Comparative Assessment of the Influence of Embolizing Agents on the Adrenal Parenchyma

Comparative Assessment of the Influence of Embolizing Agents on the Adrenal Parenchyma

A comparative analysis of morphological and functional changes in the adrenal glands after embolization of supplying arteries with Lifepearl microspheres (100±25 μm; Terumo) and with a solution of polidocanol (Aethoxysklerol, Kreussler Pharma) was performed in male Vietnamese Lop-Bellied pigs ( n =2...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 177; no. 4; pp. 502 - 506
Main Authors: Annayev, M. S., Stegniy, K. V., Geltser, B. I., Goncharuk, R. A., Seliutin, S. M., Maslyantsev, E. V., Fisenko, V. G., Dvoinikova, E. R., Zvereva, L. V.
Format: Journal Article
Language:English
Published: New York Springer US 01-08-2024
Springer Nature B.V
Subjects:
Adrenal cortex
Adrenal glands
Arteries
Biomedical and Life Sciences
Biomedicine
Body fat
Catheters
Cell Biology
Comparative analysis
Contrast agents
Embolization
Hogs
Hyperplasia
Hypotension
Inflammation
Internal Medicine
Intubation
Laboratory animals
Laboratory Medicine
Microspheres
Morphology
Parenchyma
Pathology
Vasoactive agents
Veins & arteries
adrenal hyperplasia
embolization
polidocanol
microspheres
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Summary:A comparative analysis of morphological and functional changes in the adrenal glands after embolization of supplying arteries with Lifepearl microspheres (100±25 μm; Terumo) and with a solution of polidocanol (Aethoxysklerol, Kreussler Pharma) was performed in male Vietnamese Lop-Bellied pigs ( n =20). The introduction of the microspheres into the arterial bed did not affect the adrenal parenchyma. However, the injection of the liquid sclerosing agent caused foci of productive inflammation leading to the formation of sclerotic tissue and reduction of the volume of glandular tissue. Administration of the sclerosant was accompanied by arterial hypotension, an indirect indication of a decrease in vasoactive hormone production by the adrenal cortex. These findings suggest that polidocanol can be used as an embolization agent for hyperplastic diseases of the adrenal cortex.
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ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06215-8