Search Results - "Sekulic, Sonja"

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules by Laske, Stephan, Paudel, Amrit, Scheibelhofer, Otto

“…Pharmaceutical solid oral dosage product manufacturing is a well-established, yet revolutionizing area. To this end, process analytical technology (PAT)…”
Get more information

Absolute molecular weight determination of hypromellose acetate succinate by size exclusion chromatography: Use of a multi angle laser light scattering detector and a mixed solvent by Chen, Raymond, Ilasi, Nicholas, Sekulic, Sonja S.

“…Molecular weight distribution is an important quality attribute for hypromellose acetate succinate (HPMCAS), a pharmaceutical excipient used in spray-dried…”
Get full text

De-risking Pharmaceutical Tablet Manufacture Through Process Understanding, Latent Variable Modeling, and Optimization Technologies by Muteki, Koji, Swaminathan, Vidya, Sekulic, Sonja S., Reid, George L.

“…In pharmaceutical tablet manufacturing processes, a major source of disturbance affecting drug product quality is the (lot-to-lot) variability of the incoming…”
Get full text

Multivariate data analysis for Raman imaging of a model pharmaceutical tablet by Zhang, Lin, Henson, Mark J., Sekulic, S. Sonja

“…Spectroscopic imaging techniques provide spatial and spectral information about a sample simultaneously and are finding ever-increasing application in the…”
Get full text

On-Line Monitoring of Powder Blend Homogeneity by Near-Infrared Spectroscopy by Sekulic, S. Sonja, Ward, Howard W, Brannegan, Daniel R, Stanley, Elizabeth D, Evans, Christine L, Sciavolino, Steven T, Hailey, Perry A, Aldridge, Paul K

“…Near-infrared spectroscopy is evaluated as an on-line technique for monitoring the homogeneity of a pharmaceutical blend during the blending process. Blends…”
Get full text

Simultaneously measuring concentrations of a model drug and a model excipient in solution using ultrasonic spectrometry by Chen, Raymond R., Zelesky, Todd, Ilasi, Nicholas, Sekulic, Sonja S.

“…A newly commercialized high-resolution ultrasonic spectrometer was evaluated for simultaneously measuring concentrations of a model excipient (hypromellose…”
Get full text

Small footprint liquid chromatography-mass spectrometry for pharmaceutical reaction monitoring and automated process analysis by Hemida, Mohamed, Haddad, Paul R., Lam, Shing C., Coates, Lewellwyn J., Riley, Frank, Diaz, Angel, Gooley, Andrew A., Wirth, Hans-Jürgen, Guinness, Steven, Sekulic, Sonja, Paull, Brett

“…•Small footprint LC-UV/MS system for pharmaceutical process monitoring.•In-fumehood reaction monitoring by LC-UV/MS.•Automated sample dilution, derivatisation,…”
Get full text

A robotic dissolution system with on-line fiber-optic UV analysis by Aldridge, P K, Melvin, D W, Williams, B A, Bratin, K, Kostek, L J, Sekulic, S S

“…An automated, robotic system has been developed with on-line UV fiber optics for real time dissolution analysis of solid dosage forms. The system is comprised…”
Get more information

ECOLOGY BETWEEN POLITICS AND ECONOMY/EKOLOGIJA IZMEDU POLITIKE I EKONOMIJE by Markovic, Slobodan I, Sekulic, Sonja Dragovic

“…Modern trends of socio-economic and technological development have a feature of permanent and the quickest changes in the history of human civilization. The…”
Get full text

Automated peak tracking for comprehensive impurity profiling in orthogonal liquid chromatographic separation using mass spectrometric detection by Xue, Gang, Bendick, Anne D., Chen, Raymond, Sekulic, Sonja S.

“…The presence and quantity of impurities in pharmaceutical drugs can have a significant impact on their quality and safety. With the continuous pressure for…”
Get full text

Appearance of Discontinuities in Spectra Transformed by the Piecewise Direct Instrument Standardization Procedure by Gemperline, Paul J, Cho, JungHwan, Aldridge, Paul K, Sekulic, S. Sonja

“…Several years ago, we noted that spectra transformed by the piecewise direct standardization (PDS) method may contain discontinuities. Having noticed that the…”
Get full text

Automated peak tracking for comprehensive impurity profiling in orthogonal liquid chromatographic separation using mass spectrometric detection by GANG XUE, BENDICK, Anne D, CHEN, Raymond, SEKULIC, Sonja S

“…The presence and quantity of impurities in pharmaceutical drugs can have a significant impact on their quality and safety. With the continuous pressure for…”
Get full text

Nonlinear multivariate calibration methods in analytical chemistry by Sekulic, Sonja, Seasholtz, Mary Beth, Wang, Ziyi, Kowalski, Bruce R, Lee, Samuel E, Holt, Bradley R

“…The data explosion created by the increased resolving power of analytical instruments has placed more emphasis on data analysis. An overview of multivariate…”
Get full text

Foreign particles testing in orally inhaled and nasal drug products by Blanchard, James, Coleman, James, Hayling, Claire D'Abreu, Ghaderi, Raouf, Haeberlin, Barbara, Hart, John, Jensen, Steen, Malcolmson, Richard, Mittelman, Stanley, Nagao, Lee M, Sekulic, Sonja, Snodgrass-Pilla, Caesar, Sundahl, Mikael, Thompson, Glenn, Wolff, Ronald

“…The International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) presents this paper in order to contribute to public discussion…”
Get full text

Alternative liquid chromatographic method for determination of the methoxyl and 2-hydroxypropoxyl content in cellulose ether derivatives by RASHAN, Joe, CHEN, Raymond, ZELESKY, Todd, SEKULIC, Sonja

“…An alternative liquid chromatographic (LC) method was developed and validated for the simultaneous determination of methoxyl and 2-hydroxypropoxyl substituents…”
Get full text

Development and validation of a cost-effective, efficient, and robust liquid chromatographic method for the simultaneous determination of the acetyl and succinoyl content in hydroxypropyl methylcellulose acetate succinate polymer by CHEN, Raymond, SEKULIC, Sonja, ZELESKY, Todd

“…A reversed-phase liquid chromatographic method was developed and validated for the determination of the content of free acetic acid, free succinic acid, acetyl…”
Get full text

Automated system for the on-line monitoring of powder blending processes using near-infrared spectroscopy: Part II. Qualitative approaches to blend evaluation by Sekulic, S.Sonja, Wakeman, John, Doherty, Phil, Hailey, Perry A.

“…Near Infrared (NIR) spectroscopy is seen as a very powerful tool in a variety of applications involving powder characterisation. Here we deal with a typical…”
Get full text

APPLICATIONS OF A SENSITIVE LASER POLARIMETRIC HPLC DETECTOR: CONFIRMATION OF ENANTIOMERIC EXCESS FOR DANOFLOXACIN AND ANALYSIS OF A NOVEL MACROLIDE by Wigman, Larry S., Hoyt, Douglas S., Sekulic, Sonja S.

“…A commercially available laser-based polarimetric detector (Chiral Detector) was used to confirm the enantiomeric excess of danofloxacin and to analyze a novel…”
Get full text

Nonlinear Multivariate Calibration Methods in Analytical Chemistry by Sekulic, Sonja, Seasholtz, Mary Beth, Wang, Ziyi, Kowalski, Bruce R, Lee, Samuel E, Holt, Bradley R

Get full text

EKOLOGIJA IZMEĐU POLITIKE I EKONOMIJE by Marković, Slobodan, Dragović Sekulić, Sonja

“…Suvremeni tijekovi društveno-ekonomskog i tehnološko-tehničkog razvoja imaju obilježje stalnih i, neusporedivo, najbržih promjena u povijesti ljudske…”
Get full text