Search Results - "Seley, Katherine L."

Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides by Temburnikar, Kartik, Seley-Radtke, Katherine L

“…C-nucleosides have intrigued biologists and medicinal chemists since their discovery in 1950's. In that regard, C-nucleosides and their synthetic analogues…”
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An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases by Vichier‐Guerre, Sophie, Ku, Therese C., Pochet, Sylvie, Seley‐Radtke, Katherine L.

“…The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand…”
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Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides by Fateev, Ilja V., Kharitonova, Maria I., Antonov, Konstantin V., Konstantinova, Irina D., Stepanenko, Vasily N., Esipov, Roman S., Seela, Frank, Temburnikar, Kartik W., Seley-Radtke, Katherine L., Stepchenko, Vladimir A., Sokolov, Yuri A., Miroshnikov, Anatoly I., Mikhailopulo, Igor A.

“…A wide range of natural purine analogues was used as probe to assess the mechanism of recognition by the wild‐type (WT) E. coli purine nucleoside phosphorylase…”
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Comparison of the Old and New - Novel Mechanisms of Action for Anti-coronavirus Nucleoside Analogues by Thames, Joy E, Seley-Radtke, Katherine L

“…Over the past two and a half years the world has seen a desperate scramble to find a treatment for SARS-CoV-2 and COVID. In that regard, nucleosides have long…”
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Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity by Yates, Mary K, Chatterjee, Payel, Flint, Mike, Arefeayne, Yafet, Makuc, Damjan, Plavec, Janez, Spiropoulou, Christina F, Seley-Radtke, Katherine L

“…Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of…”
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Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2- d ]pyrimidines as Potential Anti-Cancer Therapeutics by Cawrse, Brian M, Robinson, Nia'mani M, Lee, Nina C, Wilson, Gerald M, Seley-Radtke, Katherine L

“…Pyrrolo[3,2- ]pyrimidines have been studied for many years as potential lead compounds for the development of antiproliferative agents. Much of the focus has…”
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Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents by Khandazhinskaya, Anastasia L, Matyugina, Elena S, Solyev, Pavel N, Wilkinson, Maggie, Buckheit, Karen W, Buckheit, Jr, Robert W, Chernousova, Larisa N, Smirnova, Tatiana G, Andreevskaya, Sofya N, Alzahrani, Khalid J, Natto, Manal J, Kochetkov, Sergey N, de Koning, Harry P, Seley-Radtke, Katherine L

“…Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two…”
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Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines by Temburnikar, Kartik W., Ross, Christina R., Wilson, Gerald M., Balzarini, Jan, Cawrse, Brian M., Seley-Radtke, Katherine L.

“…[Display omitted] In vitro evaluation of the halogenated pyrrolo[3,2-d]pyrimidines identified antiproliferative activities in compounds 1 and 2 against four…”
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The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold by Seley-Radtke, Katherine L., Yates, Mary K.

“…This is the first of two invited articles reviewing the development of nucleoside-analogue antiviral drugs, written for a target audience of virologists and…”
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Creation and Discovery of Ligand-Receptor Pairs for Transcriptional Control with Small Molecules by Schwimmer, Lauren J., Rohatgi, Priyanka, Azizi, Bahareh, Seley, Katherine L., Doyle, Donald F., Evans, Ronald M.

“…The nuclear receptor retinoid X receptor (RXR) is a ligand-activated transcription factor. To create receptors for a new ligand, a structure-based approach was…”
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The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold by Yates, Mary K., Seley-Radtke, Katherine L.

“…This is the second of two invited articles reviewing the development of nucleoside analogue antiviral drugs, written for a target audience of virologists and…”
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Design and synthesis of a series of truncated neplanocin fleximers by Zimmermann, Sarah C, O'Neill, Elizaveta, Ebiloma, Godwin U, Wallace, Lynsey J M, De Koning, Harry P, Seley-Radtke, Katherine L

“…In an effort to study the effects of flexibility on enzyme recognition and activity, we have developed several different series of flexible nucleoside…”
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Anticancer Properties of Halogenated Pyrrolo[3,2‐d]pyrimidines with Decreased Toxicity via N5 Substitution by Cawrse, Brian M., Lapidus, Rena S., Cooper, Brandon, Choi, Eun Yong, Seley‐Radtke, Katherine L.

“…Halogenated pyrrolo[3,2‐d]pyrimidine analogues have shown antiproliferative activity in recent studies, with cell accumulation occurring in the G2/M stage…”
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1,6-Bis[(benzyloxy)methyl]uracil derivatives—Novel antivirals with activity against HIV-1 and influenza H1N1 virus by Geisman, Alexander N., Valuev-Elliston, Vladimir T., Ozerov, Alexander A., Khandazhinskaya, Anastasia L., Chizhov, Alexander O., Kochetkov, Sergey N., Pannecouque, Christophe, Naesens, Lieve, Seley-Radtke, Katherine L., Novikov, Mikhail S.

“…[Display omitted] A series of 1,6-bis[(benzyloxy)methyl]uracil derivatives combining structural features of both diphenyl ether and pyridone types of NNRTIs…”
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5-Arylaminouracil Derivatives: New Inhibitors of Mycobacterium tuberculosis by Matyugina, Elena, Novikov, Mikhail, Babkov, Denis, Ozerov, Alexander, Chernousova, Larisa, Andreevskaya, Sofia, Smirnova, Tatiana, Karpenko, Inna, Chizhov, Alexander, Murthu, Pravin, Lutz, Stefan, Kochetkov, Sergei, Seley-Radtke, Katherine L., Khandazhinskaya, Anastasia L.

“…Three series of 5‐arylaminouracil derivatives, including 5‐(phenylamino)uracils, 1‐(4′‐hydroxy‐2′‐cyclopenten‐1′‐yl)‐5‐(phenylamino)uracils, and…”
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Thiophene-expanded guanosine analogues of Gemcitabine by Chen, Zhe, Ku, Therese C., Seley-Radtke, Katherine L.

“…[Display omitted] The chemotherapeutic drug Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine, has long been the standard of care for a number of cancers…”
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Proximal fleximer analogues of 2′-deoxy-2′-fluoro-2′-methyl purine nucleos(t)ides: Synthesis and preliminary pharmacokinetic and antiviral evaluation by Waters, Charles D., Carlyle, Evan, Smart, Viviana, Rege, Apurv, Bieberich, Charles J., Seley-Radtke, Katherine L.

“…Photo Credit: CDC/Cynthia Goldsmith. [Display omitted] •Optimized synthesis of 2′d-2′F-2′Me-ribofuranose fleximer nucleos(t)ide analogues.•Improved yields and…”
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Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity by Peters, Hannah L., Jochmans, Dirk, de Wilde, Adriaan H., Posthuma, Clara C., Snijder, Eric J., Neyts, Johan, Seley-Radtke, Katherine L.

“…[Display omitted] A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety…”
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Substrate Discrimination by the Human GTP Fucose Pyrophosphorylase by Quirk, Stephen, Seley, Katherine L

“…GTP-l-fucose pyrophosphorylase (GFPP, E. C. 2.7.7.30) catalyzes the reversible condensation of guanosine triphosphate and β-l-fucose-1-phosphate to form the…”
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Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro by Thames, Joy E., Waters, Charles D., Valle, Coralie, Bassetto, Marcella, Aouadi, Wahiba, Martin, Baptiste, Selisko, Barbara, Falat, Arissa, Coutard, Bruno, Brancale, Andrea, Canard, Bruno, Decroly, Etienne, Seley-Radtke, Katherine L.

“…[Display omitted] Flaviviruses, such as Dengue (DENV) and Zika (ZIKV) viruses, represent a severe health burden. There are currently no FDA-approved…”
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