Search Results - "Selkoe, D.J."

Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism by Adom, M.A., Hahn, W.N., McCaffery, T.D., Moors, T.E., Zhang, X., Svenningsson, P., Selkoe, D.J., Fanning, S., Nuber, S.

“…Impaired lipid metabolism is a risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB) and can shift the physiological α-synuclein (αS)…”
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The APP family of proteins: similarities and differences by Walsh, D M, Minogue, A M, Sala Frigerio, C, Fadeeva, J V, Wasco, W, Selkoe, D J

“…Overwhelming evidence indicates that the Abeta (amyloid beta-peptide) plays a critical role in the pathogenesis of Alzheimer's disease. Abeta is derived from…”
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Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation by Lemere, C.A., Blusztajn, J.K., Yamaguchi, H., Wisniewski, T., Saido, T.C., Selkoe, D.J.

“…Patients with trisomy 21 [Down syndrome (DS)] progressively develop amyloid β-protein (Aβ) deposits and then other features of Alzheimer's disease (AD),…”
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Mass spectrometry of purified amyloid beta protein in Alzheimer's disease by Mori, H, Takio, K, Ogawara, M, Selkoe, D J

“…The amyloid beta-protein (A beta) that is progressively deposited in Alzheimer's disease (AD) arises from proteolysis of the integral membrane protein,…”
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Activation of protein kinase C inhibits cellular production of the amyloid beta-protein by HUNG, A. Y, HAASS, C, NITSCH, R. M, WEI QIAO QIU, CITRON, M, WURTMAN, R. J, GROWDON, J. H, SELKOE, D. J

“…The 39-43-amino acid amyloid beta-protein (A beta), which is progressively deposited in cerebral plaques and blood vessels in Alzheimer's disease (AD), is…”
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Naturally occurring free D-aspartate is a nuclear component of cells in the mammalian hypothalamo-neurohypophyseal system by Wang, H, Wolosker, H, Morris, J.F, Pevsner, J, Snyder, S.H, Selkoe, D.J

“…It is generally believed that only L-amino acids have a physiological role in species other than bacteria. Recently, the existence of some D-amino acids,…”
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A Is for Amyloid by Selkoe, D. J.

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Folding proteins in fatal ways by Selkoe, Dennis J

“…Human diseases characterized by insoluble extracellular deposits of proteins have been recognized for almost two centuries. Such amyloidoses were once thought…”
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P32 Phase III studies of crenezumab in early (prodromal-to-mild) Alzheimers disease (CREAD/CREAD2): Biomarker results by Bittner, T., Duning, T., Rabe, C., Clayton, D., Quartino, A., Bohorquez, S. Sanabria, Hu, N., Rabbia, M., Shimizu, H., Eichenlaub, U., Smith, J., Honigberg, L., Selkoe, D.J., Ostrowitzki, S.

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Developing Preventive Therapies for Chronic Diseases: Lessons Learned from Alzheimer's Disease by Selkoe, D.J

“…A remarkable rise in life expectancy during the past century has made Alzheimer's disease (AD) the most common form of progressive intellectual failure in…”
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Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex by Callahan, D.G., Taylor, W.M., Tilearcio, M., Cavanaugh, T., Selkoe, D.J., Young-Pearse, T.L.

“…It is widely accepted that amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease. In addition, APP has been proposed…”
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The Future of Anti-Amyloid Trials by Aisen, P. S., Cummings, J., Doody, R., Kramer, L., Salloway, S., Selkoe, D. J., Sims, J., Sperling, R. A., Vellas, B.

“…The termination of many clinical trials of amyloid-targeting therapies for the treatment of Alzheimer’s disease (AD) has had a major impact on the AD clinical…”
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Intramembrane Proteases: Mixing Oil and Water by Wolfe, Michael S., Selkoe, Dennis J.

“…There are four classes of proteases and peptidases classified according to which amino acid residues in the enzyme catalyze the breaking of an amide bond in…”
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[P2.49]: Secreted amyloid beta and impaired neurotrophin transport: Potential mediators of abnormal cns development and neurodegeneration in down syndrome by Maloney, M.T., Wu, C., Davis, R.C., Minamide, L.S., Podlisny, M., Selkoe, D.J.

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Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor by HAASS, C, HUNG, A. Y, SELKOE, D. J, TEPLOW, D. B

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the extracellular deposition of amyloid beta-protein (A beta), a molecule…”
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beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms by HAASS, C, HUNG, A. Y, SCHLOSSMACHER, M. G, TEPLOW, D. B, SELKOE, D. J

“…We have analyzed the cellular processing pathways which produce the 4-kDa amyloid beta-peptide (A beta) and a 3-kDa derivative (p3) of the beta-amyloid…”
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Selective ectodomain phosphorylation and regulated cleavage of beta‐amyloid precursor protein by Hung, A.Y., Selkoe, D.J.

“…The beta‐amyloid precursor protein (beta APP) is a highly conserved integral membrane protein expressed in most mammalian tissues and found at highest levels…”
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Microtubule-associated protein tau is a major antigenic component of paired helical filaments in Alzheimer disease by Kosik, K.S, Joachim, C.L, Selkoe, D.J

“…The detailed protein composition of the paired helical filaments (PHF) that accumulate in human neurons in aging and Alzheimer disease is unknown. However, the…”
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β -amyloid Precursor Protein of Alzheimer Disease Occurs as 110- to 135-Kilodalton Membrane-Associated Proteins in Neural and Nonneural Tissues by Selkoe, Dennis J., Podlisny, Marcia Berman, Joachim, Catharine L., Vickers, Elizabeth A., Lee, Gloria, Fritz, Lawrence C., Oltersdorf, Tilman

“…Progressive cerebral deposition of extracellular filaments composed of the β -amyloid protein (β AP) is a constant feature of Alzheimer disease (AD). Since the…”
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Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF by Citron, M, Diehl, T.S, Capell, A, Haass, C, Teplow, D.B, Selkoe, D.J

“…Cerebral deposition of amyloid β protein (Aβ) is an early and critical feature of Alzheimer's disease. Aβ production requires the proteolytic release of Aβ…”
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