Search Results - "Selimkhanov, Jangir"

Synchronized cycles of bacterial lysis for in vivo delivery by Din, M. Omar, Danino, Tal, Prindle, Arthur, Skalak, Matt, Selimkhanov, Jangir, Allen, Kaitlin, Julio, Ellixis, Atolia, Eta, Tsimring, Lev S., Bhatia, Sangeeta N., Hasty, Jeff

“…Clinically relevant bacteria have been engineered to lyse synchronously at a threshold population density and release genetically encoded therapeutics;…”
Get full text

Accurate information transmission through dynamic biochemical signaling networks by Selimkhanov, Jangir, Taylor, Brooks, Yao, Jason, Pilko, Anna, Albeck, John, Hoffmann, Alexander, Tsimring, Lev, Wollman, Roy

“…Stochasticity inherent to biochemical reactions (intrinsic noise) and variability in cellular states (extrinsic noise) degrade information transmitted through…”
Get full text

Rapid and tunable post-translational coupling of genetic circuits by Prindle, Arthur, Selimkhanov, Jangir, Li, Howard, Razinkov, Ivan, Tsimring, Lev S., Hasty, Jeff

“…Protease competition is used to produce rapid and tunable coupling of genetic circuits, enabling a coupled clock network that can encode independent…”
Get full text

Entrainment of a Population of Synthetic Genetic Oscillators by Mondragón-Palomino, Octavio, Danino, Tal, Selimkhanov, Jangir, Tsimring, Lev, Hasty, Jeff

“…Biological clocks are self-sustained oscillators that adjust their phase to the daily environmental cycles in a process known as entrainment. Molecular…”
Get full text

Self-reproducing catalyst drives repeated phospholipid synthesis and membrane growth by Hardy, Michael D., Yang, Jun, Selimkhanov, Jangir, Cole, Christian M., Tsimring, Lev S., Devaraj, Neal K.

“…Cell membranes are dynamic structures found in all living organisms. There have been numerous constructs that model phospholipid membranes. However, unlike…”
Get full text

Dynamic Localization of the Cyanobacterial Circadian Clock Proteins by Cohen, Susan E., Erb, Marcella L., Selimkhanov, Jangir, Dong, Guogang, Hasty, Jeff, Pogliano, Joe, Golden, Susan S.

“…The cyanobacterial circadian clock system has been extensively studied, and the structures, interactions, and biochemical activities of the central oscillator…”
Get full text

Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module by Longo, Diane M, Selimkhanov, Jangir, Kearns, Jeffrey D, Hasty, Jeff, Hoffmann, Alexander, Tsimring, Lev S

“…Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What…”
Get full text

Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making by Kondic, Anna, Bottino, Dean, Harrold, John, Kearns, Jeffrey D, Musante, C J, Odinecs, Aleksandrs, Ramanujan, Saroja, Selimkhanov, Jangir, Schoeberl, Birgit

“…The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform…”
Get full text

Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies by Selimkhanov, Jangir, Thompson, W Clayton, Patterson, Terrell A, Hadcock, John R, Scott, Dennis O, Maurer, Tristan S, Musante, Cynthia J

“…The purpose of this work is to develop a mathematical model of energy balance and body weight regulation that can predict species-specific response to common…”
Get full text

Optimal movement in the prey strikes of weakly electric fish: a case study of the interplay of body plan and movement capability by Postlethwaite, Claire M, Psemeneki, Tiffany M, Selimkhanov, Jangir, Silber, Mary, MacIver, Malcolm A

“…Animal behaviour arises through a complex mixture of biomechanical, neuronal, sensory and control constraints. By focusing on a simple, stereotyped movement,…”
Get full text

Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance by Kozminski, Kirk D, Selimkhanov, Jangir, Heyward, Scott, Zientek, Michael A

“…Aldehyde oxidase (AOX) is a soluble, cytosolic enzyme that metabolizes various -heterocyclic compounds and organic aldehydes. It has wide tissue distribution…”
Get full text

A Quantitative Systems Pharmacology Model Describing the Cellular Kinetic‐Pharmacodynamic Relationship for a Live Biotherapeutic Product to Support Microbiome Drug Development by Renardy, Marissa, Prokopienko, Alexander J., Maxwell, Joseph R., Flusberg, Deborah A., Makaryan, Sahak, Selimkhanov, Jangir, Vakilynejad, Majid, Subramanian, Kalyanasundaram, Wille, Lucia

“…Live biotherapeutic products (LBPs) are human microbiome therapies showing promise in the clinic for a range of diseases and conditions. Describing the…”
Get full text

Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1 by Sabat, Mark, Carney, Daniel W., Hernandez-Torres, Gloria, Gibson, Tony S., Balakrishna, Deepika, Zou, Hua, Xu, Rui, Chen, Chien-Hung, de Jong, Ron, Dougan, Douglas R., Qin, Ling, Bigi-Botterill, Simone V., Chambers, Alison, Miura, Joanne, Johnson, Lucas K., Ermolieff, Jacques, Johns, Deidre, Selimkhanov, Jangir, Kwok, Lily, DeMent, Kevin, Proffitt, Chris, Vu, Phong, Lindsey, Erick A., Ivetac, Tony, Jennings, Andy, Wang, Haixia, Manam, Padma, Santos, Cipriano, Fullenwider, Cody, Manohar, Rohan, Flick, Andrew C.

“…Selective inhibition of the RGD (Arg-Gly-Asp) integrin αvβ1 has been recently identified as an attractive therapeutic approach for the treatment of liver…”
Get full text

A quantitative analysis of statistical power identifies obesity endpoints for improved in vivo preclinical study design by Selimkhanov, Jangir, Thompson, W. Clayton, Guo, Juen, Hall, Kevin D., Musante, Cynthia J.

“…The design of well-powered in vivo preclinical studies is a key element in building knowledge of disease physiology for the purpose of identifying and…”
Get full text

Recent advances in single-cell studies of gene regulation by Selimkhanov, Jangir, Hasty, Jeff, Tsimring, Lev S

“…Graphical abstract Highlights ► We review methods for high-resolution visualization and the control of gene expression. ► The methods allow for simultaneous…”
Get full text

Current practices for QSP model assessment: an IQ consortium survey by Chan, Jason R, Allen, Richard, Boras, Britton, Cabal, Antonio, Damian, Valeriu, Gibbons, Francis D, Gulati, Abhishek, Hosseini, Iraj, Kearns, Jeffrey D, Saito, Ryuta, Cucurull-Sanchez, Lourdes, Selimkhanov, Jangir, Stein, Andrew M, Umehara, Kenichi, Wang, Guanyu, Wang, Weirong, Neves-Zaph, Susana

“…Quantitative Systems Pharmacology (QSP) modeling is increasingly applied in the pharmaceutical industry to influence decision making across a wide range of…”
Get full text

A Microfluidic Platform for Long-Term Monitoring of Algae in a Dynamic Environment by Luke, Chung Sze, Selimkhanov, Jangir, Baumgart, Leo, Cohen, Susan E, Golden, Susan S, Cookson, Natalie A, Hasty, Jeff

“…Culturing cells in microfluidic “lab-on-a-chip” devices for time lapse microscopy has become a valuable tool for studying the dynamics of biological systems…”
Get full text

A quantitative systems pharmacology model of colonic motility with applications in drug development by Das, Raibatak, Wille, Lucia, Zhang, Liming, Chen, Chunlin, Winchester, Wendy, Selimkhanov, Jangir, Wykosky, Jill, Apgar, Joshua F., Burke, John M., Rogge, Mark, Hua, Fei, Vakilynejad, Majid

“…We developed a mathematical model of colon physiology driven by serotonin signaling in the enteric nervous system. No such models are currently available to…”
Get full text

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-[kappa]B Signaling Module: e1003112 by Longo, Diane M, Selimkhanov, Jangir, Kearns, Jeffrey D, Hasty, Jeff, Hoffmann, Alexander, Tsimring, Lev S

“…Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What…”
Get full text

Genetic Circuits in Salmonella typhimurium by Prindle, Arthur, Selimkhanov, Jangir, Danino, Tal, Samayoa, Phillip, Goldberg, Anna, Bhatia, Sangeeta N, Hasty, Jeff

“…Synthetic biology has rapidly progressed over the past decade and is now positioned to impact important problems in health and energy. In the clinical arena,…”
Get full text