Anxiolytic activity evaluation of four medicinal plants from Cameroon

Afrormosia laxiflora (A. laxiflora), Chenopodium ambrosioides (C. ambrosioides), Microglossa pyrifolia (M. pyrifolia) and Mimosa pudica (M. pudica) are plants used in traditional medicine in Cameroon to treat insomnia, epilepsy, anxiety, and agitation. They were evaluated for their anxiolytic like a...

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Bibliographic Details
Published in:	African journal of traditional, complementary, and alternative medicines Vol. 8; no. 5 Suppl; pp. 130 - 139
Main Authors:	Bum, E Ngo, Soudi, S, Ayissi, E R, Dong, C, Lakoulo, N H, Maidawa, F, Seke, P F E, Nanga, L D, Taiwe, G S, Dimo, T, Njikam, Njifutie, Rakotonirina, A, Rakotonirina, S V, Kamanyi, A
Format:	Journal Article
Language:	English
Published:	Nigeria African Networks on Ethnomedicines 01-01-2011
Subjects:	Analysis of Variance Animals Anti-Anxiety Agents - isolation & purification Anti-Anxiety Agents - pharmacology Anxiety - drug therapy Behavior, Animal - drug effects Body Temperature - drug effects Cameroon Chenopodium ambrosioides - chemistry Dose-Response Relationship, Drug Fever - drug therapy Male Maze Learning - drug effects Medicine, Traditional Mice Mimosa - chemistry Motor Activity - drug effects Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal - chemistry Psychological Tests Review Stress, Physiological Cameroon Medicinal plants Agitation Anxiety Traditional medicine
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Summary:	Afrormosia laxiflora (A. laxiflora), Chenopodium ambrosioides (C. ambrosioides), Microglossa pyrifolia (M. pyrifolia) and Mimosa pudica (M. pudica) are plants used in traditional medicine in Cameroon to treat insomnia, epilepsy, anxiety, and agitation. They were evaluated for their anxiolytic like activity in mice. Animal models (elevated plus maze and stress-induced hyperthermia tests) were used. The four plants showed anxiolytic activity. In stress-induced hyperthermia test, A. laxiflora, C. ambrosioides, M. pyrifolia and M. pudica significantly antagonised the increase of temperature. ΔT° decreased from 0.75°C in the control group to 0.36°C at the dose of 110 mg/kg for A. laxiflora; from 1°C in the control group to -1.1°C at the dose of 120 mg/kg for C. ambrosioides; from 1.7°C in the control group to 0.2°C at the dose of 128 mg/kg for M. pyrifolia and from 1.3°C in the control group to 0.5°C at the dose of 180 mg/kg for M. pudica. In the elevated plus maze test, the four plants increased the number of entries into, percentage of entries into, and percentage of time in open arms. A. laxiflora, C. ambrosioides and M. pudica also reduced the percentage of entries and time in closed arms. In addition, C. ambrosioides, M. pyrifolia and M. pudica showed antipyretic activity by reducing the body temperature. The results suggested that C. ambrosioides, M. pyrifolia and M. pudica posses anxiolytic-like and antipyretic activities while A. laxiflora possesses only anxiolytic-like properties. These plants could be helpful in the treatment of anxiety and fever in traditional medicine in Cameroon.
ISSN:	0189-6016 2505-0044 0189-6016
DOI:	10.4314/ajtcam.v8i5S.19