Search Results - "Seliger, Laurie"

DNA-Stable Isotope Probing Integrated with Metagenomics for Retrieval of Biphenyl Dioxygenase Genes from Polychlorinated Biphenyl-Contaminated River Sediment by Sul, Woo Jun, Park, Joonhong, Quensen, John F. III, Rodrigues, Jorge L.M, Seliger, Laurie, Tsoi, Tamara V, Zylstra, Gerben J, Tiedje, James M

“…Stable isotope probing with [¹³C]biphenyl was used to explore the genetic properties of indigenous bacteria able to grow on biphenyl in PCB-contaminated River…”
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Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors:  Potential Agents for Treatment of Erectile Dysfunction by Yu, Guixue, Mason, Helen, Wu, Ximao, Wang, Jian, Chong, Saeho, Beyer, Bruce, Henwood, Andrew, Pongrac, Ronald, Seliger, Laurie, He, Bin, Normandin, Diane, Ferrer, Pam, Zhang, Rongan, Adam, Leonard, Humphrey, William G, Krupinski, John, Macor, John E

“…Novel pyrazolopyridopyridazine derivatives have been prepared as potent and selective PDE5 inhibitors. Compound 6 has been identified as a more potent and…”
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Chemical synthesis and characterization of 7-methylguanosine cap analogs by Darzynkiewicz, Edward, Ekiel, Irena, Tahara, Stanley M, Seliger, Laurie S, Shatkin, Aaron J

“…Chemically synthesized nucleotide derivatives of 7-methylguanosine and guanosine were characterized with respect to their structural properties and functional…”
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Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction by Bi, Yingzhi, Stoy, Patrick, Adam, Leonard, He, Bin, Krupinski, John, Normandin, Diane, Pongrac, Ron, Seliger, Laurie, Watson, Andrew, Macor, John E

“…In a continuing effort to discover novel chemotypes as potent and selective PDE5 inhibitors for the treatment of male erectile dysfunction (ED), we have found…”
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N-3-Substituted Imidazoquinazolinones:  Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction by Rotella, David P, Sun, Zhong, Zhu, Yeheng, Krupinski, John, Pongrac, Ronald, Seliger, Laurie, Normandin, Diane, Macor, John E

“…Phosphodiesterase type 5 (PDE5) inhibitors with improved PDE isozyme selectivity relative to sildenafil may result in agents for the treatment of male erectile…”
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Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors:  Potential Agents for Treatment of Erectile Dysfunction by Yu, Guixue, Mason, Helen J, Wu, Ximao, Wang, Jian, Chong, Saeho, Dorough, Gary, Henwood, Andrew, Pongrac, Ronald, Seliger, Laurie, He, Bin, Normandin, Diane, Adam, Leonard, Krupinski, John, Macor, John E

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Optimization of Substituted N-3-Benzylimidazoquinazolinone Sulfonamides as Potent and Selective PDE5 Inhibitors by Rotella, David P, Sun, Zhong, Zhu, Yeheng, Krupinski, John, Pongrac, Ronald, Seliger, Laurie, Normandin, Diane, Macor, John E

“…A previous report from these laboratories identified the N-3-benzylimidazoquinazolinone nucleus as a more selective PDE5 inhibitor template compared to the…”
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The discovery of novel, potent and selective PDE5 inhibitors by Bi, Yingzhi, Stoy, Patrick, Adam, Leonard, He, Bin, Krupinski, John, Normandin, Diane, Pongrac, Ron, Seliger, Laurie, Watson, Andrew, Macor, John E

“…The design and synthesis of a novel scaffold for potent and selective PDE5 inhibitors are described. Compound 3a was more potent (PDE5 IC 50=0.31 nM) and…”
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Translational effects and sequence comparisons of the three serotypes of the reovirus S4 gene by Seliger, L S, Giantini, M, Shatkin, A J

“…Reovirus S4 RNA codes for the dsRNA-binding polypeptide sigma 3, a major virion outer capsid component that also has translational effects in both infected and…”
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