Search Results - "Sekiguchi, Tetsuya"

Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivatives by Kusumi, Kensuke, Shinozaki, Koji, Kanaji, Toshiya, Kurata, Haruto, Naganawa, Atsushi, Otsuki, Kazuhiro, Matsushita, Takeshi, Sekiguchi, Tetsuya, Kakuuchi, Akito, Seko, Takuya

“…[Display omitted] The structure–activity relationships of a novel series of sphingosine-1-phosphate receptor antagonists have been examined in detail. The…”
Get full text

Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives by Kusumi, Kensuke, Shinozaki, Koji, Yamaura, Yoshiyuki, Hashimoto, Ai, Kurata, Haruto, Naganawa, Atsushi, Otsuki, Kazuhiro, Matsushita, Takeshi, Sekiguchi, Tetsuya, Kakuuchi, Akito, Yamamoto, Hiroshi, Seko, Takuya

“…[Display omitted] The structure of the S1P2 antagonist 1 has been modified with the aim of improving its oral bioavailability. The chemical modification of the…”
Get full text

Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma by Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

“…An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is…”
Get full text

Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives by Kusumi, Kensuke, Shinozaki, Koji, Yamaura, Yoshiyuki, Hashimoto, Ai, Kurata, Haruto, Naganawa, Atsushi, Ueda, Hideyuki, Otsuki, Kazuhiro, Matsushita, Takeshi, Sekiguchi, Tetsuya, Kakuuchi, Akito, Seko, Takuya

“…[Display omitted] Our initial lead compound 2 was modified to improve its metabolic stability. The resulting compound 5 showed excellent metabolic stability in…”
Get full text

Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist by Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

“…The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297),…”
Get full text

Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis by Ishida, Akiharu, Okabe, Yasuyuki, Matsushita, Takeshi, Sekiguchi, Tetsuya, Nishio, Takuya, Komagata, Tatsuya, Iwaki, Masanori, Miyata, Hidenori, Katagi, Jun, Naganawa, Atsushi, Maruyama, Toru, Imagawa, Akira

“…[Display omitted] Somatostatin receptors are members of G-protein coupled receptor superfamily. Receptors can be classified into five subtypes, SSTR1 to 5. The…”
Get full text

Height and Angle Characteristics of Point Source Transmitting Power of Wireless Avionics Intra-Communication Systems Based on FDTD Analysis by Futatsumori, Shunichi, Morioka, Kazuyuki, Hikage, Takashi, Sekiguchi, Tetsuya, Yamamoto, Manabu, Nojima, Toshio

“…The equivalent isotopically radiated power (EIRP) of a wireless avionics intra-communication (WAIC) system is limited to 6 dBm/MHz at the geometrical center of…”
Get full text

Electromagnetic Field Strength Estimation on Hemisphere Around Aircraft Using FDTD Analysis at the Wireless Avionics Intra-Communication Band by Futatsumori, Shunichi, Morioka, Kazuyuki, Hikage, Takashi, Sekiguchi, Tetsuya, Yamamoto, Manabu, Nojima, Toshio

“…Wireless avionics intra-communication (WAIC) system will be operated at a frequency between 4,200-4,400 MHz, which is same frequency band as aircraft radio…”
Get full text

Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype‑2 (SSTR2) Agonists for the Treatment of Acromegaly by Ishida, Akiharu, Tajima, Yohei, Okabe, Yasuyuki, Matsushita, Takeshi, Sekiguchi, Tetsuya, Imaide, Satomi, Nomura, Yoshinori, Tanaka, Motoyuki, Nojima, Shoji, Yoshida, Atsushi, Iyoda, Yoko, Aoki, Shohei, Nishio, Takuya, Komagata, Tatsuya, Iwaki, Masanori, Shono, Tomoyuki, Naganawa, Atsushi, Imagawa, Akira

“…Acromegaly is a disease caused by the oversecretion of growth hormone. It is currently treated by intravenous injection with cyclic peptide drugs that activate…”
Get full text

Analysis of Radio Altimeter Interference due to Wireless Avionics Intra-Communication Systems by Using Large-Scale FDTD Method -Investigation on Airbus A320 Class Passenger Aircraft by Futatsumori, Shunichi, Morioka, Kazuyuki, Kohmura, Akiko, Yonemoto, Naruto, Hikage, Takashi, Sekiguchi, Tetsuya, Yamamoto, Manabu, Nojima, Toshio

“…Radio altimeters and wireless avionics intracommunication (WAIC) systems are both operated at the frequency band 4,200 MHz–4,400 MHz. Hence, a detailed…”
Get full text

Discovery of novel S1P sub(2) antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives by Kusumi, Kensuke, Shinozaki, Koji, Yamaura, Yoshiyuki, Hashimoto, Ai, Kurata, Haruto, Naganawa, Atsushi, Otsuki, Kazuhiro, Matsushita, Takeshi, Sekiguchi, Tetsuya, Kakuuchi, Akito, Yamamoto, Hiroshi, Seko, Takuya

“…The structure of the S1P sub(2) antagonist 1 has been modified with the aim of improving its oral bioavailability. The chemical modification of the alkyl chain…”
Get full text

Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid by Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Aratani, Yoshiyuki, Egashira, Hiromu, Matsumura, Naoya, Inoue, Atsuto, Yonetomi, Yasuo, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

“…[Display omitted] A potent, orally available dual CysLT1 and CysLT2 receptor antagonist with a dicarboxylic acid is described…”
Get full text

Discovery of Gemilukast (ONO-6950), a Dual CysLT 1 and CysLT 2 Antagonist As a Therapeutic Agent for Asthma by Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

Get full text

Discovery of Highly Potent Dual CysLT 1 and CysLT 2 Antagonist by Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

Get full text

Interference Path Loss Measurements of Beechcraft B300 Aircraft at 4 GHz Wireless Avionics Intra-Communication Band by Futatsumori, Shunichi, Miyazaki, Nxorihiko, Hikage, Takashi, Sekiguchi, Tetsuya, Yamamoto, Manabu, Nojima, Toshio

“…Wireless Avionics Intra-Communication (WAIC) devices operate between 4,200 MHz and 4,400 MHz. This is the same frequency band as aircraft radio altimeters. In…”
Get full text

Height and Angle Characteristics of Point Source Transmitting Power of Wireless Avionics Intra-Communication Systems Based on FDTD Analysis by Futatsumori, Shunichi, Morioka, Kazuyuki, Hikage, Takashi, Sekiguchi, Tetsuya, Yamamoto, Manabu, Nojima, Toshio

“…The equivalent isotopically radiated power (EIRP) of a wireless avionics intra-communication (WAIC) system is limited to 6 dBm/MHz at the geometrical center of…”
Get full text

Point Source Transmitting Power Estimation of Wireless Avionics Intra-Communication Systems Using the Large-Scale FDTD Method by Futatsumori, Shunichi, Morioka, Kazuyuki, Hikage, Takashi, Sekiguchi, Tetsuya, Yamamoto, Manabu, Nojima, Toshio

“…Wireless avionics intra-communication (WAIC) systems are operated at the same frequency bands as aircraft radio altimeters, i.e., 4,200-4,400 MHz. The…”
Get full text

Analysis of radar altimeter interference due to wireless avionics intra-communication systems by using large-scale FDTD method - Investigation on Airbus A320 class passenger aircraft by Futatsumori, Shunichi, Morioka, Kazuyuki, Kohmura, Akiko, Yonemoto, Naruto, Hikage, Takashi, Sekiguchi, Tetsuya, Yamamoto, Manabu, Nojima, Toshio

“…Radio altimeters and wireless avionics intra-communication (WAIC) systems are both operated at the frequency band 4,200 MHz-4,400 MHz. Hence, a detailed…”
Get full text