzheimer's Disease: Genes, Proteins, and Therapy by Selkoe, Dennis J

“…Department of Neurology and Program in Neuroscience, Harvard Medical School, and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston,…”
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N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation by Bartels, Tim, Kim, Nora C, Luth, Eric S, Selkoe, Dennis J

“…A switch in the conformational properties of α-synuclein (αS) is hypothesized to be a key step in the pathogenic mechanism of Parkinson's disease (PD). Whereas…”
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