Search Results - "Sekiguchi, Mutsuo"

Two ways of escaping from oxidative RNA damage: Selective degradation and cell death by Ishii, Takashi, Sekiguchi, Mutsuo

“…Reactive oxygen species (ROS) are produced during normal cellular metabolism, and various oxidized compounds are formed by the ROS attack. Among oxidized…”
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Specific binding of PCBP1 to heavily oxidized RNA to induce cell death by Ishii, Takashi, Hayakawa, Hiroshi, Igawa, Tatsuhiro, Sekiguchi, Takeshi, Sekiguchi, Mutsuo

“…In aerobically growing cells, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG), which induces alteration in their gene expression. We…”
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PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions by Ishii, Takashi, Igawa, Tatsuhiro, Hayakawa, Hiroshi, Fujita, Tsugumi, Sekiguchi, Mutsuo, Nakabeppu, Yusaku

“…PCBP1, a member of the poly(C)-binding protein (PCBP) family, has the capability of binding heavily oxidized RNA and therefore participates in the cellular…”
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Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis by Fujikane, Ryosuke, Komori, Kayoko, Sekiguchi, Mutsuo, Hidaka, Masumi

“…O 6 -Methylguanine produced in DNA can pair with thymine during DNA replication, thus leading to a G-to-A transition mutation. To prevent such outcomes, cells…”
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Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells by Ishii, Takashi, Hayakawa, Hiroshi, Sekiguchi, Takeshi, Adachi, Noritaka, Sekiguchi, Mutsuo

“…In aerobically growing cells, in which reactive oxygen species are produced, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine, which induces…”
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Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells by Dai, Da-Peng, Gan, Wei, Hayakawa, Hiroshi, Zhu, Jia-Lou, Zhang, Xiu-Qing, Hu, Guo-Xin, Xu, Tao, Jiang, Zhe-Li, Zhang, Li-Qun, Hu, Xue-Da, Nie, Ben, Zhou, Yue, Li, Jin, Zhou, Xiao-Yang, Li, Jian, Zhang, Tie-Mei, He, Qing, Liu, Dong-Ge, Chen, Hai-Bo, Yang, Nan, Zuo, Ping-Ping, Zhang, Zhi-Xin, Yang, Huan-Ming, Wang, Yao, Wilson, Samuel H., Zeng, Yi-Xin, Wang, Jian-Ye, Sekiguchi, Mutsuo, Cai, Jian-Ping

“…Reactive oxygen species formed within the mammalian cell can produce 8-oxo-7,8-dihydroguanine (8-oxoG) in mRNA, which can cause base mispairing during gene…”
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Elimination and Utilization of Oxidized Guanine Nucleotides in the Synthesis of RNA and Its Precursors by Sekiguchi, Takeshi, Ito, Riyoko, Hayakawa, Hiroshi, Sekiguchi, Mutsuo

“…Reactive oxygen species are produced as side products of oxygen utilization and can lead to the oxidation of nucleic acids and their precursor nucleotides…”
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Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression by Oka, Sugako, Tsuzuki, Teruhisa, Hidaka, Masumi, Ohno, Mizuki, Nakatsu, Yoshimichi, Sekiguchi, Mutsuo

“…Oxidative stress plays a pivotal role in the differentiation and proliferation of cells and programmed cell death. However, studies on the role of oxidative…”
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Oxidative nucleotide damage: consequences and prevention by Sekiguchi, Mutsuo, Tsuzuki, Teruhisa

“…8-Oxoguanine (8-oxo-7,8-dihydroguanine) is produced in DNA, as well as in nucleotide pools of cells, by reactive oxygen species normally formed during cellular…”
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The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress by Hashiguchi, Kazunari, Hayashi, Michio, Sekiguchi, Mutsuo, Umezu, Keiko

“…The hydrolysis of nucleotides containing 8-oxo-7,8-dihydroguanine (8-oxoG) is important in the maintenance of genome stability. Human cells possess three types…”
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Search for Proteins Required for Accurate Gene Expression under Oxidative Stress by Inokuchi, Hachiro, Ito, Riyoko, Sekiguchi, Takeshi, Sekiguchi, Mutsuo

“…In aerobically growing cells, in which reactive oxygen species are produced, the guanine base is oxidized to 8-oxo-7,8-dihydroguanine, which can pair with…”
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Age-Dependent Accumulation of 8-Oxoguanine in the DNA and RNA in Various Rat Tissues by Cai, Jian-Ping, Hayakawa, Hiroshi, Chen, Lian-Guo, Sekiguchi, Mutsuo, Hu, Guo-Xin, Shi, Fei, Nie, Ben, Gan, Wei

“…The relationship between the oxidative damage of nucleic acids and aging of animals was investigated by analyzing the nucleic acids derived from various tissue…”
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Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase ( ) gene expression in human cancer by Nakagawachi, Tetsuji, Soejima, Hidenobu, Urano, Takeshi, Zhao, Wei, Higashimoto, Ken, Satoh, Yuji, Matsukura, Shiroh, Kudo, Shinichi, Kitajima, Yoshihiko, Harada, Haruhito, Furukawa, Koichi, Matsuzaki, Hideki, Emi, Mitsuru, Nakabeppu, Yusaku, Miyazaki, Kohji, Sekiguchi, Mutsuo, Mukai, Tsunehiro

“…O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents…”
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Multiple Enzyme Activities of Escherichia coli MutT Protein for Sanitization of DNA and RNA Precursor Pools by Ito, Riyoko, Hayakawa, Hiroshi, Sekiguchi, Mutsuo, Ishibashi, Toru

“…8-OxoGua (8-oxo-7,8-dihydroguanine) is produced in nucleic acids as well as in nucleotide pools of cells, by reactive oxygen species normally formed during…”
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Diverse substrate recognition and hydrolysis mechanisms of human NUDT5 by Arimori, Takao, Tamaoki, Haruhiko, Nakamura, Teruya, Kamiya, Hiroyuki, Ikemizu, Shinji, Takagi, Yasumitsu, Ishibashi, Toru, Harashima, Hideyoshi, Sekiguchi, Mutsuo, Yamagata, Yuriko

“…Human NUDT5 (hNUDT5) hydrolyzes various modified nucleoside diphosphates including 8-oxo-dGDP, 8-oxo-dADP and ADP-ribose (ADPR). However, the structural basis…”
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Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein by Ito, Riyoko, Sekiguchi, Mutsuo, Setoyama, Daiki, Nakatsu, Yoshimichi, Yamagata, Yuriko, Hayakawa, Hiroshi

“…MutT-related proteins, including Escherichia coli MutT and the human MTH1 (NUDT1), degrade 8-oxo-7, 8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP) to…”
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A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides by Ishibashi, Toru, Hayakawa, Hiroshi, Sekiguchi, Mutsuo

“…MutT‐related proteins, including the Escherichia coli MutT and human MutT homologue 1 (MTH1) proteins, degrade 8‐oxo‐ 7,8‐dihydrodeoxyguanosine triphosphate…”
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Structural and Dynamic Features of the MutT Protein in the Recognition of Nucleotides with the Mutagenic 8-Oxoguanine Base by Nakamura, Teruya, Meshitsuka, Sachiko, Kitagawa, Seiju, Abe, Nanase, Yamada, Junichi, Ishino, Tetsuya, Nakano, Hiroaki, Tsuzuki, Teruhisa, Doi, Takefumi, Kobayashi, Yuji, Fujii, Satoshi, Sekiguchi, Mutsuo, Yamagata, Yuriko

“…Escherichia coli MutT hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, an event that can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA. Of the…”
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The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine by Fujikane, Ryosuke, Sanada, Masayuki, Sekiguchi, Mutsuo, Hidaka, Masumi

“…O⁶-Methylguanine, one of alkylated DNA bases, is especially mutagenic. Cells containing this lesion are eliminated by induction of apoptosis, associated with…”
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Spontaneous Tumorigenesis in Mice Defective in the MTH1 Gene Encoding 8-Oxo-dGTPase by Tsuzuki, Teruhisa, Egashira, Akinori, Igarashi, Hisato, Iwakuma, Tomoo, Nakatsuru, Yoko, Tominaga, Yohei, Kawate, Hisaya, Nakao, Kazuki, Nakamura, Kenji, Ide, Fumio, Kura, Shinobu, Nakabeppu, Yusaku, Katsuki, Motoya, Ishikawa, Takatoshi, Sekiguchi, Mutsuo

“…Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among…”
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