Search Results - "Selepe, Mamoalosi A"

Application of the Suzuki-Miyaura reaction in the synthesis of flavonoids by Selepe, Mamoalosi A, Van Heerden, Fanie R

“…The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only…”
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Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae) by Moyo, Phanankosi, Kunyane, Phaladi, Selepe, Mamoalosi A, Eloff, Jacobus N, Niemand, Jandeli, Louw, Abraham I, Maharaj, Vinesh J, Birkholtz, Lyn-Marie

“…Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of…”
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Antiproliferative Activity of Buddleja saligna (Willd.) against Melanoma and In Vivo Modulation of Angiogenesis by Twilley, Danielle, Thipe, Velaphi C, Kishore, Navneet, Bloebaum, Pierce, Roma-Rodrigues, Catarina, Baptista, Pedro V, Fernandes, Alexandra R, Selepe, Mamoalosi A, Langhansova, Lenka, Katti, Kattesh, Lall, Namrita

“…Melanoma cells secrete pro-angiogenic factors, which stimulates growth, proliferation and metastasis, and therefore are key therapeutic targets. (BS), and an…”
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In Vitro Antiproliferative Activity of Ptaeroxylon obliquum Leaf Extracts, Fractions and Isolated Compounds on Several Cancer Cell Lines by Khunoana, Edward T., Eloff, Jacobus N., Ramadwa, Thanyani E., Nkadimeng, Sanah M., Selepe, Mamoalosi A., McGaw, Lyndy J.

“…Several cancers are induced by microbial infections or chronic inflammation. Ptaeroxylon obliquum is traditionally used to treat various infections…”
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Triterpenoids from Protorhus longifolia Exhibit Hypocholesterolemic Potential via Regulation of Cholesterol Biosynthesis and Stimulation of Low-Density Lipoprotein Uptake in HepG2 Cells by Ndlovu, Musawenkosi, Serem, June C., Selepe, Mamoalosi A., Opoku, Andrew R., Bester, Megan J., Apostolides, Zeno, Mosa, Rebamang A.

“…The increasing incidence of hypercholesterolemia-related diseases even in the presence of the currently available cholesterol-lowering drugs indicates a need…”
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Total synthesis of the pyranocoumaronochromone lupinalbin H by Selepe, Mamoalosi A., Drewes, Siegfried E., van Heerden, Fanie R.

“…The pyranocoumaronochromone lupinalbin H was synthesized in three major steps, which involved preparation of 2′-hydroxygenistein by the Suzuki–Miyaura…”
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Isoflavone Derivatives as Potential Anticancer Agents: Synthesis and Bioactivity Studies by Selepe, Mamoalosi

“…Isoflavones are phenolic natural compounds with a C6C3C6 framework. They possess a plethora of biological activities that are associated with putative benefits…”
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Synthesis of Isoflavones by Tandem Demethylation and Ring-Opening/Cyclization of Methoxybenzoylbenzofurans by Kunyane, Phaladi, Sonopo, Molahlehi S, Selepe, Mamoalosi A

“…The unexpected conversion of benzoylbenzofurans into isoflavones through an intramolecular cascade that involves deprotection and ring-opening/cyclization is…”
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Synthesis and Antifungal Activity of Chromones and Benzoxepines from the Leaves of Ptaeroxylon obliquum by Malefo, Modibo S, Ramadwa, Thanyani E, Famuyide, Ibukun M, McGaw, Lyndy J, Eloff, Jacobus N, Sonopo, Molahlehi S, Selepe, Mamoalosi A

“…This study reports the first total synthesis of the bioactive oxepinochromones 12-O-acetyleranthin (8) (angular isomer) and 12-O-acetylptaeroxylinol (9)…”
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Antifungal Compounds from the Leaves of Rhynchosia minima by Adewole, Adetola H., Famuyide, Ibukun M., McGaw, Lyndy J., Selepe, Mamoalosi A., October, Natasha

“…Rhynchosia minima, commonly known as jumby bean, is used as a remedy for respiratory ailments in various parts of the world. It is also used by South African…”
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Synthesis and evaluation of benzoylbenzofurans and isoflavone derivatives as sirtuin 1 inhibitors with antiproliferative effects on cancer cells by Selepe, Mamoalosi A., Kunyane, Phaladi, Seboletswe, Pule, Nair, Shankari, Cele, Nosipho, Engelbrecht, Monique, Joubert, Daniël F., Vandevoorde, Charlot, Singh, Parvesh, Sonopo, Molahlehi S.

“…[Display omitted] •Isoflavone analogues were synthesized from benzoylbenzofuran precursors.•Benzoylbenzofurans and isoflavones inhibited MDA-MB-231 cancer cell…”
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Bioactive Lignans from Hypoestes aristata by Ramabulana, Tshifhiwa, Scheepers, Luki-Marié, Moodley, Thirshen, Maharaj, Vinesh J, Stander, André, Gama, Ntombenhle, Ferreira, Daneel, Sonopo, Molahlehi S, Selepe, Mamoalosi A

“…Phytochemical investigation of extracts of the stems of Hypoestes aristata led to the isolation of nine lignans that included four known compounds, namely,…”
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Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity by Aro, Abimbola O, Dzoyem, Jean P, Awouafack, Maurice D, Selepe, Mamoalosi A, Eloff, Jacobus N, McGaw, Lyndy J

“…Tuberculosis is a deadly disease caused by Mycobacterium species. The use of medicinal plants is an ancient global practice for the treatment and prevention of…”
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Phytochemical Profiling and Isolation of Bioactive Compounds from Leucosidea sericea (Rosaceae) by Ramabulana, Tshifhiwa, Ndlovu, Musawenkosi, Mosa, Rebamang A, Sonopo, Molahlehi S, Selepe, Mamoalosi A

“…In the study, ultraperformance liquid chromatography–quadrupole time-of-flight–mass spectrometry analysis of Leucosidea sericea leaf and stem extracts led to…”
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Total Synthesis of the Pyranoisoflavone Kraussianone 1 and Related Isoflavones by Selepe, Mamoalosi A, Drewes, Siegfried E, van Heerden, Fanie R

“…The first total synthesis of the pyranoisoflavone kraussianone 1 (1) is described. The key steps involved the Suzuki−Miyaura reaction for the construction of…”
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Antiproliferative Activity of IBuddleja saligna/I against Melanoma and IIn Vivo/I Modulation of Angiogenesis by Twilley, Danielle, Thipe, Velaphi C, Kishore, Navneet, Bloebaum, Pierce, Roma-Rodrigues, Catarina, Baptista, Pedro V, Fernandes, Alexandra R, Selepe, Mamoalosi A, Langhansova, Lenka, Katti, Kattesh, Lall, Namrita

“…Melanoma cells secrete pro-angiogenic factors, which stimulates growth, proliferation and metastasis, and therefore are key therapeutic targets. Buddleja…”
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