Search Results - "Sekino, Nobufumi"

Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments by Sekino, Nobufumi, Selim, Magdy, Shehadah, Amjad

“…Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis causes cerebral dysfunction in the short and long…”
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Tumor‐derived exosomes influence the cell cycle and cell migration of human esophageal cancer cell lines by Matsumoto, Yasunori, Kano, Masayuki, Murakami, Kentaro, Toyozumi, Takeshi, Suito, Hiroshi, Takahashi, Masahiko, Sekino, Nobufumi, Shiraishi, Tadashi, Kamata, Toshiki, Ryuzaki, Takahiro, Hirasawa, Soichiro, Kinoshita, Kazuya, Matsubara, Hisahiro

“…Our laboratory previously reported the usefulness as biomarkers of exosomes in the plasma of esophageal squamous cell carcinoma (ESCC) patients. However, the…”
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Biased expression of mutant alleles in cancer-related genes in esophageal squamous cell carcinoma by Takahashi, Masahiko, Hosomichi, Kazuyoshi, Nakaoka, Hirofumi, Sakata, Haruhito, Uesato, Naoya, Murakami, Kentaro, Kano, Masayuki, Toyozumi, Takeshi, Matsumoto, Yasunori, Isozaki, Tetsuro, Sekino, Nobufumi, Otsuka, Ryota, Inoue, Itsuro, Matsubara, Hisahiro

“…Background Recent progress of large-scale international studies has provided comprehensive catalogs of somatic mutations in cancers. Additionally, it has…”
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An anti-alcoholism drug, disulfiram and copper complex improves radio-resistance of tumor-initiating cells in esophageal squamous cell carcinoma by Qian, Li, Murakami, Kentaro, Toyozumi, Takeshi, Matsumoto, Yasunori, Otsuka, Ryota, Sekino, Nobufumi, Endo, Satoshi, Kinoshita, Kazuya, Sasaki, Takuma, Matsubara, Hisahiro

“…Background Esophageal squamous cell carcinoma (ESCC) is a malignant cancer with a poor prognosis. Chemoradiotherapy is one of the most important strategies for…”
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Antitumor effects of metformin are a result of inhibiting nuclear factor kappa B nuclear translocation in esophageal squamous cell carcinoma by Sekino, Nobufumi, Kano, Masayuki, Matsumoto, Yasunori, Sakata, Haruhito, Akutsu, Yasunori, Hanari, Naoyuki, Murakami, Kentaro, Toyozumi, Takeshi, Takahashi, Masahiko, Otsuka, Ryota, Yokoyama, Masaya, Shiraishi, Tadashi, Okada, Koichiro, Hoshino, Isamu, Iida, Keiko, Akimoto, Aki Komatsu, Matsubara, Hisahiro

“…Esophageal squamous cell carcinoma (ESCC) is an intractable digestive organ cancer that has proven difficult to treat despite multidisciplinary therapy, and a…”
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ZNF750 Expression Is a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma by Otsuka, Ryota, Akutsu, Yasunori, Sakata, Haruhito, Hanari, Naoyuki, Murakami, Kentaro, Kano, Masayuki, Toyozumi, Takeshi, Takahashi, Masahiko, Matsumoto, Yasunori, Sekino, Nobufumi, Yokoyama, Masaya, Okada, Koichiro, Shiraishi, Tadashi, Komatsu, Aki, Iida, Keiko, Matsubara, Hisahiro

“…ZNF750, a transcriptional regulator of epidermal differentiation, has been identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). The…”
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Metformin-Induced Heat Shock Protein Family A Member 6 Is a Promising Biomarker of Esophageal Squamous Cell Carcinoma by Sekino, Nobufumi, Kano, Masayuki, Kobayashi, Sohei, Murakami, Kentaro, Sakata, Haruhito, Toyozumi, Takeshi, Endo, Satoshi, Matsumoto, Yasunori, Suito, Hiroshi, Takahashi, Masahiko, Otsuka, Ryota, Yokoyama, Masaya, Shiraishi, Tadashi, Okada, Koichiro, Kamata, Toshiki, Ryuzaki, Takahiro, Hirasawa, Soichiro, Kinoshita, Kazuya, Sasaki, Takuma, Iida, Keiko, Komatsu, Aki, Matsubara, Hisahiro

“…Antidiabetic drug metformin exerts various antitumor effects on different cancers. Esophageal squamous cell carcinoma (ESCC) is an intractable digestive organ…”
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The concentration of programmed cell death-ligand 1 in the peripheral blood is a useful biomarker for esophageal squamous cell carcinoma by Akutsu, Yasunori, Murakami, Kentaro, Kano, Masayuki, Toyozumi, Takeshi, Matsumoto, Yasunori, Takahashi, Masahiko, Otsuka, Ryota, Sekino, Nobufumi, Yokoyama, Masaya, Shiraishi, Tadashi, Matsubara, Hisahiro

“…Background We determined the serum concentrations of Programmed cell death-1 (PD-1) and its ligands (PD-L1 and PD-L2) in patients with esophageal squamous cell…”
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ZNF750 Expression as a Novel Candidate Biomarker of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma by Otsuka, Ryota, Akutsu, Yasunori, Sakata, Haruhito, Hanari, Naoyuki, Murakami, Kentaro, Kano, Masayuki, Takahashi, Masahiko, Matsumoto, Yasunori, Sekino, Nobufumi, Yokoyama, Masaya, Iida, Keiko, Matsubara, Hisahiro

“…ZNF750, an epidermal differentiation regulator, has been suggested to act as a tumor suppressor of esophageal squamous cell carcinoma (ESCC). Although a…”
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Caspase recruitment domain family member 9 expression is a promising biomarker in esophageal squamous cell carcinoma by Sekino, Nobufumi, Kano, Masayuki, Sakata, Haruhito, Murakami, Kentaro, Toyozumi, Takeshi, Matsumoto, Yasunori, Ryuzaki, Takahiro, Ikeda, Junichiro, Ota, Masayuki, Matsubara, Hisahiro

“…Aim Esophageal squamous cell carcinoma (ESCC) is a refractory digestive organ cancer that requires better treatment strategies. We have recently reported that…”
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Mouse Epidermal Keratinocytes in Three-Dimensional Organotypic Coculture with Dermal Fibroblasts Form a Stratified Sheet Resembling Skin by IKUTA, Shuzo, SEKINO, Nobufumi, HARA, Takeshi, SAITO, Yuriko, CHIDA, Kazuhiro

“…We describe an organotypic model of mouse skin consisting of a stratified sheet of epidermal keratinocytes and dermal fibroblasts within a contracted collagen…”
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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy by Koikawa, Kazuhiro, Kibe, Shin, Suizu, Futoshi, Sekino, Nobufumi, Kim, Nami, Manz, Theresa D., Pinch, Benika J., Akshinthala, Dipikaa, Verma, Ana, Gaglia, Giorgio, Nezu, Yutaka, Ke, Shizhong, Qiu, Chenxi, Ohuchida, Kenoki, Oda, Yoshinao, Lee, Tae Ho, Wegiel, Babara, Clohessy, John G., London, Nir, Santagata, Sandro, Wulf, Gerburg M., Hidalgo, Manuel, Muthuswamy, Senthil K., Nakamura, Masafumi, Gray, Nathanael S., Zhou, Xiao Zhen, Lu, Kun Ping

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to current therapies attributed to inherent tumor heterogeneity and highly…”
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SIRT1 Expression Is a Promising Prognostic Biomarker in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis by Otsuka, Ryota, Sakata, Haruhito, Murakami, Kentaro, Kano, Masayuki, Endo, Satoshi, Toyozumi, Takeshi, Matsumoto, Yasunori, Suito, Hiroshi, Takahashi, Masahiko, Sekino, Nobufumi, Hirasawa, Soichiro, Kinoshita, Kazuya, Sasaki, Takuma, Matsubara, Hisahiro

“…Several articles have assessed the prognostic significance of the expression of sirtuin 1 (SIRT1) in esophageal squamous cell carcinoma (ESCC). However,…”
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HIF-1α stimulates the progression of oesophageal squamous cell carcinoma by activating the Wnt/β-catenin signalling pathway by Tang, Kang, Toyozumi, Takeshi, Murakami, Kentaro, Sakata, Haruhito, Kano, Masayuki, Endo, Satoshi, Matsumoto, Yasunori, Suito, Hiroshi, Takahashi, Masahiko, Sekino, Nobufumi, Otsuka, Ryota, Kinoshita, Kazuya, Hirasawa, Soichiro, Hu, Jie, Uesato, Masaya, Hayano, Koichi, Matsubara, Hisahiro

“…Background This study aimed to clarify the significance of the crosstalk between hypoxia-inducible factor-1α (HIF-1α) and the Wnt/β-catenin pathway in…”
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Current findings on the antitumor effects of metformin on esophageal squamous cell carcinoma by Sekino, Nobufumi, Kano, Masayuki, Murakami, Kentaro, Toyozumi, Takeshi, Hayano, Koichi, Ohira, Gaku, Matsubara, Hisahiro

“…Esophageal squamous cell carcinoma (ESCC) is an intractable type of cancer that requires novel therapeutic modalities, since the therapeutic outcomes are often…”
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The Antitumor Effects of Metformin on Gastric Cancer In Vitro and on Peritoneal Metastasis by Sekino, Nobufumi, Kano, Masayuki, Matsumoto, Yasunori, Sakata, Haruhito, Murakami, Kentaro, Toyozumi, Takeshi, Otsuka, Ryota, Yokoyama, Masaya, Shiraishi, Tadashi, Okada, Koichiro, Kamata, Toshiki, Ryuzaki, Takahiro, Matsubara, Hisahiro

“…Gastric cancer (GC) with peritoneal metastasis remains difficult to treat. The anti-diabetic drug metformin exerts various antitumor effects via the…”
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Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells by Hoshino, Isamu, Akutsu, Yasunori, Murakami, Kentaro, Akanuma, Naoki, Isozaki, Yuka, Maruyama, Tetsuro, Toyozumi, Takeshi, Matsumoto, Yasunori, Suito, Hiroshi, Takahashi, Masahiko, Sekino, Nobufumi, Komatsu, Aki, Suzuki, Takayoshi, Matsubara, Hisahiro

“…Background The expression of genes can be influenced by the balance of histone acetylation and/or histone demethylation, with an imbalance of these processes…”
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Abstract B07: Analysis of allele specific expression in esophageal squamous cell carcinoma with combination of exome sequencing and mRNA Sequencing by Takahashi, Masahiko, Nakaoka, Hirofumi, Akutsu, Yasunori, Hanari, Naoyuki, Murakami, Kentaro, Kano, Masayuki, Matsumoto, Yasunori, Otsuka, Ryota, Sekino, Nobufumi, Yokoyama, Masaya, Inoue, Itsuro, Matsubara, Hisahiro

“…Abstract In recent years, large-scale international studies have provide comprehensive catalogues of genomic alterations in cancers including Esophageal…”
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PS02.200: A COMPREHENSIVE SCREENING OF THE FRA-1 REGULATORY GENES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA by Toyozumi, Takeshi, Hoshino, Isamu, Sakata, Haruhito, Murakami, Kentaro, Kano, Masayuki, Takahashi, Masahiko, Sekino, Nobufumi, Yokoyama, Masaya, Okada, Koichiro, Shiraishi, Tadashi, Matsubara, Hisahiro

“…Abstract Background The expression of Fos-related antigen 1 (Fra-1) affects tumor progression, migration and invasion. We previously reported that a high Fra-1…”
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Genome-wide ChIP-seq data with a transcriptome analysis reveals the groups of genes regulated by histone demethylase LSD1 inhibition in esophageal squamous cell carcinoma cells by Hoshino, Isamu, Takahashi, Masahiko, Akutsu, Yasunori, Murakami, Kentaro, Matsumoto, Yasunori, Suito, Hiroshi, Sekino, Nobufumi, Komatsu, Aki, Iida, Keiko, Suzuki, Takayoshi, Inoue, Itsuro, Ishige, Fumitaka, Iwatate, Yosuke, Matsubara, Hisahiro

“…Expression of genes is controlled by histone modification, histone acetylation and methylation, but abnormalities of these modifications have been observed in…”
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