Search Results - "Sekiguchi, Kensuke"

Endothelial Dysfunction in Diabetes by Takeda, Yusuke, Matoba, Keiichiro, Sekiguchi, Kensuke, Nagai, Yosuke, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Diabetes is a worldwide health issue closely associated with cardiovascular events. Given the pandemic of obesity, the identification of the basic…”
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The Physiology, Pathology, and Therapeutic Interventions for ROCK Isoforms in Diabetic Kidney Disease by Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Sekiguchi, Kensuke, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase that was originally identified as RhoA interacting protein. A diverse…”
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Renal ROCK Activation and Its Pharmacological Inhibition in Patients With Diabetes by Matoba, Keiichiro, Sekiguchi, Kensuke, Nagai, Yosuke, Takeda, Yusuke, Takahashi, Hiroshi, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase with essential roles in cytoskeletal functions. Substantial evidence…”
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ROCK2-induced metabolic rewiring in diabetic podocytopathy by Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Sekiguchi, Kensuke, Ukichi, Rikako, Takahashi, Hiroshi, Aizawa, Daisuke, Ikegami, Masahiro, Tachibana, Toshiaki, Kawanami, Daiji, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Loss of podocytes is a common feature of diabetic renal injury and a key contributor to the development of albuminuria. We found that podocyte Rho associated…”
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Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis by Matoba, Keiichiro, Nagai, Yosuke, Sekiguchi, Kensuke, Ohashi, Shinji, Mitsuyoshi, Etsuko, Shimoda, Masayuki, Tachibana, Toshiaki, Kawanami, Daiji, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Focal segmental glomerulosclerosis (FSGS) shares podocyte damage as an essential pathological finding. Several mechanisms underlying podocyte injury have been…”
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111-OR: Vascular Endothelium-Specific ROCK2 Deficiency Inhibits the Progression of Obesity via Adipocyte Browning by Ohashi, Shinji, Matoba, Keiichiro, Sekiguchi, Kensuke, Mitsuyoshi, Etsuko, Nagai, Yosuke, Nishimura, Rimei

“…Introduction and Objective: The vascular endothelium has evolved anatomical and functional network between adipocytes in adipose tissue, secreting several…”
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391-P: Targeted Deletion of Rho-Associated Coiled-Coil–Containing Protein Kinase 2 in Kidney Tubules Suppresses Expression and Function of Mineralocorticoid Receptor in Mice by Sekiguchi, Kensuke, Matoba, Keiichiro, Ohashi, Shinji, Mitsuyoshi, Etsuko, Nagai, Yosuke, Nishimura, Rimei

“…The mineralocorticoid receptor (MR) is a steroid receptor responsible for fluid and electrolyte reabsorption in kidney tubules. Traditionally, MR has been…”
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405-P: ROCK2 Activation and Its Role in Folic Acid–Induced Murine Model of Nephropathy by SEKIGUCHI, KENSUKE, MATOBA, KEIICHIRO, OHASHI, SHINJI, MITSUYOSHI, ETSUKO, NAGAI, YOSUKE, TAKEDA, YUSUKE, NISHIMURA, RIMEI

“…Over 2 million people currently receive treatment with dialysis or a kidney transplant throughout the world. Thus, developing a new strategy to treat chronic…”
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386-P: ROCK1 Regulation of AMPK in the Development of Diabetic Nephropathy by NAGAI, YOSUKE, MATOBA, KEIICHIRO, SEKIGUCHI, KENSUKE, TAKEDA, YUSUKE, KANAZAWA, YASUSHI, KAWANAMI, DAIJI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…Rho-associated, coiled-coil-containing protein kinase (ROCK) is activated in the diabetic kidney. Studies over the past decade have illuminated ROCK signaling…”
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6-OR: Vascular Endothelial ROCK2 Deficiency Promotes Browning and Burning of White Adipose Tissue by TAKEDA, YUSUKE, MATOBA, KEIICHIRO, UKICHI, RIKAKO, SEKIGUCHI, KENSUKE, NAGAI, YOSUKE, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The accumulation of visceral fat is associated with multiple coronary risk factors such as glucose intolerance, dyslipidemia, and hypertension. We have…”
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388-P: Renal ROCK2 Activity in Folic Acid-Induced Nephropathy by SEKIGUCHI, KENSUKE, MATOBA, KEIICHIRO, UKICHI, RIKAKO, NAGAI, YOSUKE, TAKEDA, YUSUKE, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The small GTPase Rho and its effector Rho-kinase (ROCK) are involved in the pathogenesis of diabetic nephropathy. In chronic kidney diseases including diabetic…”
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Rho-associated, coiled-coil-containing protein kinase 2 regulates expression of mineralocorticoid receptor to mediate sodium reabsorption in mice by Sekiguchi, Kensuke, Matoba, Keiichiro, Nagai, Yosuke, Nagao, Satoru, Ohashi, Shinji, Mitsuyoshi, Etsuko, Hayashi, Takeshi, Kawanami, Daiji, Yokota, Tamotsu, Shibata, Hirotaka, Utsunomiya, Kazunori, Nishimura, Rimei

“…The mineralocorticoid receptor (MR) is a member of the nuclear receptor family that was initially identified to regulate blood pressure through its ability to…”
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Proton Conduction at High Temperature in High-Symmetry Hydrogen-Bonded Molecular Crystals of Ru III Complexes with Six Imidazole-Imidazolate Ligands by Tadokoro, Makoto, Itoh, Masaki, Nishimura, Ryota, Sekiguchi, Kensuke, Hoshino, Norihisa, Kamebuchi, Hajime, Miyazaki, Jun, Kobayashi, Fumiya, Mizuno, Motohiro, Akutagawa, Tomoyuki

“…A new H-bonded crystal [Ru (Him) (Im) ] with three imidazole (Him) and three imidazolate (Im ) groups was prepared to obtain a higher-temperature proton…”
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Proton Conduction at High Temperature in High‐Symmetry Hydrogen‐Bonded Molecular Crystals of RuIII Complexes with Six Imidazole–Imidazolate Ligands by Tadokoro, Makoto, Itoh, Masaki, Nishimura, Ryota, Sekiguchi, Kensuke, Hoshino, Norihisa, Kamebuchi, Hajime, Miyazaki, Jun, Kobayashi, Fumiya, Mizuno, Motohiro, Akutagawa, Tomoyuki

“…Invited for the cover of this issue is mainly the group of Makoto Tadokoro and co‐workers at Tokyo University of Science. Other co‐workers are Masaki Itoh,…”
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Front Cover: Proton Conduction at High Temperature in High‐Symmetry Hydrogen‐Bonded Molecular Crystals of Ru III Complexes with Six Imidazole‐Imidazolate Ligands (Chem. Eur. J. 47/2022) by Tadokoro, Makoto, Itoh, Masaki, Nishimura, Ryota, Sekiguchi, Kensuke, Hoshino, Norihisa, Kamebuchi, Hajime, Miyazaki, Jun, Kobayashi, Fumiya, Mizuno, Motohiro, Akutagawa, Tomoyuki

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Proton Conduction at High Temperature in High‐Symmetry Hydrogen‐Bonded Molecular Crystals of RuIII Complexes with Six Imidazole‐Imidazolate Ligands by Tadokoro, Makoto, Itoh, Masaki, Nishimura, Ryota, Sekiguchi, Kensuke, Hoshino, Norihisa, Kamebuchi, Hajime, Miyazaki, Jun, Kobayashi, Fumiya, Mizuno, Motohiro, Akutagawa, Tomoyuki

“…A new H‐bonded crystal [RuIII(Him)3(Im)3] with three imidazole (Him) and three imidazolate (Im−) groups was prepared to obtain a higher‐temperature proton…”
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Proton Conduction at High Temperature in High‐Symmetry Hydrogen‐Bonded Molecular Crystals of Ru III Complexes with Six Imidazole–Imidazolate Ligands by Tadokoro, Makoto, Itoh, Masaki, Nishimura, Ryota, Sekiguchi, Kensuke, Hoshino, Norihisa, Kamebuchi, Hajime, Miyazaki, Jun, Kobayashi, Fumiya, Mizuno, Motohiro, Akutagawa, Tomoyuki

“…Abstract Invited for the cover of this issue is mainly the group of Makoto Tadokoro and co‐workers at Tokyo University of Science. Other co‐workers are Masaki…”
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Front Cover: Proton Conduction at High Temperature in High‐Symmetry Hydrogen‐Bonded Molecular Crystals of RuIII Complexes with Six Imidazole‐Imidazolate Ligands (Chem. Eur. J. 47/2022) by Tadokoro, Makoto, Itoh, Masaki, Nishimura, Ryota, Sekiguchi, Kensuke, Hoshino, Norihisa, Kamebuchi, Hajime, Miyazaki, Jun, Kobayashi, Fumiya, Mizuno, Motohiro, Akutagawa, Tomoyuki

“…The crystals of [RuIII(HIm)3(Im)3](1) are one of the rapid proton‐transport materials to work as proton conductors at high temperatures. The proton flow is…”
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394-P: ROCK1/AMPK Axis Regulates the Development of Diabetic Kidney Disease via Modulation of Fatty Acid Metabolism by NAGAI, YOSUKE, MATOBA, KEIICHIRO, SEKIGUCHI, KENSUKE, UKICHI, RIKAKO, TAKEDA, YUSUKE, AKAMINE, TOMOYO, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The small GTPase Rho and its effector Rho-kinase (ROCK) are involved in the pathogenesis of diabetic kidney disease. Accumulating evidence shows that renal…”
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117-OR: Inhibition of Endothelial ROCK2 Induces Fat Browning and Improves Metabolic Dysfunction by TAKEDA, YUSUKE, MATOBA, KEIICHIRO, NAGAI, YOSUKE, UKICHI, RIKAKO, SEKIGUCHI, KENSUKE, AKAMINE, TOMOYO, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…Intraperitoneal fat is regarded as an important risk factor for dyslipidemia, impaired glucose tolerance, and coronary heart diseases. However, the detailed…”
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