Degradable covalently-linked siloxane-phosphazene polymer for drug loading and releasing
A novel porous hydrolytically degradable cross-linked polymer was obtained via polycondensation reaction between hexaphenoxycyclotriphosphazene and octa(tetramethylammonium)silicate. The synthesized polymer was characterized by solid NMR, FTIR, nitrogen adsorption etc. This polymer showed perspectiv...
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| Published in: | Reactive & functional polymers Vol. 182; p. 105491 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier B.V
01-01-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | A novel porous hydrolytically degradable cross-linked polymer was obtained via polycondensation reaction between hexaphenoxycyclotriphosphazene and octa(tetramethylammonium)silicate. The synthesized polymer was characterized by solid NMR, FTIR, nitrogen adsorption etc. This polymer showed perspectives in the use as container for loading and releasing of drug, which was shown with the use of Rhodamine-6G (Rh6G) as model compound. It was shown that due to the presence of hydrolytically unstable P-O-Si fragments the obtained porous polymer can load Rhodamine-6G and release it with various rates, depending on pH value of the medium.
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•A novel porous material was obtained through crosslinking polycondensation between silicate and cyclophosphazene monomers.•With the use of Rhodamine 6G it was shown that the porous polymer can be used for loading and release of active substances•The release rate can be tuned by changing pH value, which can lead to hydrolysis of P-O-Si bond of the porous polymer |
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| ISSN: | 1381-5148 |
| DOI: | 10.1016/j.reactfunctpolym.2022.105491 |